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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:83807
Term: paliperidone palmitate
Definition: A racemate comprising equimolar amounts of (R)- and (S)-paliperidone palmitate. A long-acting injectable formulation of paliperidone (the major active metabolite of risperidone) that is used for treatment of schizophrenia.
Chemical ID: MESH:D000068882
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases exportEXP 6480464CTDABCB1A protein results in increased export of Paliperidone Palmitate

PMID:16118767
Abcb1amultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]

PMID:16118767
Abcb1aaffects abundanceISORGD:7308236480464CTDABCB1 gene polymorphism affects the abundance of Paliperidone Palmitate ABCB1 protein affects the abundance of Paliperidone Palmitate

PMID:17541883
Abcb1aaffects response to substanceISORGD:16208906480464CTDABCB1A protein affects the susceptibility to Paliperidone Palmitate

PMID:15502009
Abcb1adecreases activityISORGD:7308236480464CTDPaliperidone Palmitate results in decreased activity of ABCB1 protein

PMID:16810505 PMID:16936711
Abcb1aincreases exportISORGD:16208906480464CTDABCB1A protein results in increased export of Paliperidone Palmitate

PMID:16118767
Abcb1aincreases transportISORGD:16208906480464CTDABCB1A protein results in increased transport of Paliperidone Palmitate

PMID:22691713
Abcb1aincreases transportISORGD:7308236480464CTDABCB1 protein results in increased transport of Paliperidone Palmitate

PMID:22691713
Abcb1amultiple interactionsISORGD:7308236480464CTDPaliperidone Palmitate inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]

PMID:16936711
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