RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: substance-induced psychosis
Accession: DOID:8646
browse the term
Definition: Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms: exact_synonym: Drug Psychoses; Toxic Psychoses; substance-induced psychoses
primary_id: MESH:D011605 ; RDO:0006434
xref: ICD9CM:293.89
For additional species annotation, visit the
Alliance of Genome Resources .
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ACE
angiotensin I converting enzyme
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17196621
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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ADORA2A
adenosine A2a receptor
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20799992
NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
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AKT1
AKT serine/threonine kinase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:21041608
NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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CAMK2B
calcium/calmodulin dependent protein kinase II beta
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17603807
NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577
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ESR1
estrogen receptor 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19386276
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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GRM2
glutamate metabotropic receptor 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20211215
NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613
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GSTP1
glutathione S-transferase pi 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:15729709
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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HTR1A
5-hydroxytryptamine receptor 1A
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19747927
NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
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HTR6
5-hydroxytryptamine receptor 6
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20705401
NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966
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NPY1R
neuropeptide Y receptor Y1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19566775
NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832
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OPRM1
opioid receptor mu 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:16402083
NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
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PHB1
prohibitin 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:18504422
NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905
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PICK1
protein interacting with PRKCA 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17606663
NCBI chr22:38,057,255...38,075,701
Ensembl chr22:38,056,311...38,075,701
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RGS9
regulator of G protein signaling 9
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:17318883
NCBI chr17:65,137,370...65,227,703
Ensembl chr17:65,100,812...65,227,703
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SLC6A3
solute carrier family 6 member 3
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:12931138
NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
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SNCA
synuclein alpha
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:15542733
NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
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SOD2
superoxide dismutase 2
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:16807759
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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ALDH2
aldehyde dehydrogenase 2 family member
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:26711020
NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
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ANKK1
ankyrin repeat and kinase domain containing 1
IAGP
DNA:SNP:exon:rs1800497(human)
RGD
PMID:18669994
RGD:401959336
NCBI chr11:113,387,779...113,400,416
Ensembl chr11:113,387,779...113,400,416
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DRD2
dopamine receptor D2
IAGP
DNA:SNP:cds:957C>T(human)
RGD
PMID:18669994
RGD:401959336
NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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FOXO4
forkhead box O4
ISO
protein:increased phosphorylation:small intestine:
RGD
PMID:23292333
RGD:10402360
NCBI chr X:71,095,851...71,103,532
Ensembl chr X:71,095,851...71,103,535
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GSR
glutathione-disulfide reductase
treatment
ISO
RGD
PMID:24972622
RGD:10401897
NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
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HECTD4
HECT domain E3 ubiquitin protein ligase 4
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:35713687
NCBI chr12:112,160,195...112,382,431
Ensembl chr12:112,160,188...112,382,439
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HTR2A
5-hydroxytryptamine receptor 2A
IAGP
DNA:SNP:promoter:-1438G>A
RGD
PMID:11842624
RGD:401900738
NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
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ARRB2
arrestin beta 2
ISO
protein:increased expression:striatum
RGD
PMID:26174132
RGD:11534754
NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499
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DRD2
dopamine receptor D2
ISO
RGD
PMID:26174132
RGD:11534754
NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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GAD1
glutamate decarboxylase 1
susceptibility
IAGP ISO
associated with amphetamine abuse; DNA:haplotype: :rs769404���rs701492(human) protein:decreased expression:prefrontal cortex
RGD
PMID:27967329 PMID:24200867
RGD:401900122 , RGD:401900162
NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
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GAD2
glutamate decarboxylase 2
susceptibility
IAGP
associated with amphetamine abuse; DNA:SNP: :rs2236418(human)
RGD
PMID:27967329
RGD:401900122
NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
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OPRM1
opioid receptor mu 1
IAGP
associated with amphetamine abuse;DNA:SNP:intron:IVS2+691G>C (human)
RGD
PMID:16402083
RGD:401827939
NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
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ANK3
