Tcf7l1 (transcription factor 7 like 1 (T cell specific, HMG box)) - Rat Genome Database

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Gene: Tcf7l1 (transcription factor 7 like 1 (T cell specific, HMG box)) Mus musculus
Analyze
Symbol: Tcf7l1
Name: transcription factor 7 like 1 (T cell specific, HMG box)
RGD ID: 1323252
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and chromatin binding activity. Acts upstream of or within several processes, including axial mesoderm morphogenesis; regulation of DNA-templated transcription; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human TCF7L1 (transcription factor 7 like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHb21; HMG box transcription factor 3; mTCF-3; T-cell factor 3; Tcf-3; Tcf3; transcription factor 3; transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 2 (T-cell specific, HMG box)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,603,354 - 72,766,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,603,361 - 72,766,237 (-)EnsemblGRCm39 Ensembl
GRCm38672,626,371 - 72,789,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,626,378 - 72,789,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,576,374 - 72,738,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,555,889 - 72,718,465 (-)NCBIMGSCv36mm8
Celera674,727,941 - 74,893,703 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal eyelid development  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal skin physiology  (IAGP)
absent hair follicles  (IAGP)
absent heart  (IAGP)
absent somites  (IAGP)
absent vibrissae  (IAGP)
anophthalmia  (IAGP)
corneal opacity  (IEA)
decreased embryo size  (IAGP)
decreased forebrain size  (IAGP)
decreased keratinocyte proliferation  (IAGP)
dilated vasculature  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged pericardium  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
failure of eyelid fusion  (IAGP)
forelimb oligodactyly  (IAGP)
hydrops fetalis  (IAGP)
increased axial mesoderm size  (IAGP)
increased somite number  (IAGP)
internal hemorrhage  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
microphthalmia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
rostral body truncation  (IAGP)
rostral-caudal axis duplication  (IAGP)
small embryonic telencephalon  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Korinek V, etal., Mol Cell Biol. 1998 Mar;18(3):1248-56.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
11. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10090727   PMID:10349636   PMID:10498690   PMID:10631168   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11404013   PMID:11445543   PMID:11731231   PMID:11731265   PMID:12477932  
PMID:12520002   PMID:14610273   PMID:14668413   PMID:14681479   PMID:15226261   PMID:15342465   PMID:15507449   PMID:15576404   PMID:15713628   PMID:15800025   PMID:15866165   PMID:15907834  
PMID:16141072   PMID:16141073   PMID:16678101   PMID:16678815   PMID:16894029   PMID:16936075   PMID:17018284   PMID:17065530   PMID:17335794   PMID:17607356   PMID:17644613   PMID:17681174  
PMID:17823311   PMID:17919533   PMID:17967808   PMID:18202148   PMID:18243104   PMID:18270576   PMID:18287559   PMID:18347094   PMID:18467660   PMID:18483421   PMID:18557763   PMID:18565209  
PMID:18593557   PMID:18635608   PMID:18772112   PMID:18799693   PMID:19303461   PMID:19449303   PMID:19515997   PMID:19591821   PMID:19718027   PMID:19741146   PMID:20059953   PMID:20359476  
PMID:20412781   PMID:20883686   PMID:20932939   PMID:21177349   PMID:21194568   PMID:21267068   PMID:21533166   PMID:21565611   PMID:21677750   PMID:21685894   PMID:21730189   PMID:21731673  
PMID:21775418   PMID:21873635   PMID:21914845   PMID:21938009   PMID:22007134   PMID:22166339   PMID:22270545   PMID:22393260   PMID:22564414   PMID:22573616   PMID:22988430   PMID:23152144  
PMID:23487311   PMID:23810553   PMID:23824573   PMID:24463605   PMID:24735878   PMID:24832538   PMID:24952961   PMID:24997151   PMID:25038042   PMID:25114215   PMID:25546423   PMID:25810530  
PMID:25885041   PMID:26675138   PMID:26764381   PMID:26930384   PMID:27302397   PMID:27414999   PMID:29513567   PMID:29513653   PMID:29751817   PMID:30326964   PMID:30332639   PMID:30886049  
PMID:30959515   PMID:30973865   PMID:31987502   PMID:32179550   PMID:32253237   PMID:32414917   PMID:32820720   PMID:33195246   PMID:33587034   PMID:34321999   PMID:34525377   PMID:35739118  
PMID:35831952   PMID:36196585   PMID:36869101   PMID:36899896   PMID:37296573  


