Lrp5 (low density lipoprotein receptor-related protein 5) - Rat Genome Database

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Gene: Lrp5 (low density lipoprotein receptor-related protein 5) Mus musculus
Analyze
Symbol: Lrp5
Name: low density lipoprotein receptor-related protein 5
RGD ID: 1319618
MGI Page MGI
Description: Enables Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of osteoblast differentiation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5); PARTICIPATES IN Wnt signaling, canonical pathway; altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BMND1; HBM; KIAA4142; L; low-density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 7; LR3; LRP-5; LRP-7; LRP7; mKIAA4142; OPPG
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (EXP)
chlordecone  (EXP)
chlorohydrocarbon  (ISO)
chromium(3+) trichloride  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
dicrotophos  (ISO)
dioscin  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
flavonoids  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
lovastatin  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
p-toluidine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IBA,ISO)
anatomical structure regression  (IMP)
anterior/posterior pattern specification  (IBA,IGI)
apoptotic process involved in blood vessel morphogenesis  (IMP)
bone development  (IMP)
bone marrow development  (IBA,ISO)
bone morphogenesis  (IBA,ISO)
bone remodeling  (IBA,IGI,IMP)
branching involved in mammary gland duct morphogenesis  (IBA,IMP)
canonical Wnt signaling pathway  (IDA,IGI,IMP,ISO)
cell migration involved in gastrulation  (IGI)
cell-cell signaling involved in mammary gland development  (IMP)
cholesterol homeostasis  (IBA,ISO)
cholesterol metabolic process  (IMP)
embryonic digit morphogenesis  (IGI)
endocytosis  (IEA)
extracellular matrix-cell signaling  (IDA)
gastrulation with mouth forming second  (IBA,IGI)
glucose catabolic process  (ISO)
limb morphogenesis  (IGI)
mammary gland duct morphogenesis  (IGI)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
Norrin signaling pathway  (IDA,ISO)
osteoblast development  (IBA,IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (IMP)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of apoptotic process  (IMP)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IBA,IMP)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (IGI,IMP,ISO)
retinal blood vessel morphogenesis  (IBA,IMP,ISO)
somatic stem cell population maintenance  (IMP)
vasculature development  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amnion morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal b-wave shape  (IAGP)
abnormal blood-retinal barrier function  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal descending aorta morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal femur morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal germ layer development  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retinal blood vessel morphology  (IAGP)
abnormal retinal layer morphology  (IEA)
abnormal retinal nerve fiber layer morphology  (IEA)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal retinal outer nuclear layer morphology  (IEA)
abnormal retinal outer plexiform layer morphology  (IEA)
abnormal retinal pigment epithelium morphology  (IEA)
abnormal retinal vasculature morphology  (IAGP)
abnormal serotonin level  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular plexus formation  (IAGP)
abnormal vision  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent carpal bone  (IAGP)
absent endoderm  (IAGP)
absent fibula  (IAGP)
absent metacarpal bones  (IAGP)
absent somites  (IAGP)
blood vessel congestion  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased apoptosis  (IAGP)
decreased areal bone mineral density  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased bone resorption  (IAGP)
decreased bone stiffness  (IAGP)
decreased bone strength  (IAGP)
decreased bone volume  (IAGP)
decreased circulating insulin level  (IAGP)
decreased compact bone mass  (IAGP)
decreased diameter of femur  (IAGP)
decreased diameter of tibia  (IAGP)
decreased fetal size  (IAGP)
decreased insulin secretion  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoblast proliferation  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased serotonin level  (IAGP)
decreased total retina thickness  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
disorganized retinal inner nuclear layer  (IEA)
disorganized retinal outer nuclear layer  (IEA)
disorganized retinal outer plexiform layer  (IEA)
ectopic cartilage  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
failure of bone ossification  (IAGP)
fragile skeleton  (IAGP)
gliosis  (IEA)
hypoactivity  (IEA)
impaired glucose tolerance  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased bone ossification  (IAGP)
increased bone stiffness  (IAGP)
increased bone strength  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased cholesterol level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased compact bone mass  (IAGP)
increased compact bone thickness  (IAGP)
increased forebrain size  (IAGP)
increased serotonin level  (IAGP)
increased thigmotaxis  (IEA)
increased trabecular bone mass  (IAGP)
increased trabecular bone thickness  (IAGP)
increased vascular permeability  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
monodactyly  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
osteoporosis  (IAGP)
persistence of hyaloid vascular system  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
retinal degeneration  (IEA)
retinal ganglion cell degeneration  (IEA)
retinal photoreceptor degeneration  (IEA)
split sternum  (IAGP)
synostosis  (IAGP)
thin parietal bone  (IAGP)
thin retinal inner plexiform layer  (IEA)
thin retinal outer nuclear layer  (IEA)
thin retinal outer plexiform layer  (IEA)
References

