Abcb1a (ATP binding cassette subfamily B member 1A) - Rat Genome Database

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Gene: Abcb1a (ATP binding cassette subfamily B member 1A) Rattus norvegicus
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Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
RGD ID: 619951
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to lipid; and response to alkaloid. Located in apical plasma membrane and brush border membrane. Biomarker of brain disease (multiple); end stage renal disease; human immunodeficiency virus infectious disease; liver disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); PARTICIPATES IN axitinib pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; INTERACTS WITH (+)-isoborneol; (+)-pilocarpine; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abcb1; ATP binding cassette subfamily B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; Mdr1a; multiple drug resistant 1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcb1aem1Sage   Abcb1aem2Sage   Abcb1aem3Sage  
Genetic Models: WI-Abcb1aem2Sage WI-Abcb1aem3Sage SD-Abcb1aem1Sage -/- SD-Abcb1aem1Sage Abcg2em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,312,403 - 26,488,456 (-)NCBIGRCr8
mRatBN7.2425,357,467 - 25,529,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,355,700 - 30,438,098 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,281,938 - 26,364,336 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,656,062 - 24,738,283 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,339,829 - 22,517,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,276,390 - 22,448,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,709,855 - 21,796,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,709,854 - 21,796,626 (+)NCBI
Celera420,849,575 - 20,934,573 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Anthracycline-induced Cardiotoxicity  (ISO)
antisocial personality disorder  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
cannabis dependence  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
COVID-19  (ISO)
Critical Illness  (ISO)
Crohn's disease  (ISO)
cryoglobulinemia  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
disease of mental health  (ISO)
Disease Progression  (ISO)
drug dependence  (ISO)
Drug Overdose  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalitis  (IEP)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
Eosinophilia  (ISO)
epilepsy  (IEP,ISO)
Escherichia Coli Infections  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Diabetes Mellitus  (IAGP,IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
familial hyperlipidemia  (ISO)
familial Mediterranean fever  (ISO)
familial temporal lobe epilepsy 3  (ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (IEP)
Genetic Predisposition to Disease  (ISO)
Genetic Translocation  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
heroin dependence  (ISO)
human immunodeficiency virus infectious disease  (IEP,ISO)
idiopathic generalized epilepsy  (ISO)
Inflammation  (IEP)
inflammatory bowel disease 13  (ISO,ISS)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Latent Tuberculosis  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Nausea  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
neutropenia  (ISO)
obstructive sleep apnea  (IEP)
opiate dependence  (ISO)
Orthostatic Hypotension  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
Postoperative Pain  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
ST Elevation Myocardial Infarction  (ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (IEP)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
visual epilepsy  (IEP)
Vomiting  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-artemisinin  (ISO)
(+)-isoborneol  (EXP)
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-sesamin  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-antofine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(E,E)-germacrone  (ISO)
(E,E)-hydramethylnon  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-glaucine  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,9-dideoxyforskolin  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
16alpha,17beta-Estriol 17-(beta-D-glucuronide)  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-indole  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methyl-1H-indole  (ISO)
2-nitrofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-Methoxyflavone  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
abamectin  (EXP,ISO)
abietic acid  (ISO)
acenocoumarol  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aliskiren  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide  (ISO)
alpha-tocotrienol  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP,ISO)
ammonium chloride  (EXP)
Amorphigenin  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
amprenavir  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
auraptene  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azelastine  (ISO)
Azidopine  (ISO)
baicalein  (ISO)
barnidipine  (ISO)
beclomethasone  (ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
bepridil  (ISO)
berberine  (EXP)
bergomottin  (ISO)
beryllium difluoride  (ISO)
beta-pinene  (ISO)
beta-tocotrienol  (ISO)
betulin  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromocriptine  (EXP)
budesonide  (ISO)
bufalin  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcein  (ISO)
calcein am  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
cardenolides  (ISO)
carmustine  (ISO)
carvedilol  (EXP,ISO)
celecoxib  (ISO)
cepharanthine  (ISO)
cerivastatin  (ISO)
cetirizine  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroform  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
Ciclesonide  (ISO)
cilastatin  (ISO)
cinchonine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citronellal  (ISO)
citronellol  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
clopidogrel  (EXP,ISO)
closantel  (ISO)
clotrimazole  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coptisine  (EXP)
cortisol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyazofamid  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
Cymarin  (ISO)
cyproconazole  (EXP,ISO)
cytarabine  (ISO)
