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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1amultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Epirubicin] results in increased expression of ABCB1 proteinPMID:11818250
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDEpirubicin analog results in increased expression of ABCB1 mRNA; Epirubicin results in increased expression of ABCB1 mRNAPMID:22914566 PMID:23867903 PMID:26335193
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of ABCB1 mRNA; [Epirubicin co-treated with chrysophsin] results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]PMID:12576456 PMID:22914566 PMID:23867903 PMID:26335193
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