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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:9159
Term: sinensetin
Definition: A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.
Chemical ID: MESH:C059295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityISORGD:7308236480464CTDsinensetin analog results in decreased activity of ABCB1 protein, sinensetin results in decreased activity of ABCB1 protein

PMID:30790579
Abcb1amultiple interactionsISORGD:7308236480464CTDsinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin], sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

PMID:30790579
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.