D-cycloserine  (ISO)
D-glucose  (ISO)
D-mannitol  (EXP)
daidzein  (ISO)
daunorubicin  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desloratadine  (ISO)
Desmethylazelastine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
digoxigenin  (ISO)
digoxin  (EXP,ISO)
diltiazem  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (EXP,ISO)
dioxygen  (ISO)
diphenyl(4-piperidinyl)methanol  (ISO)
disulfiram  (ISO)
domperidone  (ISO)
Doramectin  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
efonidipine hydrochloride  (ISO)
emamectin  (ISO)
emodin  (EXP,ISO)
enasidenib  (ISO)
endosulfan  (ISO)
epinastine  (ISO)
epoxiconazole  (EXP,ISO)
eprinomectin  (ISO)
eriodictyol  (ISO)
erythromycin A  (EXP,ISO)
erythromycin estolate  (EXP)
erythrosin B  (ISO)
estriol  (ISO)
estriol 16-O-(beta-D-glucuronide)  (EXP)
estrone  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenoxycarb  (ISO)
fentanyl  (EXP,ISO)
fenvalerate  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
flavonol  (ISO)
fluoxetine  (EXP)
flupenthixol  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
fluvoxamine  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP,ISO)
fusidic acid  (ISO)
gabapentin  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-terpinene  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
geneticin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gingerol  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside F2  (ISO)
glabridin  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycitein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
griseofulvin  (ISO)
GTP  (ISO)
GW 7647  (EXP,ISO)
haloperidol  (ISO)
heptachlor  (ISO)
huperzine A  (ISO)
hyaluronic acid  (ISO)
hydramethylnon  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
hyperforin  (ISO)
hypericin  (ISO)
ifosfamide  (ISO)
imipenem hydrate  (ISO)
imipramine  (EXP)
indole-3-acetamide  (ISO)
indole-3-methanol  (EXP,ISO)
irinotecan  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
Isosafrole  (ISO)
isotretinoin  (ISO)
isovitexin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferide  (ISO)
kaempferol  (ISO)
kainic acid  (EXP)
kenpaullone  (ISO)
ketamine  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
KT 5720  (ISO)
kuwanone G  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
L-methionine  (EXP,ISO)
lamotrigine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
LCL161  (ISO)
lead(0)  (ISO)
levetiracetam  (EXP,ISO)
levonorgestrel  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lomustine  (ISO)
loperamide  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
macitentan  (ISO)
magnesium atom  (ISO)
malonaldehyde  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
manidipine  (ISO)
mebendazole  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
meloxicam  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
metazachlor  (ISO)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxyfenozide  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methylarsonic acid  (EXP)
metiram  (ISO)
metoclopramide  (ISO)
metolachlor  (ISO)
metronidazole  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
midostaurin  (ISO)
mifepristone  (ISO)
milbemycin  (ISO)
miltefosine  (ISO)
mirtazapine  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
mitoTracker Green FM  (ISO)
mitoxantrone  (ISO)
MK 571  (ISO)
mometasone furoate  (ISO)
morin  (ISO)
morphine  (EXP,ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-desethylamiodarone  (ISO)
N-ethylmaleimide  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
naproxen  (ISO)
naringin  (ISO)
nelfinavir  (ISO)
Nemadectin  (ISO)
neomycin  (ISO)
nevirapine  (EXP)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nifedipine  (ISO)
nilotinib  (ISO)
Nilvadipine  (ISO)
nimesulide  (ISO)
nisoldipine  (ISO)
nobiletin  (ISO)
Nonylphenol  (EXP)
norathyriol  (ISO)
norethisterone  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleoyl ethanolamide  (ISO)
oltipraz  (ISO)
Omadacycline  (ISO)
omeprazole  (EXP,ISO)
ophiobolin A  (ISO)
organophosphorus compound  (ISO)
oroxylin A  (ISO)
ouabain  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paliperidone palmitate  (EXP,ISO)
palmatine  (EXP,ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peruvoside  (ISO)
phalloidin  (EXP)
phenobarbital  (EXP,ISO)
phenols  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
pimecrolimus  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
poly(ethene-1,2-diyl) macromolecule  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP,ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
propranolol  (ISO)
Proscillaridin  (ISO)
Prulifloxacin  (EXP)
psorospermin  (ISO)
puerarin  (ISO)
puromycin  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quercitrin  (ISO)
quetiapine fumarate  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
quinpirole  (EXP)
rac-3,4-methylenedioxy-N-ethylamphetamine  (ISO)
raloxifene  (ISO)
razoxane  (ISO)
rescinnamine  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rhodamine 123  (EXP,ISO)
riddelliine  (EXP)
rifabutin  (ISO)
rifampicin  (EXP,ISO)
rifaximin  (ISO)
risperidone  (EXP,ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rose bengal  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
rutin  (ISO)
Salidroside  (ISO)
saquinavir  (ISO)
sarin  (ISO)
saxitoxin  (ISO)
schaftoside  (ISO)
sciadopitysin  (ISO)
scopolamine  (EXP)
SDZ PSC 833  (EXP,ISO)
Secomilbemycin D  (ISO)
Selamectin  (ISO)
senecionine  (ISO)
sepantronium  (ISO)
sertraline  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silibinin  (ISO)
simvastatin  (ISO)
sinensetin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sotalol  (ISO)
spinosad  (ISO)
spiperone  (EXP)
spironolactone  (ISO)
stavudine  (ISO)
strophanthidin  (ISO)
succimer  (ISO)
sulconazole  (ISO)
sulforaphane  (EXP,ISO)
sulpiride  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
Tariquidar  (ISO)
tartrazine  (ISO)
taurocholic acid  (EXP,ISO)
taxane  (ISO)
tebufenozide  (ISO)
Technetium tc 99m sestamibi  (ISO)
tectochrysin  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
Terfenadine  (ISO)
terpinolene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tiagabine  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
Tocophersolan  (ISO)
tolbutamide  (ISO)
