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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDCelecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]PMID:18988310
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCelecoxib analog results in decreased phosphorylation of MAPK3 protein; Celecoxib results in decreased phosphorylation of MAPK3 proteinPMID:19682443
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDCelecoxib analog results in increased phosphorylation of MAPK3 proteinPMID:15499625
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK3 proteinPMID:16463383
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDCelecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK3 protein]PMID:32416088
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