ONTOLOGY REPORT - ANNOTATIONS
Term: somatic stem cell population maintenance
Accession: GO:0035019
browse the term
Definition: Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
Synonyms: xref: Reactome:R-HSA-452723 "Transcriptional regulation of pluripotent stem cells"
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Apc
APC, WNT signaling pathway regulator
acts_upstream_of_or_within
IGI IMP
(PMID:1541640) (PMID:18725524)
MGI
PMID:1541640 PMID:18725524
NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605
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Ascl2
achaete-scute family bHLH transcription factor 2
acts_upstream_of_or_within
IMP
(PMID:19269367)
MGI
PMID:19269367
NCBI chr 7:142,520,559...142,523,001
Ensembl chr 7:142,520,566...142,523,001
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Bcl9
B cell CLL/lymphoma 9
acts_upstream_of_or_within
IGI
(PMID:20682801)
MGI
PMID:20682801
NCBI chr 3:97,110,974...97,205,718
Ensembl chr 3:97,110,978...97,205,233
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Bcl9l
B cell CLL/lymphoma 9-like
acts_upstream_of_or_within
IGI
(PMID:20682801)
MGI
PMID:20682801
NCBI chr 9:44,394,103...44,423,203
Ensembl chr 9:44,394,122...44,423,193
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Bmpr1a
bone morphogenetic protein receptor, type 1A
acts_upstream_of_or_within
IMP
(PMID:17699604)
MGI
PMID:17699604
NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298
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Braf
Braf transforming gene
acts_upstream_of_or_within
IGI
(PMID:23022482)
MGI
PMID:23022482
NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
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Cdkn2a
cyclin dependent kinase inhibitor 2A
acts_upstream_of_or_within
IGI
(PMID:18957199)
MGI
PMID:18957199
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
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Cdx2
caudal type homeobox 2
acts_upstream_of_or_within
IMP
(PMID:20404091) (PMID:16325584)
MGI
PMID:16325584 PMID:20404091
NCBI chr 5:147,237,710...147,244,059
Ensembl chr 5:147,237,615...147,244,080
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Cul4a
cullin 4A
acts_upstream_of_or_within
IMP
(PMID:17616641)
MGI
PMID:17616641
NCBI chr 8:13,155,623...13,197,940
Ensembl chr 8:13,155,621...13,197,940
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Elf5
E74-like factor 5
acts_upstream_of_or_within
IMP
(PMID:24859262)
MGI
PMID:24859262
NCBI chr 2:103,242,443...103,281,334
Ensembl chr 2:103,242,033...103,281,334
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Erdr1x
erythroid differentiation regulator 1 x
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr X:168,793,522...168,801,793 NCBI chr Y:90,796,711...90,827,734
Ensembl chr Y:90,796,007...90,833,677
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Esrrb
estrogen related receptor, beta
acts_upstream_of_or_within
IMP
(PMID:16518401), (PMID:16767105), (PMID:20720539)
MGI
PMID:16518401 PMID:16767105 PMID:20720539
NCBI chr12:86,407,891...86,568,402
Ensembl chr12:86,407,891...86,568,402
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Fgf10
fibroblast growth factor 10
acts_upstream_of_or_within
IMP
(PMID:11880361)
MGI
PMID:11880361
NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651
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Fgf4
fibroblast growth factor 4
acts_upstream_of_or_within
IGI
(PMID:15328412)
MGI
PMID:15328412
NCBI chr 7:144,415,123...144,418,982
Ensembl chr 7:144,401,104...144,418,980
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Fgfr3
fibroblast growth factor receptor 3
acts_upstream_of_or_within
IMP
(PMID:19407216)
MGI
PMID:19407216
NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412
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Gata2
GATA binding protein 2
acts_upstream_of_or_within
IMP
(PMID:16082385)
MGI
PMID:16082385
NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014
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Gsdma3
gasdermin A3
acts_upstream_of_or_within
IMP
(PMID:22155111)
MGI
PMID:22155111
NCBI chr11:98,517,175...98,529,627
Ensembl chr11:98,517,186...98,529,052
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Hes1
hes family bHLH transcription factor 1
acts_upstream_of_or_within
IMP
(PMID:10615124)
MGI
PMID:10615124
NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614
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Hmga2
high mobility group AT-hook 2
acts_upstream_of_or_within
IMP IGI
(PMID:18957199)
MGI
PMID:18957199
NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374
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Kat6a
K(lysine) acetyltransferase 6A
acts_upstream_of_or_within
IMP
(PMID:16702405) (PMID:16651658)
MGI
PMID:16651658 PMID:16702405
NCBI chr 8:23,349,458...23,433,275
Ensembl chr 8:23,349,551...23,433,275
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Kit
KIT proto-oncogene receptor tyrosine kinase
involved_in
ISO IEA
neural stem cells from the ciliary epithelium of the eye
RGD Ensembl GO_Central
PMID:15302600
GO_REF:0000096 GO_REF:0000107 RGD:2292509
NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
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Klf10
Kruppel-like transcription factor 10
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
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Klf4
Kruppel-like transcription factor 4 (gut)
acts_upstream_of_or_within
IDA
(PMID:15358627)
MGI
PMID:15358627
NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466
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Ldb1
LIM domain binding 1
acts_upstream_of_or_within
IGI
(PMID:17991461)
MGI
PMID:17991461
NCBI chr19:46,019,963...46,036,584
