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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of MAPK3 mRNAPMID:34747641
Mapk3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MAPK3 mRNAPMID:21215274
Mapk3increases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 proteinPMID:30621213
Mapk3multiple interactionsEXP 6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MAPK3 protein]; AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MAPK3 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]PMID:21215274 PMID:23639626
Mapk3affects expressionISOMapk3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MAPK3 mRNAPMID:21570461 PMID:24680724
Mapk3increases activityISOMAPK3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased activity of MAPK3 proteinPMID:27117977
Mapk3increases activityISOMapk3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased activity of MAPK3 proteinPMID:10037446
Mapk3increases expressionISOMapk3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MAPK3 mRNAPMID:28836330
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 proteinPMID:15313166 PMID:19751709 PMID:23228475 PMID:24469321 PMID:26971374
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 proteinPMID:20181658 PMID:20450880 PMID:25194622
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; EGFR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; KN 62 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK3 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 proteinPMID:11309286 PMID:12668121 PMID:17223712 PMID:19578757 PMID:19962423 PMID:21807014 PMID:24469321 PMID:27117977
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA]; Calcium deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein; Tetradecanoylphorbol Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]PMID:10037446 PMID:12213569 PMID:12758056 PMID:19555203 PMID:19782052 PMID:20450880 PMID:25194622 PMID:28836330 PMID:9664232
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