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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:29474
Term: (S)-3,5-dihydroxyphenylglycine
Definition: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
Chemical ID: MESH:C079215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTD3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 proteinPMID:35137321
Mapk3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Chlordan inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; Chlordan inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]; Chlorpyrifos inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]PMID:16600209 PMID:35137321
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTD3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 proteinPMID:16600209
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]PMID:30205134
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]PMID:16600209
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