Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:8871
Term: risperidone
Definition: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Chemical ID: MESH:D018967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases exportEXP 6480464CTDABCB1A protein results in increased export of RisperidonePMID:16118767
Abcb1amultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]PMID:16118767
Abcb1aaffects abundanceISOABCB1 (Homo sapiens)6480464CTDABCB1 gene polymorphism affects the abundance of Risperidone; ABCB1 protein affects the abundance of RisperidonePMID:17541883 PMID:18708991 PMID:20563569 PMID:21449914 PMID:22623266
Abcb1aaffects response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein affects the susceptibility to RisperidonePMID:15502009
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 gene polymorphism affects the susceptibility to Risperidone; ABCB1 protein affects the susceptibility to RisperidonePMID:17054409
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDRisperidone results in decreased activity of ABCB1 proteinPMID:16810505 PMID:16936711
Abcb1aincreases exportISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in increased export of RisperidonePMID:16118767
Abcb1aincreases response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased susceptibility to RisperidonePMID:19997080
Abcb1aincreases transportISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in increased transport of RisperidonePMID:22691713
Abcb1aincreases transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased transport of RisperidonePMID:22691713
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDRisperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]PMID:16936711
Go Back to source page   Continue to Ontology report