GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | increases expression | EXP | | 6480464 | CTD | Diazinon results in increased expression of ABCB1 mRNA; Diazinon results in increased expression of ABCB1 protein | PMID:16221533 | Abcb1a | decreases activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Diazinon results in decreased activity of ABCB1 protein | PMID:21783720 | Abcb1a | decreases response to substance | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Diazinon | PMID:21127835 | Abcb1a | increases activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Diazinon results in increased activity of ABCB1 protein | PMID:16221533 | Abcb1a | increases export | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 protein results in increased export of Diazinon | PMID:16221533 | Abcb1a | increases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Diazinon results in increased expression of ABCB1 protein | PMID:16221533 PMID:21127835 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; Deoxyglucose inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Endosulfan results in decreased activity of ABCB1 protein]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone results in decreased activity of ABCB1 protein]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole results in decreased activity of ABCB1 protein]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Sodium Azide inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Diazinon] | PMID:16221533 PMID:21783720 | | ||||||||||||||||||||||
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