Ensembl chr19:46,020,009...46,033,653
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Ldb2
LIM domain binding 2
acts_upstream_of_or_within
IGI
(PMID:17991461)
MGI
PMID:17991461
NCBI chr 5:44,593,292...44,957,466
Ensembl chr 5:44,629,474...44,957,022
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Lif
leukemia inhibitory factor
acts_upstream_of_or_within
IDA IGI
(PMID:15358627)
MGI
PMID:15358627
NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
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Lig4
ligase IV, DNA, ATP-dependent
acts_upstream_of_or_within
IMP
(PMID:17554302)
MGI
PMID:17554302
NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
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Lrp5
low density lipoprotein receptor-related protein 5
acts_upstream_of_or_within
IMP
(PMID:19672307)
MGI
PMID:19672307
NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564
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Med10
mediator complex subunit 10
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr13:69,950,467...69,964,221
Ensembl chr13:69,950,514...69,964,223
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Med12
mediator complex subunit 12
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr X:100,317,697...100,342,540
Ensembl chr X:100,317,636...100,341,071
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Med14
mediator complex subunit 14
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr X:12,541,607...12,628,813
Ensembl chr X:12,541,608...12,628,312
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Med15
mediator complex subunit 15
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr16:17,469,072...17,540,811
Ensembl chr16:17,469,072...17,550,755
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Med17
mediator complex subunit 17
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr 9:15,171,647...15,194,576
Ensembl chr 9:15,171,647...15,191,227
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Med21
mediator complex subunit 21
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr 6:146,544,077...146,552,098
Ensembl chr 6:146,544,045...146,552,230
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Med24
mediator complex subunit 24
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr11:98,595,423...98,620,245
Ensembl chr11:98,595,417...98,620,261
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Med27
mediator complex subunit 27
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr 2:29,236,822...29,414,802
Ensembl chr 2:29,236,831...29,414,805
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Med28
mediator complex subunit 28
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr 5:45,677,571...45,686,626
Ensembl chr 5:45,677,571...45,686,618
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Med30
mediator complex subunit 30
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr15:52,575,841...52,593,827
Ensembl chr15:52,575,804...52,593,960
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Med6
mediator complex subunit 6
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr12:81,620,331...81,641,782
Ensembl chr12:81,620,331...81,641,782
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Med7
mediator complex subunit 7
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr11:46,327,742...46,333,548
Ensembl chr11:46,327,752...46,333,548
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Nanog
Nanog homeobox
involved_in acts_upstream_of_or_within
ISO IDA IMP
(PMID:18388306) (PMID:16801560) (PMID:12787504) (PMID:16767105), (PMID:20720539)
UniProt MGI
PMID:12787504 PMID:16767105 PMID:16801560 PMID:18388306 PMID:20720539
NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
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Nipbl
NIPBL cohesin loading factor
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr15:8,319,308...8,494,799
Ensembl chr15:8,320,101...8,473,947
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Nkap
NFKB activating protein
acts_upstream_of_or_within
IMP
(PMID:20610818)
MGI
PMID:20610818
NCBI chr X:36,390,416...36,414,399
Ensembl chr X:36,390,448...36,414,399
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Nodal
nodal growth differentiation factor
acts_upstream_of_or_within
IGI IMP
(PMID:15505202) (PMID:16678814)
MGI
PMID:15505202 PMID:16678814
NCBI chr10:61,253,751...61,261,117
Ensembl chr10:61,253,751...61,261,117
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Nog
noggin
involved_in
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
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Nr2e1
nuclear receptor subfamily 2, group E, member 1
acts_upstream_of_or_within
IMP
(PMID:18794344) (PMID:12527005) (PMID:14702088)
MGI
PMID:12527005 PMID:14702088 PMID:18794344
NCBI chr10:42,437,959...42,459,721
Ensembl chr10:42,437,959...42,459,628
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Panct2
pluripotency-associated noncoding transcript 2
acts_upstream_of_or_within
IMP
(PMID:22327834)
MGI
PMID:22327834
NCBI chr 1:96,798,851...96,808,959
Ensembl chr 1:96,798,851...96,835,521
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Pla2g2a
phospholipase A2, group IIA (platelets, synovial fluid)
acts_upstream_of_or_within
IGI
(PMID:1541640)
MGI
PMID:1541640
NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497
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Pou5f1
POU domain, class 5, transcription factor 1
involved_in acts_upstream_of_or_within
ISO IMP
(PMID:19409607) (PMID:9814708) (PMID:14502573), (PMID:16767105), (PMID:20720539) (PMID:18388306), (PMID:19736317)
UniProt MGI BHF-UCL
PMID:9814708 PMID:14502573 PMID:16767105 PMID:18388306 PMID:19409607 PMID:19736317 PMID:20720539 More...
NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
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Pramel7
PRAME like 7
acts_upstream_of_or_within
IDA
(PMID:21425410)
MGI
PMID:21425410
NCBI chr 2:87,319,432...87,322,762
Ensembl chr 2:87,319,431...87,327,437
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Prdm16
PR domain containing 16
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330
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Raf1
v-raf-leukemia viral oncogene 1
acts_upstream_of_or_within
IGI
(PMID:23022482)
MGI
PMID:23022482
NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
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Rbpj
recombination signal binding protein for immunoglobulin kappa J region
acts_upstream_of_or_within
IMP
(PMID:21402740)
MGI
PMID:21402740
NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704
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Rest
RE1-silencing transcription factor
involved_in
IMP
(PMID:27819263)
UniProt
PMID:27819263
NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279
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Rif1
replication timing regulatory factor 1
acts_upstream_of_or_within
IMP
(PMID:16518401)
MGI
PMID:16518401
NCBI chr 2:51,962,725...52,016,781
Ensembl chr 2:51,962,844...52,012,395
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Sall4
spalt like transcription factor 4
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr 2:168,590,252...168,609,121
Ensembl chr 2:168,590,252...168,609,863
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Sfrp1
secreted frizzled-related protein 1
acts_upstream_of_or_within
IMP
(PMID:19664990)
MGI
PMID:19664990
NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648
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Ski
ski sarcoma viral oncogene homolog (avian)
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr 4:155,238,532...155,307,536
Ensembl chr 4:155,238,532...155,307,049
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Smc1a
structural maintenance of chromosomes 1A
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr X:150,799,386...150,844,969
Ensembl chr X:150,799,424...150,845,690
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Sox2
SRY (sex determining region Y)-box 2
acts_upstream_of_or_within involved_in
IMP ISO IEA
(PMID:16767105), (PMID:20720539)
MGI GO_Central Ensembl
PMID:16767105 PMID:20720539
GO_REF:0000107 GO_REF:0000119
NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610
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Sox4
SRY (sex determining region Y)-box 4
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696
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Sox9
SRY (sex determining region Y)-box 9
acts_upstream_of_or_within
IMP
(PMID:20871603)
MGI
PMID:20871603
NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
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Spi1
Spi-1 proto-oncogene
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101
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Stat3
signal transducer and activator of transcription 3
acts_upstream_of_or_within
IMP
(PMID:20720539)
MGI
PMID:20720539
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Tbx1
T-box 1
involved_in
IMP
(PMID:22495305)
UniProt
PMID:22495305
NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421
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Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
acts_upstream_of_or_within
IGI
(PMID:19718027)
MGI
PMID:19718027
NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237
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Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
acts_upstream_of_or_within
IGI IMP
(PMID:19718027) (PMID:10027409), (PMID:19251639), (PMID:9697701)
MGI
PMID:9697701 PMID:10027409 PMID:19251639 PMID:19718027
NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086
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Tcl1
T cell lymphoma breakpoint 1
acts_upstream_of_or_within
IMP
(PMID:16767105)
MGI
PMID:16767105
NCBI chr12:105,183,012...105,188,996
Ensembl chr12:105,183,009...105,189,052
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Tfap2c
transcription factor AP-2, gamma
acts_upstream_of_or_within
IMP
(PMID:20404091)
MGI
PMID:20404091
NCBI chr 2:172,387,599...172,400,542
Ensembl chr 2:172,391,513...172,400,542
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Vangl2
