A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID:
MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MAPK3 protein]; AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MAPK3 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; EGFR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; KN 62 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK3 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA]; Calcium deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; MAPK3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein; Tetradecanoylphorbol Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]