GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein; Arsenic results in increased phosphorylation of and results in increased activity of MAPK3 protein; O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK3 protein]; O(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK3 protein] | PMID:11756236 PMID:15210857 PMID:35307918 | Mapk3 | affects methylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Arsenic affects the methylation of MAPK3 gene | PMID:25304211 | Mapk3 | decreases activity | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Arsenic results in decreased activity of MAPK3 protein | PMID:21784148 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Arsenic analog results in increased phosphorylation of MAPK3 protein; Arsenic results in increased phosphorylation of MAPK3 protein | PMID:24582688 PMID:25273566 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | [Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Iron co-treated with Arsenic] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK3 protein]; Arsenic results in increased phosphorylation of and results in increased activity of MAPK3 protein; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; CAT protein inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; KRAS affects the reaction [Arsenic results in increased phosphorylation of MAPK3 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]]; reparixin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]; SOCS3 protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]] | PMID:14633691 PMID:21687637 PMID:23100159 PMID:24582688 PMID:25273566 PMID:32062438 PMID:32645460 PMID:33396024 PMID:33921748 PMID:36504884 | Mapk3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein | PMID:30889423 PMID:32062438 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |