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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of MAPK3 mRNAPMID:34037972
Mapk3increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of MAPK3 protein modified formPMID:23664956
Mapk3increases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK3 proteinPMID:21145380 PMID:24531206
Mapk3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein; HTS 466284 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAPK3 mRNA]PMID:21145380 PMID:23542815 PMID:23832679 PMID:24531206 PMID:34037972
Mapk3decreases activityISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of MAPK3 proteinPMID:11304686 PMID:12296996
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of MAPK3 mRNA; Arsenic Trioxide results in decreased expression of MAPK3 proteinPMID:20458559 PMID:27794399
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased phosphorylation of MAPK3 proteinPMID:20592496 PMID:24312908 PMID:27829220 PMID:30014256
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDArsenic Trioxide results in decreased phosphorylation of MAPK3 proteinPMID:21533816 PMID:28454374
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of MAPK3 proteinPMID:12754411 PMID:22963400
Mapk3increases expressionISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MAPK3 proteinPMID:20164150
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK3 proteinPMID:16283431 PMID:16360329 PMID:18636201 PMID:19088370 PMID:21278055 PMID:21594580 PMID:21649584 PMID:22532027 PMID:24392034 PMID:25758096 PMID:25791921 PMID:25983101 PMID:27794399 PMID:30091188 PMID:32305283 PMID:32683294 PMID:34303041 PMID:34560123 PMID:36509116
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK3 proteinPMID:15688020 PMID:24157283 PMID:32683294 PMID:33462182
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased phosphorylation of MAPK3 protein; [Arsenic Trioxide co-treated with 6,7-dimethoxy-3-phenylquinoxaline] results in decreased activity of MAPK3 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein; [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [IL24 protein co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK3 protein; [Quercetin co-treated with Arsenic Trioxide] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [IGF1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Indomethacin results in decreased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [temsirolimus results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Tunicamycin results in decreased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide promotes the reaction [MAPK3 protein promotes the reaction [FOS protein binds to CDKN1A promoter]]; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein; bisindolylmaleimide I inhibits the reaction [[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Indomethacin inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK3 protein]; KIRA6 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; MAPK3 protein affects the reaction [Arsenic Trioxide results in increased expression of CDC6 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; MT2A protein inhibits the reaction [Arsenic Trioxide results in increased expression of MAPK3 protein modified form]; setanaxib inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; Sorafenib inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK3 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; temsirolimus inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]PMID:14610070 PMID:15580305 PMID:15723287 PMID:15961274 PMID:16283431 PMID:16328441 PMID:16445569 PMID:17050201 PMID:17237268 PMID:18281123 PMID:18299328 PMID:18359480 PMID:18387645 PMID:18636201 PMID:18822310 PMID:19088370 PMID:20200477 PMID:20605902 PMID:20615082 PMID:20799280 PMID:20862710 PMID:21078271 PMID:21594580 PMID:21649584 PMID:21889928 PMID:22532027 PMID:22963400 PMID:23041229 PMID:23253724 PMID:23664956 PMID:24312908 PMID:24392034 PMID:25758096 PMID:25791921 PMID:32305283 PMID:32683294 PMID:34560123 PMID:36509116
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; [Arsenic Trioxide co-treated with 6,7-dimethoxy-3-phenylquinoxaline] results in decreased activity of MAPK3 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK3 protein]PMID:17050201 PMID:21533816 PMID:24157283
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