IGFBP7 (insulin like growth factor binding protein 7) - Rat Genome Database

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Gene: IGFBP7 (insulin like growth factor binding protein 7) Homo sapiens
Analyze
Symbol: IGFBP7
Name: insulin like growth factor binding protein 7
RGD ID: 1314683
HGNC Page HGNC:5476
Description: Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell adhesion. Located in collagen-containing extracellular matrix and extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AGM; angiomodulin; FSTL2; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-7v; IGFBP-rP1; IGFBPRP1; insulin-like growth factor binding protein 7; insulin-like growth factor-binding protein 7; MAC25; PGI2-stimulating factor; prostacyclin-stimulating factor; PSF; RAMSVPS; TAF; tumor-derived adhesion factor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38457,030,773 - 57,110,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl457,030,773 - 57,110,385 (-)EnsemblGRCh38hg38GRCh38
GRCh37457,896,939 - 57,976,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,592,001 - 57,671,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34457,738,173 - 57,817,467NCBI
Celera455,402,268 - 55,481,287 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,850,811 - 53,930,091 (-)NCBIHuRef
CHM1_1457,933,093 - 58,012,367 (-)NCBICHM1_1
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
arachidonic acid  (EXP)
arotinoid acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (EXP)
carnosic acid  (ISO)
CHIR 99021  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (EXP)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (EXP)
dibromoacetic acid  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (EXP)
dipentyl phthalate  (ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (EXP)
etoposide  (EXP)
folic acid  (EXP,ISO)
furan  (ISO)
graphene oxide  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
lead diacetate  (EXP)
mercury dibromide  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
mitoxantrone  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rotenone  (ISO)
Salinomycin  (EXP)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (ISO)
topotecan  (EXP,ISO)
triacsin C  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
XAV939  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. Cheriyan VT, etal., PLoS One. 2014 Apr 1;9(4):e93711. doi: 10.1371/journal.pone.0093711. eCollection 2014.
2. Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease. Gao R, etal., Front Endocrinol (Lausanne). 2022 Aug 12;13:967016. doi: 10.3389/fendo.2022.967016. eCollection 2022.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study. Godina C, etal., Carcinogenesis. 2021 Nov 12;42(11):1314-1325. doi: 10.1093/carcin/bgab090.
5. The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction. Jiang J, etal., Neurosci Lett. 2015 Feb 19;588:125-30. doi: 10.1016/j.neulet.2014.12.046. Epub 2014 Dec 24.
6. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Lang CH, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R207-15.
7. Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease. Li T, etal., Lipids Health Dis. 2019 Dec 5;18(1):211. doi: 10.1186/s12944-019-1154-9.
8. Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25). Lopez-Bermejo A, etal., Diabetes. 2006 Aug;55(8):2333-9.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Qin D, etal., Iran J Basic Med Sci. 2014 Nov;17(11):879-85.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
14. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Tanaka T, etal., Am J Pathol. 2000 Jun;156(6):2149-57.
15. Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease. Yan H, etal., Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1101-1110. doi: 10.1111/1440-1681.13159. Epub 2019 Aug 29.
16. Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease. Yao K, etal., Hepatol Commun. 2022 Jul;6(7):1598-1610. doi: 10.1002/hep4.1940. Epub 2022 Mar 21.
Additional References at PubMed
PMID:7538673   PMID:7694637   PMID:7980422   PMID:8117260   PMID:8710880   PMID:8939990   PMID:9100611   PMID:9313760   PMID:9388210   PMID:10502291   PMID:10595934   PMID:10820148  
PMID:10859029   PMID:10985926   PMID:11549700   PMID:12065244   PMID:12407018   PMID:12477932   PMID:12592389   PMID:12679483   PMID:12843194   PMID:12847218   PMID:14521955   PMID:14633696  
PMID:15077158   PMID:15340161   PMID:15489334   PMID:15708897   PMID:16302002   PMID:17048309   PMID:17136345   PMID:17312390   PMID:17465992   PMID:17972510   PMID:18160415   PMID:18267069  
PMID:18711401   PMID:18981723   PMID:19019211   PMID:19374835   PMID:19542015   PMID:19638426   PMID:19710688   PMID:19829302   PMID:19919630   PMID:20029996   PMID:20407444   PMID:20433702  
PMID:20440262   PMID:20464481   PMID:20478260   PMID:20535151   PMID:20551380   PMID:20599521   PMID:20977730   PMID:21040219   PMID:21095038   PMID:21328580   PMID:21413833   PMID:21525788  
PMID:21562573   PMID:21835307   PMID:21873635   PMID:21908579   PMID:21909106   PMID:21988832   PMID:22005787   PMID:22173745   PMID:22277373   PMID:22383111   PMID:22392074   PMID:22544761  
PMID:22622471   PMID:22750143   PMID:22906661   PMID:22939629   PMID:23250396   PMID:23376485   PMID:23381221   PMID:23382691   PMID:23388612   PMID:23533145   PMID:23543219   PMID:23546957  
PMID:23600329   PMID:23713052   PMID:24067438   PMID:24075854   PMID:24357797   PMID:24373620   PMID:24427302   PMID:24632618   PMID:24675717   PMID:24737780   PMID:24743871   PMID:24894674  
PMID:24967962   PMID:25037231   PMID:25789970   PMID:25796446   PMID:25880247   PMID:25886299   PMID:25887188   PMID:25984973   PMID:26043748   PMID:26387651   PMID:26450156   PMID:26474694  
PMID:26606754   PMID:26706909   PMID:26797672   PMID:26974954   PMID:27068509   PMID:27174659   PMID:27342580   PMID:27342582   PMID:27559042   PMID:27744089   PMID:27989801   PMID:28003188  
PMID:28035363   PMID:28107490   PMID:28288210   PMID:28382566   PMID:28682920   PMID:28684903   PMID:28803769   PMID:29067463   PMID:29145491   PMID:29242275   PMID:29563502   PMID:29580038  
PMID:29592874   PMID:29622288   PMID:29991293   PMID:30300282   PMID:30540936   PMID:30769262   PMID:30834595   PMID:30982674   PMID:31267558   PMID:31287495   PMID:31540324   PMID:31545454  
PMID:31730227   PMID:31741433   PMID:31791043   PMID:31822054   PMID:31856559   PMID:32066522   PMID:32406612   PMID:32475626   PMID:32479185   PMID:32529639   PMID:32548968   PMID:32908313  
PMID:33009198   PMID:33111431   PMID:33158949   PMID:33189655   PMID:33253093   PMID:33411755   PMID:33441876   PMID:34040195   PMID:34217226   PMID:34303194   PMID:34438446   PMID:34946293  
PMID:35076852   PMID:35170890   PMID:35204773   PMID:35307071   PMID:35469565   PMID:35563538   PMID:35604859   PMID:35625639   PMID:35696571   PMID:35900339   PMID:36088651   PMID:36215168  
PMID:36966971   PMID:37270777   PMID:37298628   PMID:37304887   PMID:37316358   PMID:37714372   PMID:38218180  


