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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases expressionEXP 6480464CTDCisplatin results in decreased expression of MAPK3 proteinPMID:19428505
Mapk3increases phosphorylationEXP 6480464CTDCisplatin results in increased phosphorylation of MAPK3 proteinPMID:16154539
Mapk3multiple interactionsEXP 6480464CTDThymic Factor, Circulating inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]PMID:16154539
Mapk3affects activityISOMAPK3 (Homo sapiens)6480464CTDCisplatin affects the activity of MAPK3 proteinPMID:21107699
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCisplatin results in decreased phosphorylation of MAPK3 proteinPMID:23956100
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDCisplatin results in increased activity of MAPK3 proteinPMID:20106947
Mapk3increases activityISOMapk3 (Mus musculus)6480464CTDCisplatin results in increased activity of MAPK3 proteinPMID:21633170
Mapk3increases expressionISOMAPK3 (Homo sapiens)6480464CTDCisplatin results in increased expression of MAPK3 proteinPMID:20309937
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCisplatin results in increased phosphorylation of MAPK3 proteinPMID:15843040 PMID:21444628 PMID:21603599 PMID:21742020 PMID:29471006 PMID:31153982 PMID:32762018
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of MAPK3 proteinPMID:16386719 PMID:18956176 PMID:31153982 PMID:31306688 PMID:32504734 PMID:32991863
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein; [Cisplatin co-treated with Quercetin] results in decreased phosphorylation of MAPK3 protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in decreased phosphorylation of MAPK3 protein; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [Sorafenib co-treated with Cisplatin] results in decreased phosphorylation of MAPK3 protein; astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein; Fluorouracil inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; mirdametinib inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; U 0126 analog inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]PMID:12663670 PMID:15843040 PMID:18819900 PMID:20106947 PMID:21130731 PMID:21444628 PMID:21493726 PMID:21618587 PMID:21742020 PMID:21996734 PMID:25770930 PMID:27514524 PMID:29471006 PMID:31153982
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDanemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; bicyclol inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Catechin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein; hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; IL6 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; N-acetyl glycine cysteine amide inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; N-acetyl-Cys-Gly-Pro-Cys-amide inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; PRKCD affects the reaction [Cisplatin results in increased activity of MAPK3 protein]PMID:16386719 PMID:18956176 PMID:20883750 PMID:21570986 PMID:21633170 PMID:31153982 PMID:31306688 PMID:32504734 PMID:32991863
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