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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:6146
Term: kuwanone G
Definition: A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity.
Chemical ID: MESH:C095194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionISORGD:16208906480464CTDkuwanon G results in increased expression of ABCB1 mRNA, kuwanon G results in increased expression of ABCB1 protein

PMID:29355567
Abcb1amultiple interactionsISORGD:16208906480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]

PMID:29355567
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.