toluene  (EXP)
topiramate  (EXP)
topotecan  (ISO)
trabectedin  (EXP,ISO)
triadimefon  (EXP,ISO)
triamcinolone acetonide  (ISO)
triamterene  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
troleandomycin  (ISO)
trospium chloride  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
veliparib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
withaferin A  (ISO)
xanthenes  (EXP,ISO)
yohimbine  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
carboxylic acid transmembrane transport  (ISO)
cellular hyperosmotic salinity response  (IEP)
cellular response to alkaloid  (IEP)
cellular response to antibiotic  (IEP)
cellular response to borneol  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to external biotic stimulus  (IEP)
cellular response to L-glutamate  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to mycotoxin  (IEP)
cellular response to nonylphenol  (IEP)
cellular response to tumor necrosis factor  (IEP)
ceramide translocation  (ISO)
circadian rhythm  (IEP)
daunorubicin transport  (IMP)
establishment of blood-brain barrier  (IMP)
establishment of blood-retinal barrier  (IMP)
export across plasma membrane  (ISO)
female pregnancy  (IEP)
G2/M transition of mitotic cell cycle  (ISO)
hormone transport  (IDA)
intestinal absorption  (IMP)
lactation  (IEP)
maintenance of blood-brain barrier  (IMP)
negative regulation of sensory perception of pain  (IEP)
phospholipid translocation  (ISO)
placenta development  (IEP)
positive regulation of establishment of Sertoli cell barrier  (IMP)
positive regulation of response to biotic stimulus  (IMP)
positive regulation of response to drug  (IDA,IMP)
protein localization to bicellular tight junction  (IMP)
regulation of chloride transport  (ISO)
regulation of intestinal absorption  (IMP)
regulation of response to osmotic stress  (ISO)
response to alcohol  (IEP)
response to antineoplastic agent  (IEP)
response to cadmium ion  (IEP)
response to codeine  (IEP)
response to cyclosporin A  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to glucagon  (IEP)
response to glycoside  (IEP)
response to hypoxia  (IEP)
response to L-glutamate  (IEP)
response to lipopolysaccharide  (IEP)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to progesterone  (IEP)
response to quercetin  (IEP)
response to thyroxine  (IEP)
response to vitamin A  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IEP)
stem cell proliferation  (ISO)
terpenoid transport  (ISO)
transepithelial transport  (ISO)
transmembrane transport  (IDA)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IDA,ISO)
xenobiotic transport across blood-brain barrier  (IMP,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. null
2. MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine. Aarnoudse AL, etal., Clin Pharmacol Ther. 2006 Oct;80(4):367-74. doi: 10.1016/j.clpt.2006.07.003.
3. A Common mdr1 Gene Polymorphism is Associated With Changes in Linezolid Clearance. Allegra S, etal., Ther Drug Monit. 2018 Oct;40(5):602-609. doi: 10.1097/FTD.0000000000000536.
4. The role of multidrug resistance-1 (MDR1) variants in response to fexofenadine among Jordanians. Alzoubi KH, etal., Int J Clin Pharmacol Ther. 2013 Nov;51(11):880-7. doi: 10.5414/CP201968.
5. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Arana MR, etal., Toxicology. 2017 Sep 1;390:22-31. doi: 10.1016/j.tox.2017.08.007. Epub 2017 Aug 23.
6. Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients. Au A, etal., Biomed Pharmacother. 2014 Apr;68(3):343-9. doi: 10.1016/j.biopha.2014.01.009. Epub 2014 Feb 7.
7. Patterns of P-glycoprotein activity in the nervous system during vincristine-induced neuropathy in rats. Balayssac D, etal., J Peripher Nerv Syst. 2005 Sep;10(3):301-10.
8. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
9. Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. Benyamina A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1270-4. doi: 10.1016/j.pnpbp.2009.07.016. Epub 2009 Jul 20.
10. Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis. Bleier BS Int Forum Allergy Rhinol. 2012 Mar-Apr;2(2):122-5. doi: 10.1002/alr.21004. Epub 2011 Dec 29.
11. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. Booth-Genthe CL, etal., J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):78-89. Epub 2006 Mar 20.
12. Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro. Brocks DR, etal., Can J Physiol Pharmacol. 2014 Feb;92(2):140-8. doi: 10.1139/cjpp-2013-0250.
13. Nephroblastoma: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells. Camassei FD, etal., Am J Clin Pathol. 2002 Mar;117(3):484-90.
14. ABCB1 genotypes predict cyclosporine-related adverse events and kidney allograft outcome. Cattaneo D, etal., J Am Soc Nephrol. 2009 Jun;20(6):1404-15. Epub 2009 May 21.
15. Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood-Brain Barrier. Chaves C, etal., J Pharm Sci. 2015 Nov 10. doi: 10.1002/jps.24697.
16. Coexpression of invasive markers (uPA, CD44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. Chen H, etal., Br J Cancer. 2009 Aug 4;101(3):432-40. Epub 2009 Jul 14.
17. Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Chokkalingam AP, etal., Cancer Causes Control. 2012 Aug;23(8):1367-75. doi: 10.1007/s10552-012-9947-4. Epub 2012 Jun 7.
18. Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Chow EC, etal., Biopharm Drug Dispos. 2010 Jan;31(1):91-108.
19. Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases. Chu X, etal., Mol Pharmacol. 2012 Feb;81(2):220-7. doi: 10.1124/mol.111.074179. Epub 2011 Nov 2.
20. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Cizmarikova M, etal., Pharmacogenomics J. 2009 Sep 15.
21. ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals. Coller JK, etal., Clin Pharmacol Ther. 2006 Dec;80(6):682-90. doi: 10.1016/j.clpt.2006.09.011.
22. Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. Cusato J, etal., Pharmacogenomics. 2017 May;18(7):607-611. doi: 10.2217/pgs-2016-0040. Epub 2017 Apr 28.
23. Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies. Dash RP, etal., Eur J Pharmacol. 2015 Nov 15;767:67-76. doi: 10.1016/j.ejphar.2015.10.009. Epub 2015 Oct 10.
24. A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature. Delaunay JL, etal., Hepatology. 2009 Apr;49(4):1218-27. doi: 10.1002/hep.22775.
25. Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines. Demeuse P, etal., J Neurochem. 2004 Jan;88(1):23-31.
26. Identification of distinct P-glycoprotein gene sequences in rat. Deuchars KL, etal., Biochim Biophys Acta 1992 Mar 24;1130(2):157-65.
27. Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe. Dhoro M, etal., Curr HIV Res. 2013 Sep;11(6):481-90.
28. Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever. Dogruer D, etal., Genet Mol Res. 2013 Jan 24;12(3):3521-8. doi: 10.4238/2013.January.24.2.
29. Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat. Donald S, etal., Cancer Res 2002 Aug 1;62(15):4256-62.
30. Influence of intermittent hypoxia on myocardial and hepatic P-glycoprotein expression in a rodent model. Dopp JM, etal., Pharmacotherapy. 2009 Apr;29(4):365-72.
31. Drug resistance and sensitivity of germ cell testicular tumors: evaluation of clinical relevance of MDR1/Pgp, p53, and metallothionein (MT) proteins. Eid H, etal., Anticancer Res. 1998 Jul-Aug;18(4C):3059-64.
32. Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder. Enabah D, etal., Am J Drug Alcohol Abuse. 2014 Jul;40(4):317-20. doi: 10.3109/00952990.2014.925468. Epub 2014 Jun 20.
33. Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy. Erdilyi DJ, etal., Pharmacogenomics J. 2008 Oct;8(5):321-7.
34. Borneol Depresses P-Glycoprotein Function by a NF-kappaB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Fan X, etal., Int J Mol Sci. 2015 Nov 18;16(11):27576-88. doi: 10.3390/ijms161126051.
35. Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats. Fuchs H, etal., Drug Metab Dispos. 2014 Oct;42(10):1761-5. doi: 10.1124/dmd.114.058545. Epub 2014 Jul 22.
36. Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats. Fujii S, etal., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4650-8. doi: 10.1167/iovs.13-13819.
37. ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population. Fukunaga K, etal., BMC Genet. 2016 Jun 13;17(1):79. doi: 10.1186/s12863-016-0390-5.
38. Common ABCB1 polymorphisms in Greek patients with chronic hepatitis C infection: A comparison with hyperlipidemic patients and the general population. Gbandi E, etal., Pharmacol Rep. 2016 Apr;68(2):476-82. doi: 10.1016/j.pharep.2015.10.009. Epub 2015 Nov 6.
39. Endotoxin mediated downregulation of hepatic drug transporters in HIV-1 transgenic rats. Ghoneim RH and Piquette-Miller M, Drug Metab Dispos. 2016 Mar 14. pii: dmd.115.067827.
40. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Gilchrist SE and Alcorn J, Fundam Clin Pharmacol. 2009 Aug 21.
41. Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Goralski KB, etal., Br J Pharmacol. 2003 May;139(1):35-48.
42. Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitis without nasal polyps. Gunel C, etal., Am J Rhinol Allergy. 2014 Mar-Apr;28(2):99-102. doi: 10.2500/ajra.2014.28.4011.
43. P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Guner YS, etal., Lab Invest. 2011 Nov;91(11):1668-79. doi: 10.1038/labinvest.2011.113. Epub 2011 Jul 25.
44. Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum. Gupta H, etal., PLoS One. 2017 Apr 19;12(4):e0175702. doi: 10.1371/journal.pone.0175702. eCollection 2017.
45. Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats. Hammad AM, etal., Mol Neurobiol. 2019 Mar;56(3):1921-1932. doi: 10.1007/s12035-018-1153-2. Epub 2018 Jul 6.
46. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Han JY, etal., Cancer. 2007 Jul 1;110(1):138-47.
47. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Hardwick RN, etal., Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23.
48. Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone. Hassan HE, etal., Drug Metab Dispos. 2013 May;41(5):1060-9. doi: 10.1124/dmd.112.050401. Epub 2013 Feb 25.
49. Influence of a time-restricted feeding schedule on the daily rhythm of abcb1a gene expression and its function in rat intestine. Hayashi Y, etal., J Pharmacol Exp Ther. 2010 Nov;335(2):418-23. Epub 2010 Jul 28.
50. Ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells. He Y, etal., J Exp Clin Cancer Res. 2011 Oct 28;30:104. doi: 10.1186/1756-9966-30-104.
51. Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha. Heemskerk S, etal., J Biomed Biotechnol. 2010;2010:525180. doi: 10.1155/2010/525180. Epub 2010 Mar 9.
52. Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats. Higashi K, etal., Drug Metab Pharmacokinet. 2013;28(1):44-52. Epub 2012 Jul 10.
53. P-glycoprotein expression and localization in the rat uterus throughout gestation and labor. Huang QT, etal., Reproduction. 2016 Sep;152(3):195-204. doi: 10.1530/REP-16-0161. Epub 2016 Jun 22.
54. Changes of Absorptive and Secretory Transporting System of (1 --> 3) beta-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. Iida A, etal., Eur J Drug Metab Pharmacokinet. 2015 Mar;40(1):29-38. doi: 10.1007/s13318-014-0174-0. Epub 2014 Feb 11.
55. Verapamil and rifampin effect on p-glycoprotein expression in hepatocellular carcinoma. Jalali A, etal., Jundishapur J Nat Pharm Prod. 2014 Oct 10;9(4):e17741. eCollection 2014 Nov.