Genomics

Comparative Map Data
Tcf7l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,603,354 - 72,766,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,603,361 - 72,766,237 (-)EnsemblGRCm39 Ensembl
GRCm38672,626,371 - 72,789,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,626,378 - 72,789,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,576,374 - 72,738,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,555,889 - 72,718,465 (-)NCBIMGSCv36mm8
Celera674,727,941 - 74,893,703 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
TCF7L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,133,392 - 85,310,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,133,392 - 85,310,387 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,360,515 - 85,537,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,214,245 - 85,391,016 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,272,391 - 85,449,162NCBI
Celera285,189,038 - 85,365,500 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,257,850 - 85,434,099 (+)NCBIHuRef
CHM1_1285,290,354 - 85,467,245 (+)NCBICHM1_1
T2T-CHM13v2.0285,135,301 - 85,312,378 (+)NCBIT2T-CHM13v2.0
Tcf7l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,238,892 - 106,404,012 (-)NCBIGRCr8
mRatBN7.24104,680,734 - 104,846,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4110,059,625 - 110,224,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,834,747 - 105,999,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,448,498 - 104,613,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,492,796 - 100,660,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,491,798 - 100,660,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,263,179 - 165,427,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,128,203 - 106,149,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14106,372,784 - 106,393,874 (-)NCBI
Celera493,833,646 - 93,998,059 (-)NCBICelera
Cytogenetic Map4q32NCBI
Tcf7l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,137,865 - 2,286,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,139,576 - 2,286,183 (-)NCBIChiLan1.0ChiLan1.0
TCF7L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21241,072,932 - 41,249,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A41,075,694 - 41,252,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,186,660 - 85,363,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,739,422 - 86,914,829 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,739,417 - 86,913,905 (+)Ensemblpanpan1.1panPan2
TCF7L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,699,958 - 39,859,167 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,699,958 - 39,858,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,371,581 - 39,530,084 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,509,531 - 40,668,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,509,321 - 40,668,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,576,919 - 39,735,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,648,692 - 39,807,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01740,048,459 - 40,208,222 (-)NCBIUU_Cfam_GSD_1.0
Tcf7l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629278,895,196 - 79,009,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,848,464 - 1,962,650 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,848,478 - 1,962,644 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1359,438,152 - 59,458,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,435,512 - 62,533,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,849,585 - 22,028,147 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604590,408,016 - 90,615,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,803,772 - 17,829,805 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,804,630 - 17,956,504 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcf7l1
5150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1852
Count of miRNA genes:686
Interacting mature miRNAs:875
Transcripts:ENSMUST00000069536, ENSMUST00000114053, ENSMUST00000141743, ENSMUST00000149446, ENSMUST00000182651
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4870349075424693Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse

