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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects expressionEXP 6480464CTDlead acetate affects the expression of MAPK3PMID:24293362
Mapk3decreases phosphorylationEXP 6480464CTDlead acetate results in decreased phosphorylation of MAPK3 proteinPMID:25981801
Mapk3increases phosphorylationEXP 6480464CTDlead acetate results in increased phosphorylation of MAPK3 proteinPMID:22728154 PMID:26797587 PMID:26926986
Mapk3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK3 protein; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK3 protein; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]PMID:11233754 PMID:17298174 PMID:20829427 PMID:22728154 PMID:26797587 PMID:34350654 PMID:35307918
Mapk3increases oxidationISOMAPK3 (Homo sapiens)6480464CTDlead acetate results in increased oxidation of MAPK3 protein; lead acetate results in increased oxidation of MAPK3 protein modified formPMID:23370007
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDlead acetate results in increased phosphorylation of MAPK3 proteinPMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435 PMID:26542248
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDlead acetate results in increased phosphorylation of MAPK3 proteinPMID:23855546 PMID:24530660
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; [E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]] which results in decreased phosphorylation of MAPK3 protein modified form; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; E 3330 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:11861786 PMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDQuercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]PMID:23855546
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