GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK3 protein]; [[Copper binds to neocuproine] which results in increased activity of MAPK3 protein] which results in increased phosphorylation of MBP protein; [Copper binds to neocuproine] which results in increased activity of MAPK3 protein; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein; [pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein] | PMID:10941151 PMID:18056745 PMID:22085843 PMID:22276220 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Copper results in increased phosphorylation of MAPK3 protein | PMID:15880691 PMID:16079071 | Mapk3 | increases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Copper analog results in increased phosphorylation of MAPK3 protein | PMID:21319953 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Chelating Agents binds to Copper] which results in decreased expression of MAPK3 mRNA; [Chelating Agents binds to Copper] which results in decreased phosphorylation of MAPK3 protein; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK3 protein; [Thiosemicarbazones binds to Copper] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; TP53 protein inhibits the reaction [Copper results in increased phosphorylation of MAPK3 protein] | PMID:15880691 PMID:16648635 PMID:18346929 PMID:20931265 PMID:23033007 PMID:30911355 | | ||||||||||||||||||||||
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