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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTDGenistein results in increased expression of ABCB1A mRNAPMID:32185415
Abcb1amultiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]; NR1I2 protein affects the reaction [Genistein results in increased expression of ABCB1A mRNA]; sulforaphane inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]PMID:32185415
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDGenistein results in decreased expression of ABCB1 proteinPMID:34217736
Abcb1aincreases activityISOABCB1 (Homo sapiens)6480464CTDGenistein results in increased activity of ABCB1 proteinPMID:34217736
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDGenistein results in increased expression of ABCB1 mRNA; Genistein results in increased expression of ABCB1 proteinPMID:18634814 PMID:24685904
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [Genistein results in increased expression of ABCB1 protein]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Genistein promotes the reaction [Quercetin results in increased activity of ABCB1 protein]; Genistein results in increased expression of and results in increased activity of ABCB1 proteinPMID:24685904 PMID:34217736
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