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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:61080
Term: romidepsin
Definition: A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.
Chemical ID: MESH:C087123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in decreased susceptibility to romidepsinPMID:16049968
Abcb1aincreases acetylationISOABCB1 (Homo sapiens)6480464CTDromidepsin results in increased acetylation of ABCB1 promoterPMID:16223781
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDromidepsin results in increased expression of ABCB1 mRNA; romidepsin results in increased expression of ABCB1 proteinPMID:15634944 PMID:15833893 PMID:16223781
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin; [Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 protein; ABCB1 protein binds to and affects the export of romidepsin; romidepsin promotes the reaction [Tretinoin results in increased expression of ABCB1 mRNA]; Tretinoin promotes the reaction [romidepsin results in increased acetylation of ABCB1 promoter]; valspodar inhibits the reaction [[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin]PMID:15634944 PMID:16223781
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