GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | decreases expression | EXP | | 6480464 | CTD | arsenite results in decreased expression of MAPK3 protein | PMID:29324385 | Mapk3 | increases phosphorylation | EXP | | 6480464 | CTD | arsenite results in increased phosphorylation of MAPK3 protein | PMID:17038550 PMID:20377179 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; Selenium inhibits the reaction [arsenite results in decreased expression of MAPK3 protein] | PMID:20377179 PMID:21344382 PMID:29324385 | Mapk3 | decreases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | arsenite results in decreased phosphorylation of MAPK3 protein | PMID:25145660 | Mapk3 | increases activity | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | arsenite results in increased activity of MAPK3 protein | PMID:14674888 | Mapk3 | increases activity | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | arsenite results in increased activity of MAPK3 protein | PMID:19059425 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | arsenite results in increased phosphorylation of MAPK3 protein | PMID:12640124 PMID:15037631 PMID:22387281 PMID:23469214 PMID:31934280 | Mapk3 | increases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | arsenite results in increased phosphorylation of MAPK3 protein | PMID:19808956 PMID:22387281 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; [sodium arsenite results in increased abundance of arsenite] promotes the reaction [HBEGF protein results in increased phosphorylation of MAPK3 protein]; [sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; CAV1 protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; EGFR protein affects the reaction [arsenite results in increased activity of MAPK3 protein]; RELA mutant form inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein] | PMID:12640124 PMID:14674888 PMID:16008523 PMID:22387281 PMID:31616959 PMID:31934280 PMID:32076005 | Mapk3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK3 protein] | PMID:14516795 PMID:19808956 PMID:22387281 PMID:23639288 | |
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