Hnf1b (HNF1 homeobox B) - Rat Genome Database

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Gene: Hnf1b (HNF1 homeobox B) Mus musculus
Analyze
Symbol: Hnf1b
Name: HNF1 homeobox B
RGD ID: 11398
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of mesenchymal cell apoptotic process; regulation of transcription by RNA polymerase II; and tube morphogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI385728; AI987804; hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF-1-beta; HNF-1B; HNF-1Be; HNF-1Beta; Hnf1be; Hnf1beta; homeoprotein LFB3; LFB; LFB3; Tcf-2; Tcf2; transcription factor 2; vHN; vHNF1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,741,035 - 83,796,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,740,889 - 83,796,645 (+)EnsemblGRCm39 Ensembl
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBIMGSCv36mm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IMP)
apoptotic process  (IMP)
branching morphogenesis of an epithelial tube  (IMP)
circadian regulation of gene expression  (ISO)
embryonic digestive tract morphogenesis  (IMP)
embryonic morphogenesis  (ISO)
endocrine pancreas development  (ISO)
endoderm development  (IMP)
endoderm formation  (ISO)
endodermal cell fate specification  (IMP)
epithelial cell proliferation  (IMP)
epithelium development  (IMP)
genitalia development  (ISO)
hepatoblast differentiation  (IMP)
hepatocyte differentiation  (ISO)
hindbrain development  (IMP)
inner cell mass cell differentiation  (IMP)
insulin secretion  (IMP)
kidney development  (IMP,ISO)
kidney morphogenesis  (IGI)
liver development  (IMP)
mesenchymal cell apoptotic process involved in metanephros development  (IMP)
mesonephric duct development  (IMP)
mesonephric duct formation  (IMP)
mesonephric tubule development  (IGI)
negative regulation of apoptotic process  (IMP)
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis  (IMP)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA)
nephric duct development  (IMP)
nephric duct formation  (IMP)
Notch signaling pathway  (IDA)
pancreas development  (IEA)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
pronephric nephron tubule development  (ISO)
pronephros development  (ISO)
protein-DNA complex assembly  (ISO)
regulation of branch elongation involved in ureteric bud branching  (IMP)
regulation of pronephros size  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of Wnt signaling pathway  (IMP)
response to carbohydrate  (ISO)
response to glucose  (IMP)
response to organic cyclic compound  (ISO)
response to xenobiotic stimulus  (ISO)
ureteric bud elongation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile duct physiology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic endoderm formation  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal gallbladder epithelium morphology  (IAGP)
abnormal hepatobiliary system morphology  (IAGP)
abnormal hepatobiliary system physiology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal interlobular bile duct morphology  (IAGP)
abnormal intrahepatic bile duct morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal loop of Henle morphology  (IAGP)
abnormal metanephros morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal primitive endoderm morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent blastocoele  (IAGP)
absent ectoplacental cavity  (IAGP)
absent parietal endoderm  (IAGP)
absent proamniotic cavity  (IAGP)
absent visceral endoderm  (IAGP)
cachexia  (IAGP)
chronic pancreas inflammation  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating insulin level  (IAGP)
decreased embryo size  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver function  (IAGP)
decreased pancreatic acinar cell number  (IAGP)
decreased pancreatic islet number  (IAGP)
disorganized embryonic tissue  (IAGP)
disorganized extraembryonic tissue  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
enlarged liver  (IAGP)
failure to gastrulate  (IAGP)
hepatic necrosis  (IAGP)
hydronephrosis  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased fasting circulating glucose level  (IAGP)
intrahepatic cholestasis  (IAGP)
jaundice  (IAGP)
liver inflammation  (IAGP)
muscular atrophy  (IAGP)
pancreas fibrosis  (IAGP)
pancreas lipomatosis  (IAGP)
pancreatic acinar hypoplasia  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal glomerulus cyst  (IAGP)
small pancreatic islets  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Bellanne-Chantelot C, etal., Ann Intern Med. 2004 Apr 6;140(7):510-7.
2. Mutations in MODY genes are not common cause of early-onset type 2 diabetes in Mexican families. Dominguez-Lopez A, etal., JOP. 2005 May 10;6(3):238-45.
3. Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease. Edghill EL, etal., Nephrol Dial Transplant. 2008 Feb;23(2):627-35. Epub 2007 Oct 30.
4. Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage. Haumaitre C, etal., J Biol Chem. 2003 Oct 17;278(42):40933-42. Epub 2003 Jul 14.