References - curated
1. Caira FC, etal., J Am Coll Cardiol. 2006 Apr 18;47(8):1707-12. Epub 2006 Mar 20.
2. Cheung WM, etal., Bone. 2006 Sep;39(3):470-6. Epub 2006 May 6.
3. Cnossen WR, etal., Eur J Hum Genet. 2016 Feb;24(2):237-42. doi: 10.1038/ejhg.2015.86. Epub 2015 Apr 29.
4. Cnossen WR, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5343-8. doi: 10.1073/pnas.1309438111. Epub 2014 Mar 24.
5. Ergun SG, etal., Eur J Med Genet. 2017 Mar;60(3):200-204. doi: 10.1016/j.ejmg.2017.01.007. Epub 2017 Jan 19.
6. Gong Y, etal., Cell. 2001 Nov 16;107(4):513-23.
7. Jacobsen CM, etal., J Bone Miner Res. 2014 Oct;29(10):2297-306. doi: 10.1002/jbmr.2198.
8. Jiang Y, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):347-55. doi: 10.1177/1535370213519215. Epub 2014 Feb 7.
9. Jiao X, etal., Am J Hum Genet. 2004 Nov;75(5):878-84. Epub 2004 Sep 2.
10. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
11. Korvala J, etal., BMC Med Genet. 2012 Apr 10;13:26. doi: 10.1186/1471-2350-13-26.
12. Liu MJ, etal., J Tradit Chin Med. 2011 Jun;31(2):98-102.
13. Lui PP, etal., Rheumatology (Oxford). 2013 Sep;52(9):1609-18. doi: 10.1093/rheumatology/ket214. Epub 2013 Jun 17.
14. MGD data from the GO Consortium
15. MGD IEA
16. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
17. Niziolek PJ, etal., PLoS One. 2015 Nov 10;10(11):e0140775. doi: 10.1371/journal.pone.0140775. eCollection 2015.
18. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. OMIM Disease Annotation Pipeline
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated import pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Sun L, etal., J Spinal Cord Med. 2013 Nov;36(6):616-22. doi: 10.1179/2045772312Y.0000000020. Epub 2013 Feb 20.
