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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:75045
Term: dabrafenib
Definition: An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Chemical ID: MESH:C561627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDdabrafenib results in increased phosphorylation of MAPK3 proteinPMID:31962201
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[KRAS protein affects the susceptibility to dabrafenib] which affects the phosphorylation of MAPK3 protein; dabrafenib inhibits the reaction [Polyphosphates results in increased phosphorylation of MAPK3 protein]; MAPK3 protein modified form inhibits the reaction [BRAF protein mutant form results in increased susceptibility to dabrafenib]; SRPIN340 inhibits the reaction [dabrafenib results in increased phosphorylation of MAPK3 protein]PMID:26978007 PMID:27222248 PMID:27458080 PMID:31962201
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