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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTDFlutamide results in increased expression of ABCB1 mRNAPMID:24136188
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDFlutamide results in increased expression of ABCB1 proteinPMID:20041327
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[Flutamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Flutamide results in increased expression of and results in increased activity of ABCB1 protein]PMID:20041327
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