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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:4469
Term: (S)-amphetamine
Definition: A 1-phenylpropan-2-amine that has S configuration.
Chemical ID: MESH:D003913
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDDextroamphetamine results in increased phosphorylation of MAPK3 proteinPMID:12377393 PMID:16459022
Mapk3multiple interactionsEXP 6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK3 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK3 protein]PMID:12377393 PMID:16459022
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDDextroamphetamine results in increased phosphorylation of MAPK3 proteinPMID:17596442
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDCNR1 mutant form inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK3 protein]PMID:17596442
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