56. Regulation and characterization of the ATP-binding cassette transporter-B1 in the epididymis and epididymal spermatozoa of the rat. Jones SR and Cyr DG, Toxicol Sci. 2011 Feb;119(2):369-79. doi: 10.1093/toxsci/kfq318. Epub 2010 Oct 20.
57. Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication. Karaca RO, etal., Basic Clin Pharmacol Toxicol. 2017 Feb;120(2):199-206. doi: 10.1111/bcpt.12667. Epub 2016 Nov 2.
58. ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Karlsson L, etal., Int J Legal Med. 2013 May;127(3):579-86. doi: 10.1007/s00414-013-0849-0. Epub 2013 Mar 21.
59. The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome. Kiaco K, etal., Malar J. 2017 Sep 21;16(1):383. doi: 10.1186/s12936-017-2006-6.
60. Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy. Kim KP, etal., Cancer Chemother Pharmacol. 2012 May;69(5):1221-7. doi: 10.1007/s00280-011-1816-4. Epub 2012 Jan 20.
61. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Kong LL, etal., Sci Rep. 2015 Jul 2;5:11747. doi: 10.1038/srep11747.
62. The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children. Kopriva F, etal., J Asthma. 2009 May;46(4):366-70.
63. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Koraichi F, etal., Toxicology. 2013 Aug 9;310:29-38. doi: 10.1016/j.tox.2013.05.002. Epub 2013 May 22.
64. Accumulation of murine amyloid-ß mimics early Alzheimer's disease. Krohn M, etal., Brain. 2015 Aug;138(Pt 8):2370-82. doi: 10.1093/brain/awv137. Epub 2015 May 18.
65. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. Kuo TC, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):736-44. Epub 2009 Jun 23.
66. Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Kwan P, etal., Epilepsia. 2002 Nov;43(11):1318-23.
67. Moving toward personalized medicine in the methadone maintenance treatment program: a pilot study on the evaluation of treatment responses in Taiwan. Lee HY, etal., Biomed Res Int. 2013;2013:741403. doi: 10.1155/2013/741403. Epub 2013 Dec 16.
68. Association between the c.3751G>a genetic variant of MDR1 and hepatocellular carcinoma risk in a Chinese Han population. Li XF, etal., Asian Pac J Cancer Prev. 2013;14(9):5361-5. doi: 10.7314/apjcp.2013.14.9.5361.
69. Expression of HIF-1alpha and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone. Li Y, etal., Neurol Sci. 2014 Aug;35(8):1203-8. doi: 10.1007/s10072-014-1681-0. Epub 2014 Mar 4.
70. Ouabain-induced alterations in ABCB1 of mesenteric lymph nodes and thymocytes of rats and mice. Lima DB, etal., Oncol Lett. 2016 Dec;12(6):5275-5280. doi: 10.3892/ol.2016.5366. Epub 2016 Nov 8.
71. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Liu H, etal., Brain Res. 2006 Dec 6;1123(1):245-52. Epub 2006 Oct 30.
72. Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats. Liu X, etal., Drug Metab Dispos. 2014 Apr;42(4):482-91. doi: 10.1124/dmd.113.055590. Epub 2014 Jan 7.
73. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
74. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Maeng HJ, etal., Drug Metab Dispos. 2007 Nov;35(11):1996-2005. Epub 2007 Jul 30.
75. Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis. Mignogna C, etal., BMC Cancer. 2006 Dec 19;6:293.
76. P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gphigh cells and correlates with HIV-1 viral load. Minuesa G, etal., J Antimicrob Chemother. 2016 Oct;71(10):2782-92. doi: 10.1093/jac/dkw215. Epub 2016 Jun 21.
77. Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters. Mrozikiewicz PM, etal., Acta Pharm. 2014 Jun;64(2):223-32. doi: 10.2478/acph-2014-0020.
78. Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats. Nagaya Y, etal., Drug Metab Pharmacokinet. 2016 Feb;31(1):57-66. doi: 10.1016/j.dmpk.2015.10.003. Epub 2015 Nov 5.
79. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Nakamura Y, etal., Int J Cancer. 2006 May 15;118(10):2448-54.
80. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Narang VS, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C440-50. Epub 2008 Jun 4.
81. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
82. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
83. MDR1, MRP1 and MRP2 genotypes and in vitro chemosensitivity in Japanese patients with colorectal adenocarcinomas. Nishioka C, etal., Kobe J Med Sci. 2004;50(5-6):181-8.
84. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Novotna M, etal., Reprod Toxicol. 2004 Aug-Sep;18(6):785-92.
85. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
86. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
87. Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Pajic M, etal., Cancer Res. 2009 Aug 15;69(16):6396-404. Epub 2009 Aug 4.
88. MDR1 gene C3435T polymorphism in chronic hepatitis C patients. Parsa Nahad M, etal., Microb Pathog. 2018 Jan;114:63-67. doi: 10.1016/j.micpath.2017.11.017. Epub 2017 Nov 16.
89. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. Patel VA, etal., J Biol Chem 2002 Oct 11;277(41):38915-20.
90. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
91. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
92. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
93. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Potocnik U, etal., Genes Immun. 2004 Nov;5(7):530-9.
94. GOA pipeline RGD automated data pipeline
95. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
96. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
97. Comprehensive gene review and curation RGD comprehensive gene curation
98. Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model. Robillard KR, etal., Biochem Biophys Res Commun. 2014 Feb 21;444(4):531-6. doi: 10.1016/j.bbrc.2014.01.092. Epub 2014 Jan 25.