26. Urano T, etal., Spine (Phila Pa 1976). 2007 Jan 1;32(1):25-9.
27. Wang Z, etal., Mol Cell Biol. 2005 Jun;25(12):5022-30.
28. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
29. Zhou J, etal., Arch Med Res. 2012 May;43(4):274-82. doi: 10.1016/j.arcmed.2012.06.002. Epub 2012 Jun 13.
Additional References at PubMed
PMID:9714764   PMID:10049586   PMID:10349636   PMID:11029008   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11336703   PMID:11956231   PMID:12412008   PMID:12477932   PMID:12509421  
PMID:12509515   PMID:12579474   PMID:12581525   PMID:12817748   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15035989   PMID:15064719   PMID:15142971   PMID:15143170   PMID:15207752  
PMID:15342465   PMID:15489334   PMID:15537447   PMID:15699046   PMID:15800025   PMID:16141072   PMID:16141073   PMID:16163358   PMID:16293698   PMID:16378759   PMID:16613987   PMID:16790443  
PMID:16973609   PMID:17002572   PMID:17064353   PMID:17147489   PMID:17229572   PMID:17335347   PMID:17543594   PMID:17627087   PMID:17700537   PMID:17785445   PMID:17953485   PMID:17967808  
PMID:18039971   PMID:18044981   PMID:18089564   PMID:18263894   PMID:18287559   PMID:18351675   PMID:18502762   PMID:18524778   PMID:18566875   PMID:18632848   PMID:18635608   PMID:18698360  
PMID:18723514   PMID:18800919   PMID:18927151   PMID:18957220   PMID:19023080   PMID:19041748   PMID:19056682   PMID:19075000   PMID:19154719   PMID:19158955   PMID:19503830   PMID:19515997  
PMID:19562671   PMID:19672307   PMID:19795382   PMID:19795519   PMID:19837032   PMID:19837033   PMID:19906978   PMID:20042609   PMID:20063381   PMID:20160075   PMID:20333369   PMID:20340138  
PMID:20359476   PMID:20392224   PMID:20652025   PMID:20724449   PMID:20847738   PMID:21140374   PMID:21185284   PMID:21267068   PMID:21337463   PMID:21402791   PMID:21419885   PMID:21602802  
PMID:21608033   PMID:21623369   PMID:21678468   PMID:21731673   PMID:21855668   PMID:21866564   PMID:21873635   PMID:21887268   PMID:21905163   PMID:21924256   PMID:21969016   PMID:22272305  
PMID:22303459   PMID:22337886   PMID:22359381   PMID:22433869   PMID:22567110   PMID:22576936   PMID:22750014   PMID:22848540   PMID:22850184   PMID:22945629   PMID:23293290   PMID:23356985  
PMID:23553928   PMID:23675479   PMID:23841513   PMID:23901037   PMID:23925701   PMID:23945236   PMID:24006258   PMID:24058663   PMID:24140542   PMID:24191021   PMID:24225945   PMID:24479426  
PMID:24639464   PMID:24692544   PMID:24700412   PMID:24742230   PMID:24789067   PMID:24859004   PMID:24921217   PMID:24952961   PMID:25009587   PMID:25061805   PMID:25083995   PMID:25375916  
PMID:25562323   PMID:25640331   PMID:25656427   PMID:25710911   PMID:25727890   PMID:25748163   PMID:25802278   PMID:25808845   PMID:25902418   PMID:26091161   PMID:26273529   PMID:26288816  
PMID:26443636   PMID:26681532   PMID:26711269   PMID:26739212   PMID:26772978   PMID:26891291   PMID:27031698   PMID:27045006   PMID:27083399   PMID:27230741   PMID:27297606   PMID:27524797  
PMID:27668462   PMID:27802170   PMID:27803037   PMID:27864382   PMID:28158288   PMID:28240364   PMID:28356706   PMID:28425175   PMID:28607813   PMID:28938444   PMID:29031500   PMID:29123193  
PMID:29176883   PMID:29454962   PMID:29602775   PMID:29899194   PMID:30172741   PMID:30254141   PMID:30325689   PMID:30332639   PMID:30404864   PMID:30409757   PMID:30664649   PMID:30668923  
PMID:30713111   PMID:30902975   PMID:31138536   PMID:31220102   PMID:31239337   PMID:31327495   PMID:31452509   PMID:31648079   PMID:32290105   PMID:32325033   PMID:32369449   PMID:32820125  
PMID:32822074   PMID:32917787   PMID:33164872   PMID:33197324   PMID:33326696   PMID:33436499   PMID:33619830   PMID:33831261   PMID:33905568   PMID:34172578  


Genomics

Comparative Map Data
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,298,866 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)Ensembl
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBI
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBI
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBI
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBI
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBI
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBI
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBIVero_WHO_p1.0
Lrp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Lrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,614,248 - 3,615,714UniSTSGRCm38
MGSCv37193,614,248 - 3,615,714UniSTSGRCm37
Celera193,493,571 - 3,495,039UniSTS
Cytogenetic Map19BUniSTS
cM Map19 UniSTS
