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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases expressionEXP 6480464CTDarsenite results in decreased expression of MAPK3 proteinPMID:29324385
Mapk3increases phosphorylationEXP 6480464CTDarsenite results in increased phosphorylation of MAPK3 proteinPMID:17038550 PMID:20377179
Mapk3multiple interactionsEXP 6480464CTDarsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; Selenium inhibits the reaction [arsenite results in decreased expression of MAPK3 protein]PMID:20377179 PMID:21344382 PMID:29324385
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDarsenite results in decreased phosphorylation of MAPK3 proteinPMID:25145660
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDarsenite results in increased activity of MAPK3 proteinPMID:14674888
Mapk3increases activityISOMapk3 (Mus musculus)6480464CTDarsenite results in increased activity of MAPK3 proteinPMID:19059425
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDarsenite results in increased phosphorylation of MAPK3 proteinPMID:12640124 PMID:15037631 PMID:22387281 PMID:23469214 PMID:31934280
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDarsenite results in increased phosphorylation of MAPK3 proteinPMID:19808956 PMID:22387281
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; [sodium arsenite results in increased abundance of arsenite] promotes the reaction [HBEGF protein results in increased phosphorylation of MAPK3 protein]; [sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; CAV1 protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; EGFR protein affects the reaction [arsenite results in increased activity of MAPK3 protein]; RELA mutant form inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]PMID:12640124 PMID:14674888 PMID:16008523 PMID:22387281 PMID:31616959 PMID:31934280 PMID:32076005
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; MAP3K8 protein affects the reaction [arsenite results in increased phosphorylation of MAPK3 protein]PMID:14516795 PMID:19808956 PMID:22387281 PMID:23639288
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