Markers in Region
AJ223069  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38672,627,204 - 72,627,293UniSTSGRCm38
MGSCv37672,577,198 - 72,577,287UniSTSGRCm37
Celera674,728,765 - 74,728,854UniSTS
Cytogenetic Map6C1UniSTS
cM Map630.4UniSTS
Whitehead/MRC_RH6716.86UniSTS
RH124429  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38672,697,708 - 72,697,804UniSTSGRCm38
MGSCv37672,647,702 - 72,647,798UniSTSGRCm37
Celera674,802,418 - 74,802,514UniSTS
Cytogenetic Map6C1UniSTS
cM Map630.4UniSTS
Tcf3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C1UniSTS
cM Map630.4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000069536   ⟹   ENSMUSP00000069403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,603,361 - 72,766,237 (-)Ensembl
GRCm38.p6 Ensembl672,626,378 - 72,789,254 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114053   ⟹   ENSMUSP00000109687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,604,255 - 72,765,935 (-)Ensembl
GRCm38.p6 Ensembl672,627,272 - 72,788,952 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,604,574 - 72,607,253 (-)Ensembl
GRCm38.p6 Ensembl672,627,591 - 72,630,270 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149446   ⟹   ENSMUSP00000115060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,609,959 - 72,765,581 (-)Ensembl
GRCm38.p6 Ensembl672,632,976 - 72,788,598 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,625,798 - 72,648,387 (-)Ensembl
GRCm38.p6 Ensembl672,648,815 - 72,671,404 (-)Ensembl
RefSeq Acc Id: NM_001079822   ⟹   NP_001073290
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,603,354 - 72,766,028 (-)NCBI
GRCm38672,626,371 - 72,789,045 (-)NCBI
MGSCv37672,576,374 - 72,738,950 (-)RGD
Celera674,727,932 - 74,893,705 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009332   ⟹   NP_033358
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,603,354 - 72,766,028 (-)NCBI
GRCm38672,626,371 - 72,789,045 (-)NCBI
MGSCv37672,576,374 - 72,738,950 (-)RGD
Celera674,727,932 - 74,893,705 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505882   ⟹   XP_006505945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,603,358 - 72,655,272 (-)NCBI
GRCm38672,626,371 - 72,671,399 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033358   ⟸   NM_009332
- Peptide Label: isoform 2
- UniProtKB: O70573 (UniProtKB/Swiss-Prot),   O70450 (UniProtKB/Swiss-Prot),   Q9Z1J1 (UniProtKB/Swiss-Prot),   A1A550 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001073290   ⟸   NM_001079822
- Peptide Label: isoform 1
- UniProtKB: Q9Z1J1 (UniProtKB/Swiss-Prot),   O70573 (UniProtKB/Swiss-Prot),   O70450 (UniProtKB/Swiss-Prot),   A1A549 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505945   ⟸   XM_006505882
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000115060   ⟸   ENSMUST00000149446
RefSeq Acc Id: ENSMUSP00000109687   ⟸   ENSMUST00000114053
RefSeq Acc Id: ENSMUSP00000069403   ⟸   ENSMUST00000069536
Protein Domains
CTNNB1 binding N-teminal   HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1J1-F1-model_v2 AlphaFold Q9Z1J1 1-584 view protein structure

Promoters
RGD ID:6840057
Promoter ID:MM_KWN:46480
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000050224
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,580,166 - 72,580,666 (-)MPROMDB
RGD ID:6840059
Promoter ID:MM_KWN:46483
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001079822,   OTTMUST00000050223,   OTTMUST00000050225,   OTTMUST00000050226
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,738,231 - 72,739,807 (-)MPROMDB
RGD ID:6890038
Promoter ID:EPDNEW_M8470
Type:multiple initiation site
Name:Tcf7l1_1
Description:Mus musculus transcription factor 7 like 1 (T cell specific,HMG box) , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38672,789,054 - 72,789,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202876 AgrOrtholog
Ensembl Genes ENSMUSG00000055799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069536 ENTREZGENE
  ENSMUST00000069536.12 UniProtKB/TrEMBL
  ENSMUST00000114053 ENTREZGENE
  ENSMUST00000114053.9 UniProtKB/TrEMBL
  ENSMUST00000149446.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCF/LEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21415 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1202876 ENTREZGENE
NCBI Gene 21415 ENTREZGENE
PANTHER PTHR10373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10373:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcf7l1 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1A549 ENTREZGENE, UniProtKB/TrEMBL
  A1A550 ENTREZGENE, UniProtKB/TrEMBL
  F6VNH1_MOUSE UniProtKB/TrEMBL
  O70450 ENTREZGENE
  O70573 ENTREZGENE
  Q3TPB1_MOUSE UniProtKB/TrEMBL
  Q9Z1J1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O70450 UniProtKB/Swiss-Prot
  O70573 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tcf7l1  transcription factor 7 like 1 (T cell specific, HMG box)  Tcf7l1  transcription factor 7-like 1 (T-cell specific, HMG box)  Symbol and/or name change 5135510 APPROVED