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Gene: Pax8 (paired box 8) Mus musculus
Symbol: Pax8
Name: paired box 8
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of nitrogen compound metabolic process; and regulation of kidney development. Localizes to nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; foregut gland; genitourinary system; and inner ear. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: paired box gene 8; paired box protein Pax-8; Pax-8
Homo sapiens (human) : PAX8 (paired box 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pax8 (paired box 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pax8 (paired box 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PAX8 (paired box 8)
Canis lupus familiaris (dog) : PAX8 (paired box 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pax8 (paired box 8)
Chlorocebus sabaeus (African green monkey) : PAX8 (paired box 8)
Heterocephalus glaber (naked mole-rat) : Pax8 (paired box 8)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBImm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pax8
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730850
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.