5. Splice site mutation in the hepatocyte nuclear factor-1 beta gene, IVS2nt + 1G > A, associated with maturity-onset diabetes of the young, renal dysplasia and bicornuate uterus. Iwasaki N, etal., Diabetologia. 2001 Mar;44(3):387-8.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young. Raile K, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2658-64. Epub 2009 May 5.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. Weber S, etal., J Am Soc Nephrol. 2006 Oct;17(10):2864-70. Epub 2006 Sep 13.
Additional References at PubMed
PMID:1352161   PMID:1363228   PMID:1673925   PMID:1685890   PMID:1685988   PMID:2044952   PMID:7613042   PMID:7692743   PMID:8261111   PMID:8598044   PMID:8662231   PMID:9077551  
PMID:9119393   PMID:9398836   PMID:10331425   PMID:10349636   PMID:10518495   PMID:10518496   PMID:10559500   PMID:10866673   PMID:11042159   PMID:11076861   PMID:11403854   PMID:11456274  
PMID:11934848   PMID:11934849   PMID:12217876   PMID:12367519   PMID:12477932   PMID:12520002   PMID:12748966   PMID:14570708   PMID:14610273   PMID:14656222   PMID:14681479   PMID:15005571  
PMID:15029248   PMID:15067314   PMID:15085338   PMID:15142986   PMID:15148361   PMID:15175265   PMID:15269167   PMID:15280201   PMID:15489334   PMID:15509593   PMID:15531365   PMID:15550389  
PMID:15618518   PMID:15647252   PMID:15668393   PMID:15872003   PMID:15905556   PMID:15930087   PMID:16141072   PMID:16141073   PMID:16274963   PMID:16341222   PMID:16380477   PMID:16470614  
PMID:16472605   PMID:16880268   PMID:16912278   PMID:17021047   PMID:17093497   PMID:17185046   PMID:17241623   PMID:17251353   PMID:17476336   PMID:17580084   PMID:17609113   PMID:17662710  
PMID:17669392   PMID:17855651   PMID:17936262   PMID:17996499   PMID:18029548   PMID:18038450   PMID:18077349   PMID:18287559   PMID:18346943   PMID:18356246   PMID:18617288   PMID:18635606  
PMID:18656965   PMID:18778483   PMID:18974875   PMID:19005009   PMID:19185577   PMID:19369401   PMID:19403103   PMID:19487809   PMID:19551907   PMID:19556507   PMID:19913010   PMID:19924231  
PMID:19966811   PMID:20040500   PMID:20059953   PMID:20059954   PMID:20211142   PMID:20235219   PMID:20388655   PMID:20843830   PMID:20979532   PMID:21062863   PMID:21094155   PMID:21266405  
PMID:21267068   PMID:21385055   PMID:21525287   PMID:21731673   PMID:21784065   PMID:21786021   PMID:21829703   PMID:21873635   PMID:21888903   PMID:21898486   PMID:21940751   PMID:22178591  
PMID:22461559   PMID:22511595   PMID:22529374   PMID:22675211   PMID:22711520   PMID:22764048   PMID:23177622   PMID:23325761   PMID:23362348   PMID:23362349   PMID:23386589   PMID:23389544  
PMID:23471965   PMID:23487309   PMID:23554936   PMID:23555292   PMID:23657850   PMID:23684747   PMID:23704921   PMID:23759744   PMID:23852729   PMID:24003036   PMID:24415412   PMID:24449835  
PMID:24952961   PMID:25063451   PMID:25446530   PMID:25503683   PMID:25576928   PMID:25715394   PMID:25715395   PMID:25919081   PMID:26033091   PMID:26292219   PMID:26450967   PMID:26677864  
PMID:26689699   PMID:26771085   PMID:26856660   PMID:26887806   PMID:27107701   PMID:27358050   PMID:27582005   PMID:27591083   PMID:27615128   PMID:27820600   PMID:27993987   PMID:28193997  
PMID:28285191   PMID:28507058   PMID:28577853   PMID:28807937   PMID:28928395   PMID:29113990   PMID:29129523   PMID:29158444   PMID:29449451   PMID:29459093   PMID:29561186   PMID:29712641  
PMID:29735694   PMID:29798841   PMID:30097458   PMID:30487608   PMID:30590051   PMID:31006513   PMID:31229598   PMID:31308417   PMID:31323030   PMID:31524221   PMID:31712448   PMID:31875961  
PMID:32886109   PMID:33113370   PMID:33453998   PMID:33527355   PMID:33737325   PMID:34433966   PMID:34653285   PMID:35554666   PMID:35729116  


Genomics

Comparative Map Data
Hnf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,741,035 - 83,796,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,740,889 - 83,796,645 (+)EnsemblGRCm39 Ensembl
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBIMGSCv36mm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
HNF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381737,686,431 - 37,745,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1737,686,431 - 37,745,059 (-)EnsemblGRCh38hg38GRCh38
GRCh371736,046,434 - 36,105,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,120,547 - 33,179,209 (-)NCBINCBI36Build 36hg18NCBI36
Build 341733,162,728 - 33,179,182NCBI
Celera1732,869,487 - 32,928,989 (-)NCBICelera
Cytogenetic Map17q12ENTREZGENE
HuRef1731,984,120 - 32,042,660 (-)NCBIHuRef
CHM1_11736,077,994 - 36,136,668 (-)NCBICHM1_1
T2T-CHM13v2.01738,673,401 - 38,732,032 (-)NCBIT2T-CHM13v2.0
Hnf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21068,735,894 - 68,789,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,735,894 - 68,789,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1073,355,884 - 73,409,885 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01072,860,897 - 72,914,896 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01068,325,325 - 68,379,318 (+)NCBIRnor_WKY
