Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:5759
Term: Honokiol
Definition: A biphenyl that has formula C18H18O2.
Chemical ID: MESH:C005499
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDhonokiol results in increased phosphorylation of MAPK3 proteinPMID:33550458
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDhonokiol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [honokiol results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [honokiol results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [honokiol results in increased phosphorylation of MAPK3 protein]PMID:21147091 PMID:25980585 PMID:33550458
Go Back to source page   Continue to Ontology report