99. Possible association of rare polymorphism in the ABCB1 gene with rifampin and ethambutol drug-resistant tuberculosis. Rodriguez-Castillo JA, etal., Tuberculosis (Edinb). 2015 Sep;95(5):532-7. doi: 10.1016/j.tube.2015.04.004. Epub 2015 May 20.
100. MDR1 gene polymorphisms may be associated with Behcet's disease and its colchicum treatment response. Rustemoglu A, etal., Gene. 2012 Sep 1;505(2):333-9. doi: 10.1016/j.gene.2012.05.040. Epub 2012 Jun 15.
101. Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever. Rustemoglu A, etal., Xenobiotica. 2014 Oct;44(10):933-40. doi: 10.3109/00498254.2014.915071. Epub 2014 Apr 28.
102. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Salimizand H, etal., Tumour Biol. 2016 Jan;37(1):791-8. doi: 10.1007/s13277-015-3874-4. Epub 2015 Aug 7.
103. Effects of rifampicin, dexamethasone, St. John's Wort and Thyroxine on maternal and foetal expression of Abcb1 and organ distribution of talinolol in pregnant rats. Salje K, etal., Basic Clin Pharmacol Toxicol. 2012 Aug;111(2):99-105. doi: 10.1111/j.1742-7843.2012.00866.x. Epub 2012 Mar 14.
104. Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior. Salvatore JE, etal., Transl Psychiatry. 2015 Apr 28;5(4):e558. doi: 10.1038/tp.2015.36.
105. C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers. Sałagacka A, etal., Pharmacol Rep. 2011;63(4):992-8. doi: 10.1016/s1734-1140(11)70615-6.
106. Modulation of gene expression profiles by hyperosmolarity and insulin. Schafer C, etal., Cell Physiol Biochem. 2007;20(5):369-86.
107. CpG hypomethylation of MDR1 gene in tumor and serum of invasive ductal breast carcinoma patients. Sharma G, etal., Clin Biochem. 2009 Oct 29.
108. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. Siddiqui A, etal., N Engl J Med 2003 Apr 10;348(15):1442-8.
109. Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. Siegsmund M, etal., J Am Soc Nephrol. 2002 Jul;13(7):1847-54.
110. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Soares RV, etal., Fundam Clin Pharmacol. 2016 Apr;30(2):107-116. doi: 10.1111/fcp.12175. Epub 2016 Feb 4.
111. Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat. Su L, etal., Cell Death Dis. 2017 Sep 7;8(9):e3038. doi: 10.1038/cddis.2017.435.
112. Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine. Suzuki H, etal., Biol Pharm Bull. 2010;33(4):677-82.
113. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate. Suzuki M, etal., Xenobiotica. 2014 Nov;44(11):1039-45. doi: 10.3109/00498254.2014.920551. Epub 2014 May 19.
114. ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients. Swart M, etal., Front Genet. 2012 Nov 5;3:236. doi: 10.3389/fgene.2012.00236. eCollection 2012.
115. Effect of promoter methylation of multidrug resistance 1 (MDR1) gene in gastric carcinogenesis. Tahara T, etal., Anticancer Res. 2009 Jan;29(1):337-41.
116. eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells. Tang XH, etal., PLoS One. 2015 May 11;10(5):e0125389. doi: 10.1371/journal.pone.0125389. eCollection 2015.
117. Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Thevenod F, etal., Biometals. 2006 Nov 29;.
118. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
119. 5-HT2A receptor SPECT imaging with R91150 under P-gp inhibition with tariquidar: More is better? Tsartsalis S, etal., Nucl Med Biol. 2016 Jan;43(1):81-8. doi: 10.1016/j.nucmedbio.2015.09.003. Epub 2015 Sep 11.
120. Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. Tufan A, etal., J Rheumatol. 2007 Jul;34(7):1540-4. Epub 2007 Jun 15.
121. Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney. Uchida Y, etal., J Pharm Sci. 2015 Sep 14. doi: 10.1002/jps.24645.
122. Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
123. Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis. Uno S, etal., Drug Metab Pharmacokinet. 2007 Aug;22(4):313-21.
124. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. van Vliet E, etal., Epilepsy Res 2004 Jul-Aug;60(2-3):203-13.
125. Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type. Wang B, etal., Am J Hematol. 2008 Oct;83(10):795-9. doi: 10.1002/ajh.21256.
126. Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo. Wang L, etal., Toxicol Appl Pharmacol. 2014 Jun 1;277(2):146-54. doi: 10.1016/j.taap.2014.03.013. Epub 2014 Mar 26.
127. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Wang Y, etal., Molecules. 2015 Dec 29;21(1). pii: E46. doi: 10.3390/molecules21010046.
128. Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males. Wang Y, etal., Oncotarget. 2017 May 16;8(20):33770-33778. doi: 10.18632/oncotarget.16809.
129. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Wojnowski L, etal., Circulation. 2005 Dec 13;112(24):3754-62. Epub 2005 Dec 5.
130. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Yamada T, etal., Cancer Res. 2003 Mar 1;63(5):895-901.
131. Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats. Yan YE, etal., Acta Pharmacol Sin. 2005 Nov;26(11):1387-94.
132. Association analysis between MDR1 gene polymorphisms and risk of hepatocellular carcinoma in Chinese population. Yang D, etal., Biomarkers. 2013 May;18(3):236-41. doi: 10.3109/1354750X.2013.773079. Epub 2013 Mar 15.
133. Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. Yokogawa K, etal., Biochem Pharmacol. 2002 Feb 15;63(4):777-83.
134. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Yu N, etal., Neurochem Res. 2017 Aug;42(8):2167-2177. doi: 10.1007/s11064-017-2224-x. Epub 2017 Mar 16.
135. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.
136. Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2013 Jun;41(6):1174-8. doi: 10.1124/dmd.113.051409. Epub 2013 Apr 8.
137. Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Zgheib NK, etal., Pharmacogenet Genomics. 2014 Aug;24(8):387-96. doi: 10.1097/FPC.0000000000000069.
138. Relationship between ABCB1 polymorphisms, thromboelastography and risk of bleeding events in clopidogrel-treated patients with ST-elevation myocardial infarction. Zhang JH, etal., Thromb Res. 2014 Nov;134(5):970-5. doi: 10.1016/j.thromres.2014.08.017. Epub 2014 Aug 29.
139. Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats. Zhang LL, etal., Acta Pharmacol Sin. 2011 Jul;32(7):956-66. doi: 10.1038/aps.2011.33. Epub 2011 Jun 20.
140. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism. Zhu HJ and Liu GQ, Life Sci. 2004 Jul 30;75(11):1313-22.
141. ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort. Zhu P, etal., PLoS One. 2013;8(1):e55197. doi: 10.1371/journal.pone.0055197. Epub 2013 Jan 25.
Additional References at PubMed
PMID:7828597   PMID:8104413   PMID:8898203   PMID:11741934   PMID:12068294   PMID:16255849   PMID:16361082   PMID:17709369   PMID:18619525   PMID:18680196   PMID:18760905   PMID:19056867  
PMID:19384922   PMID:21350189   PMID:22015764   PMID:22106313   PMID:22563480   PMID:23376485   PMID:23533145   PMID:25539457   PMID:25986174   PMID:26006083   PMID:26727197   PMID:28587984  
PMID:28757552   PMID:29527534   PMID:33984358   PMID:34255797   PMID:35563868  


Genomics

Comparative Map Data
Abcb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,312,403 - 26,488,456 (-)NCBIGRCr8
mRatBN7.2425,357,467 - 25,529,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,355,700 - 30,438,098 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,281,938 - 26,364,336 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,656,062 - 24,738,283 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,339,829 - 22,517,642 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,276,390 - 22,448,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,709,855 - 21,796,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,709,854 - 21,796,626 (+)NCBI
Celera420,849,575 - 20,934,573 (-)NCBICelera
Cytogenetic Map4q12NCBI
ABCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,503,017 - 87,713,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,503,017 - 87,713,323 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,132,333 - 87,342,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,970,884 - 87,180,500 (-)NCBINCBI36Build 36hg18NCBI36
Build 34786,777,598 - 86,987,215NCBI
Celera781,837,832 - 82,047,176 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef781,744,182 - 81,952,578 (-)NCBIHuRef
CHM1_1787,063,281 - 87,272,756 (-)NCBICHM1_1
T2T-CHM13v2.0788,752,787 - 88,963,178 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,464,691 - 86,673,953 (-)NCBI
Abcb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,617,091 - 8,798,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,710,077 - 8,798,575 (+)EnsemblGRCm39 Ensembl
GRCm3858,567,091 - 8,748,575 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,660,077 - 8,748,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,660,092 - 8,748,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,666,098 - 8,754,525 (+)NCBIMGSCv36mm8
Celera58,580,580 - 8,668,151 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
Abcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554324,911,774 - 5,085,349 (-)NCBIChiLan1.0ChiLan1.0
ABCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,382,570 - 105,590,973 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17153,647,208 - 153,855,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,497,536 - 79,706,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,147,217 - 93,355,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,147,950 - 93,243,238 (-)Ensemblpanpan1.1panPan2
ABCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,644,891 - 13,852,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,542,647 - 13,742,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,216,483 - 13,313,885 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01413,410,127 - 13,507,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,409,565 - 13,507,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11413,613,256 - 13,710,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,339,096 - 13,436,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01413,622,793 - 13,720,201 (-)NCBIUU_Cfam_GSD_1.0
Abcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,693,137 - 26,871,076 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367631,226,482 - 1,297,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367631,225,355 - 1,308,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,049,955 - 93,146,469 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,530,015 - 102,626,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,211,044 - 61,430,691 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,322,748 - 61,529,274 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604242,634,559 - 42,749,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Abcb1a
744 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:218
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000011166
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat

Markers in Region
D4Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,357,584 - 25,357,782 (+)MAPPERmRatBN7.2
Rnor_6.0422,339,947 - 22,340,144NCBIRnor6.0
Rnor_5.0422,276,508 - 22,276,705UniSTSRnor5.0
RGSC_v3.4421,796,313 - 21,796,510UniSTSRGSC3.4
Celera420,849,693 - 20,849,890UniSTS
Cytogenetic Map4q12UniSTS


Genetic Models
This gene Abcb1a is modified in the following models/strains:
WI-Abcb1aem2Sage     WI-Abcb1aem3Sage     SD-Abcb1aem1Sage -/-     SD-Abcb1aem1Sage Abcg2em1Sage    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 31 7 31 3 4 8