VANGL planar cell polarity 2
acts_upstream_of_or_within
IMP
(PMID:19497282)
MGI
PMID:19497282
NCBI chr 1:171,828,527...171,856,532
Ensembl chr 1:171,828,527...171,856,011
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Vps72
vacuolar protein sorting 72
acts_upstream_of_or_within
IDA
(PMID:19379700)
MGI
PMID:19379700
NCBI chr 3:95,018,353...95,030,362
Ensembl chr 3:95,018,333...95,030,362
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Wnt7a
wingless-type MMTV integration site family, member 7A
acts_upstream_of_or_within
IMP
(PMID:19497282)
MGI
PMID:19497282
NCBI chr 6:91,340,963...91,388,335
Ensembl chr 6:91,340,963...91,388,345
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Yap1
yes-associated protein 1
acts_upstream_of_or_within
IDA
(PMID:17980593)
MGI
PMID:17980593
NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
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Zfp36l2
zinc finger protein 36, C3H type-like 2
involved_in
IMP
(PMID:23748442)
UniProt
PMID:23748442
NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375
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Zhx2
zinc fingers and homeoboxes 2
acts_upstream_of_or_within
IDA
(PMID:19515908)
MGI
PMID:19515908
NCBI chr15:57,558,063...57,703,228
Ensembl chr15:57,558,061...57,703,228
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Sall1
spalt like transcription factor 1
acts_upstream_of_or_within
IMP
(PMID:24550112)
MGI
PMID:24550112
NCBI chr 8:89,753,867...89,770,790
Ensembl chr 8:89,753,863...89,770,790
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Six2
sine oculis-related homeobox 2
involved_in
IDA IMP
(PMID:22902740), (PMID:24598167) (PMID:18682239), (PMID:21350016)
UniProt
PMID:18682239 PMID:21350016 PMID:22902740 PMID:24598167
NCBI chr17:85,970,276...85,995,682
Ensembl chr17:85,991,705...85,995,702
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Wnt9b
wingless-type MMTV integration site family, member 9B
acts_upstream_of_or_within
IMP
(PMID:21350016)
MGI
PMID:21350016
NCBI chr11:103,618,188...103,666,098
Ensembl chr11:103,618,190...103,640,647
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Hnf1b
HNF1 homeobox B
acts_upstream_of_or_within
IMP
(PMID:20040500)
MGI
PMID:20040500
NCBI chr11:83,741,035...83,796,743
Ensembl chr11:83,740,889...83,796,645
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Pax2
paired box 2
involved_in
IMP
(PMID:17314325)
UniProt
PMID:17314325
NCBI chr19:44,735,040...44,826,708
Ensembl chr19:44,735,057...44,826,310
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Pax8
paired box 8
involved_in
IMP
(PMID:17314325)
UniProt
PMID:17314325
NCBI chr 2:24,310,563...24,365,611
Ensembl chr 2:24,310,572...24,365,611
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Bmp7
bone morphogenetic protein 7
acts_upstream_of_or_within
IMP
(PMID:9056639)
MGI
PMID:9056639
NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114
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Mir145a
microRNA 145a
involved_in
ISO
(PMID:19409607)
BHF-UCL
PMID:19409607
NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965
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Lbh
limb-bud and heart
involved_in
IMP
(PMID:25655704)
CAFA
PMID:25655704
NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942
G
Trp63
transformation related protein 63
involved_in
IMP
(PMID:25655704)
CAFA
PMID:25655704
NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852
G
Myc
myelocytomatosis oncogene
involved_in
IDA
(PMID:31005419)
UniProt
PMID:31005419
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
G
Smo
smoothened, frizzled class receptor
acts_upstream_of_or_within
IMP
(PMID:17199044)
MGI
PMID:17199044
NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364
G
Taf5l
TATA-box binding protein associated factor 5 like
involved_in
IDA
(PMID:31005419)
UniProt
PMID:31005419
NCBI chr 8:124,723,049...124,748,136
Ensembl chr 8:124,723,057...124,748,136
G
Taf6l
TATA-box binding protein associated factor 6 like
involved_in
IDA
(PMID:31005419)
UniProt
PMID:31005419
NCBI chr19:8,751,718...8,763,781
Ensembl chr19:8,751,851...8,763,781
G
Tal1
T cell acute lymphocytic leukemia 1
acts_upstream_of_or_within
IMP
(PMID:19850742)
MGI
PMID:19850742
NCBI chr 4:114,913,623...114,928,952
Ensembl chr 4:114,913,623...114,928,952
G
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
acts_upstream_of_or_within
IMP
(PMID:18467660)
MGI
PMID:18467660
NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all