GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | affects expression | EXP | | 6480464 | CTD | lead acetate affects the expression of MAPK3 | PMID:24293362 | Mapk3 | decreases phosphorylation | EXP | | 6480464 | CTD | lead acetate results in decreased phosphorylation of MAPK3 protein | PMID:25981801 | Mapk3 | increases phosphorylation | EXP | | 6480464 | CTD | lead acetate results in increased phosphorylation of MAPK3 protein | PMID:22728154 PMID:26797587 PMID:26926986 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK3 protein; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK3 protein; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein] | PMID:11233754 PMID:17298174 PMID:20829427 PMID:22728154 PMID:26797587 PMID:34350654 PMID:35307918 | Mapk3 | increases oxidation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | lead acetate results in increased oxidation of MAPK3 protein; lead acetate results in increased oxidation of MAPK3 protein modified form | PMID:23370007 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | lead acetate results in increased phosphorylation of MAPK3 protein | PMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435 PMID:26542248 | Mapk3 | increases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | lead acetate results in increased phosphorylation of MAPK3 protein | PMID:23855546 PMID:24530660 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; [E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]] which results in decreased phosphorylation of MAPK3 protein modified form; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; E 3330 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] | PMID:11861786 PMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435 | Mapk3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein] | PMID:23855546 | |
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