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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:90724
Term: AM-251
Definition: A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Chemical ID: MESH:C103505
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDAM 251 results in increased phosphorylation of MAPK3 proteinPMID:17596442
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDAM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]PMID:17583570 PMID:18159069 PMID:19477951 PMID:29285308
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDAM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]PMID:27071101 PMID:27461790 PMID:27543109
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