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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionEXP 6480464CTDVancomycin results in decreased expression of ABCB1A mRNA; Vancomycin results in decreased expression of ABCB1A proteinPMID:29964132
Abcb1amultiple interactionsEXP 6480464CTDJBP 485 inhibits the reaction [Vancomycin results in decreased expression of ABCB1A mRNA]; JBP 485 inhibits the reaction [Vancomycin results in decreased expression of ABCB1A protein]PMID:29964132
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDVancomycin results in increased expression of ABCB1A mRNAPMID:18930951
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTD[Vancomycin co-treated with Imipenem] results in decreased expression of ABCB1A mRNA; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCB1A mRNAPMID:24657338 PMID:36464106
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDCilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Vancomycin results in decreased expression of and affects the localization of ABCB1 proteinPMID:28549670
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