GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | decreases expression | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of MAPK3 protein | PMID:19428505 | Mapk3 | increases phosphorylation | EXP | | 6480464 | CTD | Cisplatin results in increased phosphorylation of MAPK3 protein | PMID:16154539 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | Thymic Factor, Circulating inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] | PMID:16154539 | Mapk3 | affects activity | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Cisplatin affects the activity of MAPK3 protein | PMID:21107699 | Mapk3 | decreases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased phosphorylation of MAPK3 protein | PMID:23956100 | Mapk3 | increases activity | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased activity of MAPK3 protein | PMID:20106947 | Mapk3 | increases activity | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased activity of MAPK3 protein | PMID:21633170 | Mapk3 | increases expression | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of MAPK3 protein | PMID:20309937 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased phosphorylation of MAPK3 protein | PMID:15843040 PMID:21444628 PMID:21603599 PMID:21742020 PMID:29471006 PMID:31153982 PMID:32762018 | Mapk3 | increases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased phosphorylation of MAPK3 protein | PMID:16386719 PMID:18956176 PMID:31153982 PMID:31306688 PMID:32504734 PMID:32991863 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein; [Cisplatin co-treated with Quercetin] results in decreased phosphorylation of MAPK3 protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in decreased phosphorylation of MAPK3 protein; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [Sorafenib co-treated with Cisplatin] results in decreased phosphorylation of MAPK3 protein; astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein; Fluorouracil inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; mirdametinib inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; U 0126 analog inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] | PMID:12663670 PMID:15843040 PMID:18819900 PMID:20106947 PMID:21130731 PMID:21444628 PMID:21493726 PMID:21618587 PMID:21742020 PMID:21996734 PMID:25770930 PMID:27514524 PMID:29471006 PMID:31153982 | Mapk3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; bicyclol inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Catechin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein; hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; IL6 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; N-acetyl glycine cysteine amide inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; N-acetyl-Cys-Gly-Pro-Cys-amide inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; PRKCD affects the reaction [Cisplatin results in increased activity of MAPK3 protein] | PMID:16386719 PMID:18956176 PMID:20883750 PMID:21570986 PMID:21633170 PMID:31153982 PMID:31306688 PMID:32504734 PMID:32991863 | |
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