Rnor_6.01071,159,863 - 71,218,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,159,869 - 71,218,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,778,492 - 70,829,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,081,091 - 72,187,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11072,095,460 - 72,201,382 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBICelera
Cytogenetic Map10q26NCBI
Hnf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955451320,283 - 371,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955451320,283 - 371,420 (+)NCBIChiLan1.0ChiLan1.0
HNF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11719,633,424 - 19,691,863 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1719,633,424 - 19,691,863 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01719,333,485 - 19,392,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HNF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,437,992 - 37,493,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,438,583 - 37,492,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha936,661,511 - 36,717,034 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,248,175 - 38,303,484 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,248,763 - 38,303,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,029,129 - 37,084,643 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,316,583 - 37,372,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,403,808 - 37,459,176 (-)NCBIUU_Cfam_GSD_1.0
Hnf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,371,915 - 36,425,499 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936490649,551 - 702,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,143,121 - 39,201,631 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,143,119 - 39,201,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21240,788,316 - 40,846,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11630,033,486 - 30,097,106 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1630,036,766 - 30,097,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666077760,378 - 820,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnf1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248714,661,669 - 4,712,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248714,662,104 - 4,713,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
AI987804  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381183,905,666 - 83,905,801UniSTSGRCm38
MGSCv371183,719,168 - 83,719,303UniSTSGRCm37
Celera1193,510,542 - 93,510,677UniSTS
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Whitehead/MRC_RH111065.61UniSTS
AI385728  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381183,905,536 - 83,905,666UniSTSGRCm38
MGSCv371183,719,038 - 83,719,168UniSTSGRCm37
Celera1193,510,412 - 93,510,542UniSTS
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Whitehead/MRC_RH111068.85UniSTS
Hnf1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Tcf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Tcf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381183,856,001 - 83,856,099UniSTSGRCm38
MGSCv371183,669,503 - 83,669,601UniSTSGRCm37
Celera1193,460,305 - 93,460,403UniSTS
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Tcf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Tcf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381183,861,757 - 83,861,949UniSTSGRCm38
MGSCv371183,675,259 - 83,675,451UniSTSGRCm37
Celera1193,466,484 - 93,466,676UniSTS
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Tcf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381183,850,484 - 83,850,956UniSTSGRCm38
MGSCv371183,663,986 - 83,664,458UniSTSGRCm37
Celera1193,454,788 - 93,455,260UniSTS
Cytogenetic Map11CUniSTS
cM Map1144.0UniSTS
Hnf1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1567
Count of miRNA genes:511
Interacting mature miRNAs:641
Transcripts:ENSMUST00000021016, ENSMUST00000108113, ENSMUST00000108114, ENSMUST00000135975, ENSMUST00000146786
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB052659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV140806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY902343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021016   ⟹   ENSMUSP00000021016
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,741,681 - 83,796,645 (+)Ensembl
GRCm38.p6 Ensembl1183,850,855 - 83,905,819 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108113   ⟹   ENSMUSP00000103748
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,743,786 - 83,796,645 (+)Ensembl
GRCm38.p6 Ensembl1183,852,960 - 83,905,819 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108114   ⟹   ENSMUSP00000103749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,741,700 - 83,796,642 (+)Ensembl
GRCm38.p6 Ensembl1183,850,874 - 83,905,816 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135975   ⟹   ENSMUSP00000117036
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,740,889 - 83,746,924 (+)Ensembl
GRCm38.p6 Ensembl1183,850,063 - 83,856,098 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146786   ⟹   ENSMUSP00000123297
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,743,068 - 83,755,004 (+)Ensembl
GRCm38.p6 Ensembl1183,852,242 - 83,864,178 (+)Ensembl
RefSeq Acc Id: NM_001291268   ⟹   NP_001278197
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,741,695 - 83,796,743 (+)NCBI
GRCm381183,850,869 - 83,905,917 (+)NCBI