ankyrin 3
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29109170
NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490
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APOE
apolipoprotein E
ISO
RGD
PMID:15007105
RGD:12904641
NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
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BPIFA1
BPI fold containing family A member 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:15513904
NCBI chr20:33,235,996...33,243,306
Ensembl chr20:33,235,995...33,243,311
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C3
complement C3
ISO
protein:increased activity:blood
RGD
PMID:30657461
RGD:408418720
NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
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C5
complement C5
ISO
protein:increased activity:blood
RGD
PMID:30657461
RGD:408418720
NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
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CAT
catalase
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:26074427
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CRHR1
corticotropin releasing hormone receptor 1
sexual_dimorphism
ISO
associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat)
RGD
PMID:29251811
RGD:401965484
NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828
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DIO3
iodothyronine deiodinase 3
treatment
ISO
RGD
PMID:23763370
RGD:13432044
NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452
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DNMT1
DNA methyltransferase 1
ISO
mRNA,protein:increased expression:Pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
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DNMT3B
DNA methyltransferase 3 beta
ISO
mRNA:increased expression:pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359
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DRD2
dopamine receptor D2
ISO
DNA:Hypermethylation:promoter mRNA:decreased expression: pituitary gland (rat)
RGD
PMID:26509893 PMID:28710248
RGD:11344152 , RGD:401960105
NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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EHMT2
euchromatic histone lysine methyltransferase 2
ISO
mRNA:increased expression:pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698
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GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
treatment sexual_dimorphism
ISO
in male mice only; mRNA:increased expression:frontal cortex:
RGD
PMID:23763370 PMID:30312858
RGD:13432044 , RGD:405866345
NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539
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GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
ISO
mRNA:increased expression:posterior hypothalamic region (rat)
RGD
PMID:18514412
RGD:402528884
NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977
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GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
treatment
ISO
RGD
PMID:22037411 PMID:23763370
RGD:13210751 , RGD:13432044
NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
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HDAC2
histone deacetylase 2
ISO
mRNA,protein:increased expression:pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
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HDAC4
histone deacetylase 4
ISO
mRNA,protein:increased expression:pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
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HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
ISO
protein:increased expression:placenta (rat)
RGD
PMID:26342748
RGD:401965481
NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
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IGF1
insulin like growth factor 1
ISO
mRNA:decreased expression:cerebellum (rat)
RGD
PMID:16909201
RGD:12904886
NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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IGF1R
insulin like growth factor 1 receptor
ISO
protein:decreased activity:cerebellum (rat)
RGD
PMID:16909201
RGD:12904886
NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
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MAT2A
methionine adenosyltransferase 2A
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:26180184
RGD:11074449
NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281
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MECP2
methyl-CpG binding protein 2
treatment
ISO
mRNA:increased expression:pituitary gland (rat)
RGD
PMID:26509893 PMID:23763370
RGD:11344152 , RGD:13432044
NCBI chr X:154,021,573...154,097,717
Ensembl chr X:154,021,573...154,137,103
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MIR326
microRNA 326
ISO
miRNA:increases expression:pituitary gland (rat)
RGD
PMID:28710248
RGD:401960105
NCBI chr11:75,335,092...75,335,186
Ensembl chr11:75,335,092...75,335,186
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MIR7-3
microRNA 7-3
ISO
miRNA:increased expression:pituitary gland (rat)
RGD
PMID:28710248
RGD:401960105
NCBI chr19:4,770,670...4,770,779
Ensembl chr19:4,770,670...4,770,779
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MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:26180184
RGD:11074449
NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278
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NOS1
nitric oxide synthase 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25511929
NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
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NR3C2
nuclear receptor subfamily 3 group C member 2
sexual_dimorphism
ISO
associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat)
RGD
PMID:29251811
RGD:401965484
NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
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OPRK1
opioid receptor kappa 1
ISO
DNA, mRNA:hypomethylation, increased expression:ventral tegmental area, prefrontal cortex
RGD
PMID:29678771
RGD:401851055
NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637
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OPRL1
opioid related nociceptin receptor 1
ISO
mRNA:decreased expression:ventral tegmental area
RGD
PMID:29678771
RGD:401851055
NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643
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PDYN
prodynorphin
ISO
DNA, mRNA:hypomethylation, altered expression:ventral tegmental area, nucleus accumbens
RGD
PMID:29678771
RGD:401851055
NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285
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PER2
period circadian regulator 2
treatment
IDA
RGD
PMID:31329297
RGD:405878078
NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102
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PNOC
prepronociceptin
ISO
mRNA:increased expression:nucleus accumbens
RGD
PMID:29678771
RGD:401851055
NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355
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POMC
proopiomelanocortin
treatment
IDA
RGD
PMID:31329297
RGD:405878078
NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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PRL
prolactin
ISO
mRNA,protein:increased expression:pituitary gland, blood plasma (rat) mRNA, protein:increased expression:pituitary gland, blood plasma (rat)
RGD
PMID:26509893 PMID:28710248
RGD:11344152 , RGD:401960105
NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
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PTEN
phosphatase and tensin homolog
ISO
Protein:increased expression, increased activity:cerebellum (rat)
RGD
PMID:12700235
RGD:12801493
NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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RASGRF1
Ras protein specific guanine nucleotide releasing factor 1
treatment
ISO
RGD
PMID:23763370
RGD:13432044
NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780
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RPS6KA1
ribosomal protein S6 kinase A1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:29109170
NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030
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SETD7
SET domain containing 7, histone lysine methyltransferase
ISO
mRNA:decreased expression:pituitary gland (rat)
RGD
PMID:26509893
RGD:11344152
NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699
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SLC25A12
solute carrier family 25 member 12
treatment
ISO
RGD
PMID:23763370
RGD:13432044
NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859
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SLC6A4
solute carrier family 6 member 4
ISO
mRNA:decreased expression:brain (rat)
RGD
PMID:26180184
RGD:11074449
NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
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TLR4
toll like receptor 4
ameliorates
ISO
RGD
PMID:30312858
RGD:405866345
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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UBE3A
ubiquitin protein ligase E3A
treatment
ISO
RGD
PMID:23763370
RGD:13432044
NCBI chr15:25,333,728...25,439,056
Ensembl chr15:25,333,728...25,439,051
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RHOA
ras homolog family member A
ISO
protein:increased activation:neuron, cerebellum
RGD
PMID:17109064
RGD:2298867
NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:24814703
RGD:10047100
NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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BDNF
brain derived neurotrophic factor
treatment
ISO IEP
associated with brain ischemia
RGD
PMID:29571823 PMID:33324197 PMID:29599834 PMID:34964700
RGD:401959211 , RGD:405850212 , RGD:401976548 , RGD:401965400
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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CREB1
cAMP responsive element binding protein 1
treatment
ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:29571823 PMID:37736695 PMID:36688960
RGD:401959211 , RGD:401960090 , RGD:401959611
NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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GDNF
glial cell derived neurotrophic factor
treatment
ISO IEP
protein:decreased expression:hippocampus,urine protein:altered expression:hippocampus, urine associated with rheumatic heart disease;protein:increased expression:serum
RGD
PMID:36688960 PMID:34728231 PMID:29512789 PMID:28918204 PMID:33324197 PMID:25251457 More...
RGD:401959611 , RGD:405866364 , RGD:405850251 , RGD:405850250 , RGD:405850212 , RGD:405849389
NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041
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IGFBP7
insulin like growth factor binding protein 7
IEP
protein:increased expression:plasma (human)
RGD
PMID:25543030
RGD:401960875
NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385
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IL1B
interleukin 1 beta
treatment
ISO
protein:increased expression:hippocampus (rat)
RGD
PMID:22959208 PMID:33390808 PMID:29571823
RGD:7204702 , RGD:401965467 , RGD:401959211
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1RN
interleukin 1 receptor antagonist
treatment
IDA
human protein in a rat model
RGD
PMID:23077050
RGD:8551854
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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IL6
interleukin 6
ISO
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808
RGD:401965467
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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IREB2
iron responsive element binding protein 2
ISO
protein:increased expression:hippocampus (rat)
RGD
PMID:23229539
RGD:12904023
NCBI chr15:78,437,431...78,501,453
Ensembl chr15:78,437,431...78,501,453
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MAPK1
mitogen-activated protein kinase 1
treatment
ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
G
MAPK3
mitogen-activated protein kinase 3
treatment
ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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NGF
nerve growth factor
treatment
ISO IEP IDA
associated with brain ischemia
RGD
PMID:30481505 PMID:29599834 PMID:30481505 PMID:34964700
RGD:401965395 , RGD:401976548 , RGD:401965395 , RGD:401965400
NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
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NR3C1
nuclear receptor subfamily 3 group C member 1
treatment
ISO
associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus
RGD
PMID:28086911 PMID:36637480
RGD:408345237 , RGD:408364984
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
G
NR3C2
nuclear receptor subfamily 3 group C member 2
ISO
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808
RGD:401965467
NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
G
TNF
tumor necrosis factor
treatment
ISO
protein:increased expression:hippocampus (rat)
RGD
PMID:29571823 PMID:33390808
RGD:401959211 , RGD:401965467
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
G
ACHE
acetylcholinesterase (Yt blood group)
disease_progression
IDA
RGD
PMID:8043620
RGD:405855847
NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
G
HTR1A
5-hydroxytryptamine receptor 1A
ISO
mRNA, protein:increased expression:hippocampal formation, amygdala
RGD
PMID:27760517
RGD:405850209
NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all