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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects expressionEXP 6480464CTDCadmium Chloride affects the expression of MAPK3 proteinPMID:17159273
Mapk3decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of MAPK3 mRNAPMID:18636176
Mapk3decreases phosphorylationEXP 6480464CTDCadmium Chloride results in decreased phosphorylation of MAPK3 proteinPMID:25981801 PMID:29214744
Mapk3increases activityEXP 6480464CTDCadmium Chloride results in increased activity of MAPK3 proteinPMID:10637132 PMID:12717738 PMID:15252869 PMID:18629305
Mapk3increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of MAPK3 proteinPMID:18021293 PMID:19233221 PMID:21933187 PMID:23405080 PMID:23876460 PMID:24111524 PMID:24401988 PMID:35122928
Mapk3multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; PPP2CA inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]PMID:11880281 PMID:12717738 PMID:15252869 PMID:18021293 PMID:18629305 PMID:18703135 PMID:19233221 PMID:20829427 PMID:21544200 PMID:21933187 PMID:23405080 PMID:23876460 PMID:24111524 PMID:24401988 PMID:34510229 PMID:9822662
Mapk3affects activityISOMAPK3 (Homo sapiens)6480464CTDCadmium Chloride affects the activity of MAPK3 proteinPMID:11678615
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDCadmium Chloride results in decreased phosphorylation of MAPK3 proteinPMID:17707671 PMID:28666365
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDCadmium Chloride results in increased activity of MAPK3 proteinPMID:19429262 PMID:23485651
Mapk3increases activityISOMapk3 (Mus musculus)6480464CTDCadmium Chloride results in increased activity of MAPK3 proteinPMID:18629305 PMID:18850067
Mapk3increases expressionISOMAPK3 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of MAPK3 mRNA; Cadmium Chloride results in increased expression of MAPK3 protein; Cadmium Chloride results in increased expression of MAPK3 protein modified formPMID:24527689 PMID:27510461 PMID:32512071 PMID:33129824
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of MAPK3 proteinPMID:10753958 PMID:10874044 PMID:16264267 PMID:16959797 PMID:17125913 PMID:18021293 PMID:19041697 PMID:19573589 PMID:21219922 PMID:21697648 PMID:21809093 PMID:22521884 PMID:25744307 PMID:26385184 PMID:28288823 PMID:30682495 PMID:35122928
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDCadmium Chloride results in increased phosphorylation of MAPK3 proteinPMID:11858940 PMID:18348256 PMID:20525538 PMID:22314386 PMID:30399392
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone promotes the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Cadmium Chloride; [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of MAPK3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein; Acetylcysteine affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride promotes the reaction [Buthionine Sulfoximine results in decreased expression of and results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK3 protein; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; diacetyldichlorofluorescein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; EGFR mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; EGFR protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; GPER1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; KRAS protein promotes the reaction [Cadmium Chloride results in increased expression of MAPK3 protein modified form]; KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]]; U 0126 inhibits the reaction [Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]PMID:14610070 PMID:16843830 PMID:16959797 PMID:17125913 PMID:18703135 PMID:19041697 PMID:19327394 PMID:19429262 PMID:21219922 PMID:21544200 PMID:21697648 PMID:21984483 PMID:22019892 PMID:25744307 PMID:26385184 PMID:27071941 PMID:27510461 PMID:28949029 PMID:30682495 PMID:31468104 PMID:31860779 PMID:33818655 PMID:34510229 PMID:34580807 PMID:35122928
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein] which results in increased expression of MT2; [[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein; [Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; [MAPK1 protein co-treated with MAPK3 protein] affects the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [MT1 co-treated with Cadmium Chloride] affects the phosphorylation of MAPK3 protein; [MT2 co-treated with Cadmium Chloride] affects the phosphorylation of MAPK3 protein; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [SU 6656 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with Cadmium Chloride] results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; HTT gene mutant form promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; LL Z1640-2 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK3 protein affects the reaction [Cadmium Chloride affects the localization of BACH1 protein]; Silymarin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]PMID:11678596 PMID:11858940 PMID:11958953 PMID:14504288 PMID:15081267 PMID:16728380 PMID:18348256 PMID:18506790 PMID:18629305 PMID:18850067 PMID:21544200 PMID:23376140 PMID:27432484 PMID:30399392 PMID:37261864
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