GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | multiple interactions | EXP | | 6480464 | CTD | [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Cadmium]; valspodar inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride] | PMID:10636889 PMID:21436125 | Abcb1a | affects activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | valspodar affects the activity of ABCB1 protein | PMID:15788683 | Abcb1a | decreases activity | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | valspodar results in decreased activity of ABCB1A protein | PMID:10562306 PMID:17134887 | Abcb1a | decreases activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | valspodar results in decreased activity of ABCB1 protein | PMID:10997946 PMID:11934808 PMID:16810505 PMID:25015657 | Abcb1a | multiple interactions | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | valspodar results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes] | PMID:20513441 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; [valspodar results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; valspodar inhibits the reaction [[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to N-caproylsphingosine]; valspodar inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Paraquat]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Dexamethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Hydrocortisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Carvedilol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride] | PMID:10997946 PMID:16221533 PMID:16223781 PMID:16671962 PMID:17947497 PMID:18673531 PMID:21436125 PMID:21721528 PMID:22464980 PMID:25015657 PMID:25466967 PMID:29174985 PMID:30790579 PMID:9815696 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |