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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects expressionISOMAPK3 (Homo sapiens)6480464CTDCannabidiol affects the expression of MAPK3 proteinPMID:26504004
Mapk3affects phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCannabidiol affects the phosphorylation of MAPK3 proteinPMID:32060308
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCannabidiol results in increased phosphorylation of MAPK3 proteinPMID:28601556 PMID:33872753
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[Cannabidiol co-treated with Dronabinol] results in increased phosphorylation of MAPK3 protein; [Cannabidiol co-treated with moringin] results in increased expression of MAPK3 mRNA; [Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK3 protein; Cannabidiol results in decreased phosphorylation of and results in decreased expression of MAPK3 protein modified form; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK3 protein]; iodopravadoline inhibits the reaction [Cannabidiol results in increased phosphorylation of MAPK3 protein]; tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK3 protein]; VER 155008 affects the reaction [Cannabidiol affects the expression of MAPK3 protein]PMID:26504004 PMID:30096889 PMID:32060308 PMID:33872753 PMID:34575494 PMID:37567336
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDCannabidiol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]PMID:30033591
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