AF064984  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,584,897 - 3,585,010UniSTSGRCm38
MGSCv37193,584,897 - 3,585,010UniSTSGRCm37
Celera193,457,057 - 3,457,170UniSTS
Cytogenetic Map19BUniSTS
Whitehead/MRC_RH1970.36UniSTS
D19Mit68  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,645,155 - 3,645,286UniSTSGRCm38
MGSCv37193,645,155 - 3,645,286UniSTSGRCm37
Celera193,524,467 - 3,524,593UniSTS
Cytogenetic Map19BUniSTS
cM Map196.0UniSTS
Whitehead Genetic193.3UniSTS
Whitehead/MRC_RH1968.56UniSTS
Lrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map19 UniSTS
Lrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
Lrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,593,524 - 3,593,621UniSTSGRCm38
MGSCv37193,593,524 - 3,593,621UniSTSGRCm37
Celera193,465,658 - 3,465,755UniSTS
Cytogenetic Map19BUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120278703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120645286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122321310Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19327855120562299Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5536
Count of miRNA genes:942
Interacting mature miRNAs:1381
Transcripts:ENSMUST00000025856, ENSMUST00000176867, ENSMUST00000177294, ENSMUST00000177330
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_388250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF064984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB070734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025856   ⟹   ENSMUSP00000025856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,634,828 - 3,736,556 (-)Ensembl
GRCm38.p6 Ensembl193,584,828 - 3,686,556 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176867   ⟹   ENSMUSP00000135654
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,671,671 - 3,736,564 (-)Ensembl
GRCm38.p6 Ensembl193,621,671 - 3,686,564 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177294   ⟹   ENSMUSP00000134771
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,634,836 - 3,665,792 (-)Ensembl
GRCm38.p6 Ensembl193,584,836 - 3,615,792 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177330   ⟹   ENSMUSP00000134983
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,634,831 - 3,736,561 (-)Ensembl
GRCm38.p6 Ensembl193,584,831 - 3,686,561 (-)Ensembl
RefSeq Acc Id: NM_008513   ⟹   NP_032539
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,634,825 - 3,736,564 (-)NCBI
GRCm38193,584,825 - 3,686,564 (-)ENTREZGENE
MGSCv37193,584,825 - 3,686,564 (-)RGD
Celera193,456,985 - 3,565,560 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_388250
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,655,293 - 3,736,574 (-)NCBI
GRCm38193,605,293 - 3,686,585 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032539   ⟸   NM_008513
- Peptide Label: precursor
- UniProtKB: Q91VN0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025856   ⟸   ENSMUST00000025856
RefSeq Acc Id: ENSMUSP00000134771   ⟸   ENSMUST00000177294
RefSeq Acc Id: ENSMUSP00000134983   ⟸   ENSMUST00000177330
RefSeq Acc Id: ENSMUSP00000135654   ⟸   ENSMUST00000176867
Protein Domains
EGF-like   LDL-receptor class A

Promoters
RGD ID:6830170
Promoter ID:MM_KWN:25933
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung
Transcripts:NM_008513,   UC008FWR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,686,234 - 3,686,734 (-)MPROMDB
RGD ID:13678344
Promoter ID:EPDNEW_M23321
Type:initiation region
Name:Lrp5_1
Description:Mus musculus low density lipoprotein receptor-related protein5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38193,686,561 - 3,686,621EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1278315 AgrOrtholog
Ensembl Genes ENSMUSG00000024913 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134771 UniProtKB/TrEMBL
  ENSMUSP00000134983 UniProtKB/TrEMBL
  ENSMUSP00000135654 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000176867 UniProtKB/TrEMBL
  ENSMUST00000177294 UniProtKB/TrEMBL
  ENSMUST00000177330 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRP5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16973 UniProtKB/Swiss-Prot
MGD MGI:1278315 ENTREZGENE
NCBI Gene 16973 ENTREZGENE
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp5 PhenoGen
PIRSF LDL_recpt-rel_p5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BIY3_MOUSE UniProtKB/TrEMBL
  H3BJH0_MOUSE UniProtKB/TrEMBL
  H3BL52_MOUSE UniProtKB/TrEMBL
  LRP5_MOUSE UniProtKB/Swiss-Prot
  Q3UI55_MOUSE UniProtKB/TrEMBL
  Q571K3_MOUSE UniProtKB/TrEMBL
  Q91VN0 ENTREZGENE
UniProt Secondary E9QQ75 UniProtKB/Swiss-Prot
  O88883 UniProtKB/Swiss-Prot
  Q9R208 UniProtKB/Swiss-Prot