GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | decreases phosphorylation | EXP | | 6480464 | CTD | Manganese results in decreased phosphorylation of MAPK3 protein | PMID:25981801 | Mapk3 | increases phosphorylation | EXP | | 6480464 | CTD | Manganese results in increased phosphorylation of MAPK3 protein | PMID:11933051 PMID:16488514 PMID:16787641 PMID:22427945 PMID:24787138 PMID:24845367 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; Deferoxamine promotes the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein] | PMID:11933051 PMID:16488514 PMID:16787641 PMID:22427945 PMID:32574669 | Mapk3 | decreases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Manganese results in decreased phosphorylation of MAPK3 protein | PMID:17043766 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Manganese results in increased phosphorylation of MAPK3 protein | PMID:17045426 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein] | PMID:17055454 PMID:31676349 | Mapk3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein] | PMID:31676349 PMID:31690173 | | ||||||||||||||||||||||
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