Low 27 26 10 12 10 8 11 70 20 30 3 8
Below cutoff 16 4 12 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011166   ⟹   ENSRNOP00000011166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)Ensembl
Rnor_6.0 Ensembl422,339,831 - 22,425,381 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000037712   ⟹   ENSRNOP00000038721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043822   ⟹   ENSRNOP00000042556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl422,134,805 - 22,192,474 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000047126   ⟹   ENSRNOP00000049952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl422,225,461 - 22,307,453 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082359   ⟹   ENSRNOP00000075278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,158,362 - 25,442,709 (-)Ensembl
Rnor_6.0 Ensembl422,340,840 - 22,424,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096021   ⟹   ENSRNOP00000082870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,158,362 - 25,428,854 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100110   ⟹   ENSRNOP00000097760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,158,362 - 25,428,854 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101034   ⟹   ENSRNOP00000077516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,392,737 - 25,442,709 (-)Ensembl
RefSeq Acc Id: NM_133401   ⟹   NP_596892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,312,409 - 26,397,648 (-)NCBI
mRatBN7.2425,357,467 - 25,442,709 (-)NCBI
Rnor_6.0422,339,829 - 22,425,381 (-)NCBI
Rnor_5.0422,276,390 - 22,448,913 (-)NCBI
RGSC_v3.4421,709,855 - 21,796,628 (+)RGD
Celera420,849,575 - 20,934,573 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235994   ⟹   XP_006236056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,312,403 - 26,488,456 (-)NCBI
mRatBN7.2425,357,467 - 25,529,941 (-)NCBI
Rnor_6.0422,339,829 - 22,517,642 (-)NCBI
Rnor_5.0422,276,390 - 22,448,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285445   ⟹   XP_063141515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,312,403 - 26,396,186 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_596892   ⟸   NM_133401
- UniProtKB: Q9JK64 (UniProtKB/TrEMBL),   A0A0G2KA64 (UniProtKB/TrEMBL),   A0A9K3Y745 (UniProtKB/TrEMBL),   Q6PSM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236056   ⟸   XM_006235994
- Peptide Label: isoform X1
- UniProtKB: Q9JK64 (UniProtKB/TrEMBL),   A0A0G2KA64 (UniProtKB/TrEMBL),   A0A9K3Y745 (UniProtKB/TrEMBL),   Q6PSM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042556   ⟸   ENSRNOT00000043822
RefSeq Acc Id: ENSRNOP00000075278   ⟸   ENSRNOT00000082359
RefSeq Acc Id: ENSRNOP00000038721   ⟸   ENSRNOT00000037712
RefSeq Acc Id: ENSRNOP00000049952   ⟸   ENSRNOT00000047126
RefSeq Acc Id: ENSRNOP00000011166   ⟸   ENSRNOT00000011166
RefSeq Acc Id: ENSRNOP00000097760   ⟸   ENSRNOT00000100110
RefSeq Acc Id: ENSRNOP00000077516   ⟸   ENSRNOT00000101034
RefSeq Acc Id: ENSRNOP00000082870   ⟸   ENSRNOT00000096021
RefSeq Acc Id: XP_063141515   ⟸   XM_063285445
- Peptide Label: isoform X2
Protein Domains
ABC transmembrane type-1   ABC transporter

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692828
Promoter ID:EPDNEW_R3353
Type:initiation region
Name:Abcb1b_1
Description:ATP-binding cassette, subfamily B (MDR/TAP), member 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3352  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0422,425,436 - 22,425,496EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619951 AgrOrtholog
BioCyc Gene G2FUF-45825 BioCyc
Ensembl Genes ENSRNOG00000008012 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011166.6 UniProtKB/TrEMBL
  ENSRNOT00000082359 ENTREZGENE
  ENSRNOT00000082359.2 UniProtKB/TrEMBL
  ENSRNOT00000096021.1 UniProtKB/TrEMBL
  ENSRNOT00000100110.1 UniProtKB/TrEMBL
  ENSRNOT00000101034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABC_transptrTM_dom_typ1 UniProtKB/TrEMBL
  ATPase_AAA+_core UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/TrEMBL
KEGG Report rno:170913 UniProtKB/TrEMBL
NCBI Gene 170913 ENTREZGENE
PANTHER ABC TRANSPORTER B FAMILY UniProtKB/TrEMBL
  ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/TrEMBL
  MYCOBACTIN IMPORT ATP-BINDING/PERMEASE PROTEIN IRTB UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PharmGKB ABCB1 RGD
PhenoGen Abcb1a PhenoGen
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008012 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP ABC_TM_1 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2KA64 ENTREZGENE
  A0A8I5Y6F1_RAT UniProtKB/TrEMBL
  A0A8I5ZY39_RAT UniProtKB/TrEMBL
  A0A8I6GMN6_RAT UniProtKB/TrEMBL
  A0A9K3Y745 ENTREZGENE, UniProtKB/TrEMBL
  F7FKA8_RAT UniProtKB/TrEMBL
  Q6PSM0 ENTREZGENE, UniProtKB/TrEMBL
  Q9JK64 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2KA64 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-27 Abcb1a  ATP binding cassette subfamily B member 1A  Abcb1  ATP binding cassette subfamily B member 1  Name and Symbol changed 629549 APPROVED
2016-02-25 Abcb1  ATP binding cassette subfamily B member 1  Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-12-13 Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A  Abcb1A  ATP-binding cassette, subfamily B (MDR/TAP), member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcb1A  ATP-binding cassette, subfamily B (MDR/TAP), member 1A  Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-08-06 Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A  Abcb1  ATP-binding cassette, sub-family B (MDR/TAP), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Abcb1  ATP-binding cassette, sub-family B (MDR/TAP), member 1  Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abcb1a  ATP-binding cassette, sub-family B (MDR/TAP), member 1A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mouse homolog Abcb1a/Mdr1a is activated in hepatocellular carcinomas  
gene_expression increased expression in hepatocellular carcinomas (HCCs) and during liver regeneration 632266