Celera1193,455,173 - 93,510,793 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291269   ⟹   NP_001278198
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,743,786 - 83,796,743 (+)NCBI
GRCm381183,852,960 - 83,905,917 (+)NCBI
Celera1193,455,173 - 93,510,793 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009330   ⟹   NP_033356
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,741,695 - 83,796,743 (+)NCBI
GRCm381183,850,869 - 83,905,917 (+)NCBI
MGSCv371183,664,371 - 83,719,317 (+)RGD
Celera1193,455,173 - 93,510,793 (+)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532791   ⟹   XP_006532854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,741,485 - 83,796,253 (+)NCBI
GRCm381183,850,659 - 83,905,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532793   ⟹   XP_006532856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,741,485 - 83,796,253 (+)NCBI
GRCm381183,850,659 - 83,905,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532794   ⟹   XP_006532857
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,741,035 - 83,796,253 (+)NCBI
GRCm381183,850,209 - 83,905,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532796   ⟹   XP_006532859
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,743,759 - 83,796,253 (+)NCBI
GRCm381183,852,933 - 83,905,427 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033356   ⟸   NM_009330
- Peptide Label: isoform 1
- UniProtKB: Q9WTL6 (UniProtKB/Swiss-Prot),   P27889 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532857   ⟸   XM_006532794
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006532854   ⟸   XM_006532791
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006532856   ⟸   XM_006532793
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006532859   ⟸   XM_006532796
- Peptide Label: isoform X4
- UniProtKB: P27889 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278197   ⟸   NM_001291268
- Peptide Label: isoform 2
- UniProtKB: P27889 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278198   ⟸   NM_001291269
- Peptide Label: isoform 3
- UniProtKB: P27889 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103748   ⟸   ENSMUST00000108113
RefSeq Acc Id: ENSMUSP00000103749   ⟸   ENSMUST00000108114
RefSeq Acc Id: ENSMUSP00000123297   ⟸   ENSMUST00000146786
RefSeq Acc Id: ENSMUSP00000117036   ⟸   ENSMUST00000135975
RefSeq Acc Id: ENSMUSP00000021016   ⟸   ENSMUST00000021016
Protein Domains
HNF-p1   Homeobox   POU-specific atypical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27889-F1-model_v2 AlphaFold P27889 1-558 view protein structure

Promoters
RGD ID:6821070
Promoter ID:MM_KWN:8924
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000076356
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361183,662,826 - 83,663,326 (+)MPROMDB
RGD ID:6821068
Promoter ID:MM_KWN:8925
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000001941,   UC007KPY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361183,664,099 - 83,664,599 (+)MPROMDB
RGD ID:6821065
Promoter ID:MM_KWN:8927
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:ENSMUST00000108113
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361183,665,571 - 83,666,542 (+)MPROMDB
RGD ID:8675932
Promoter ID:EPDNEW_M15997
Type:multiple initiation site
Name:Hnf1b_1
Description:Mus musculus HNF1 homeobox B , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381183,850,874 - 83,850,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98505 AgrOrtholog
Ensembl Genes ENSMUSG00000020679 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021016 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103748 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103749 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117036.4 UniProtKB/TrEMBL
  ENSMUSP00000123297.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021016 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000108113 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000108114 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000135975.3 UniProtKB/TrEMBL
  ENSMUST00000146786.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HNF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1_POU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF1_dimer_N_dom_sf UniProtKB/Swiss-Prot
  HNF1b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF_P1 UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21410 UniProtKB/Swiss-Prot
MGD MGI:98505 ENTREZGENE
NCBI Gene 21410 ENTREZGENE
PANTHER PTHR11568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HNF-1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HNF1B RGD
PhenoGen Hnf1b PhenoGen
PROSITE HNF_P1 UniProtKB/Swiss-Prot
  HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100957 UniProtKB/Swiss-Prot
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47413 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQH4_MOUSE UniProtKB/TrEMBL
  F6XBL0_MOUSE UniProtKB/TrEMBL
  HNF1B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WTL6 ENTREZGENE
UniProt Secondary Q5NC37 UniProtKB/Swiss-Prot
  Q8R162 UniProtKB/Swiss-Prot
  Q9CS26 UniProtKB/Swiss-Prot
  Q9R1W1 UniProtKB/Swiss-Prot
  Q9R1W2 UniProtKB/Swiss-Prot
  Q9WTL5 UniProtKB/Swiss-Prot
  Q9WTL6 UniProtKB/Swiss-Prot