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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDCurcumin results in decreased phosphorylation of MAPK3 proteinPMID:17965732 PMID:18332871
Mapk3multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]PMID:11981161 PMID:16934299 PMID:17372590 PMID:18784349 PMID:19175364 PMID:26713546 PMID:29723552
Mapk3decreases activityISOMAPK3 (Homo sapiens)6480464CTDCurcumin results in decreased activity of MAPK3 proteinPMID:21493726
Mapk3decreases expressionISOMAPK3 (Homo sapiens)6480464CTDCurcumin results in decreased expression of MAPK3 proteinPMID:18555241
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCurcumin results in decreased phosphorylation of MAPK3 proteinPMID:19383353
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDCurcumin results in decreased phosphorylation of MAPK3 proteinPMID:34272803
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCurcumin results in increased phosphorylation of MAPK3 proteinPMID:18316600 PMID:34634291
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDCurcumin results in increased phosphorylation of MAPK3 proteinPMID:17535857
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]PMID:18214481 PMID:18357586 PMID:19074641 PMID:19383353 PMID:20605902 PMID:20727180 PMID:21493726 PMID:21810436 PMID:22142850 PMID:24307199 PMID:25866362 PMID:34634291 PMID:35752269
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]PMID:11035063 PMID:18321868 PMID:19501152 PMID:26191140 PMID:31081568 PMID:33617879 PMID:34272803
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