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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:80830
Term: Germacrone
Definition: A germacrane sesquiterpenoid that has formula C15H22O.
Chemical ID: MESH:C048393
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1amultiple interactionsISORGD:7308236480464CTDABCB1 protein inhibits the reaction [germacrone results in increased susceptibility to Doxorubicin], germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA], germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]

PMID:29655913
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.