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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTD[Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein] which results in increased phosphorylation of ELK1 protein; Asbestos, Crocidolite results in increased phosphorylation of MAPK3 proteinPMID:12495932 PMID:14627993
Mapk3multiple interactionsEXP 6480464CTDarginyl-glycyl-aspartic acid inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; ITGB1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]PMID:14627993
Mapk3affects localizationISOMapk3 (Mus musculus)6480464CTDAsbestos, Crocidolite affects the localization of MAPK3 protein modified formPMID:12598305
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in decreased phosphorylation of MAPK3 proteinPMID:17191120 PMID:18314537
Mapk3increases expressionISOMapk3 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased expression of MAPK3 proteinPMID:12598305
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased phosphorylation of MAPK3 proteinPMID:16908449 PMID:16966607 PMID:21454801 PMID:21762757 PMID:22573546
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased phosphorylation of MAPK3 proteinPMID:11306433 PMID:12598305 PMID:14737115 PMID:18192500 PMID:24130165
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; EGFR protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; SOD1 protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]PMID:16908449 PMID:16966607 PMID:21454801 PMID:21762757 PMID:22573546
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; Antigens, Polyomavirus Transforming promotes the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; Asbestos, Crocidolite results in increased phosphorylation of and affects the localization of MAPK3 protein; MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; SRC protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]PMID:14737115 PMID:15374964 PMID:18192500 PMID:24130165
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