Genomics

Comparative Map Data
IGFBP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38457,030,773 - 57,110,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl457,030,773 - 57,110,385 (-)EnsemblGRCh38hg38GRCh38
GRCh37457,896,939 - 57,976,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,592,001 - 57,671,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34457,738,173 - 57,817,467NCBI
Celera455,402,268 - 55,481,287 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,850,811 - 53,930,091 (-)NCBIHuRef
CHM1_1457,933,093 - 58,012,367 (-)NCBICHM1_1
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBIT2T-CHM13v2.0
Igfbp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,497,092 - 77,555,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,497,087 - 77,555,888 (-)EnsemblGRCm39 Ensembl
GRCm38577,349,240 - 77,408,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv37577,778,265 - 77,837,070 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,424,020 - 78,482,816 (-)NCBIMGSCv36mm8
Celera574,616,957 - 74,675,885 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.71NCBI
Igfbp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,091,681 - 31,151,623 (+)NCBIGRCr8
mRatBN7.21430,737,414 - 30,797,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,117,785 - 31,178,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,426,112 - 32,486,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,910,759 - 30,971,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,010,300 - 33,070,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,803,851 - 32,863,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,010,198 - 33,070,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,010,197 - 33,070,052 (+)NCBI
Celera1430,057,050 - 30,116,691 (+)NCBICelera
Cytogenetic Map14p11NCBI
Igfbp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,047,732 - 14,108,414 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,048,834 - 14,110,264 (+)NCBIChiLan1.0ChiLan1.0
IGFBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,662,038 - 72,744,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,870,306 - 72,949,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,808,845 - 66,888,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,382,745 - 73,462,087 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,382,745 - 73,462,087 (+)Ensemblpanpan1.1panPan2
IGFBP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,138,406 - 49,207,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBIUU_Cfam_GSD_1.0
Igfbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,102,600 - 27,178,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,118,321 - 19,186,685 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,119,339 - 19,186,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,279,895 - 56,357,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,283,089 - 56,357,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,064,683 - 59,139,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,617,096 - 11,694,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606612,195,308 - 12,273,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,318,006 - 12,387,582 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,318,571 - 12,387,489 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IGFBP7
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001553.3(IGFBP7):c.830-1G>A single nucleotide variant Familial retinal arterial macroaneurysm [RCV003987330]|Retinal arterial macroaneurysm with supravascular pulmonic stenosis [RCV000023215] Chr4:57031337 [GRCh38]
Chr4:57897503 [GRCh37]
Chr4:4q12
pathogenic
GRCh38/hg38 4p13-q13.1(chr4:44356201-62245882)x3 copy number gain See cases [RCV000050683] Chr4:44356201..62245882 [GRCh38]
Chr4:44358218..63111600 [GRCh37]
Chr4:44052975..62794195 [NCBI36]
Chr4:4p13-q13.1
pathogenic
GRCh38/hg38 4q12-13.2(chr4:51831622-66991489)x3 copy number gain See cases [RCV000051771] Chr4:51831622..66991489 [GRCh38]
Chr4:52697788..67857207 [GRCh37]
Chr4:52392545..67539802 [NCBI36]
Chr4:4q12-13.2
pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q12-13.1(chr4:51899860-59984479)x3 copy number gain See cases [RCV000051773] Chr4:51899860..59984479 [GRCh38]
Chr4:52766026..60850197 [GRCh37]
Chr4:52460783..60532792 [NCBI36]
Chr4:4q12-13.1
pathogenic
GRCh38/hg38 4q12-13.1(chr4:52639018-59984479)x1 copy number loss See cases [RCV000053265] Chr4:52639018..59984479 [GRCh38]
Chr4:53505185..60850197 [GRCh37]
Chr4:53199942..60532792 [NCBI36]
Chr4:4q12-13.1
pathogenic
GRCh38/hg38 4q12-13.1(chr4:54198601-62270115)x1 copy number loss See cases [RCV000053266] Chr4:54198601..62270115 [GRCh38]
Chr4:55064768..63135833 [GRCh37]
Chr4:54759525..62818428 [NCBI36]
Chr4:4q12-13.1
pathogenic
NM_000938.2(POLR2B):c.3370A>G (p.Ile1124Val) single nucleotide variant Malignant melanoma [RCV000066468] Chr4:57030334 [GRCh38]
Chr4:57896500 [GRCh37]
Chr4:57591257 [NCBI36]
Chr4:4q12
not provided
GRCh38/hg38 4q12(chr4:56248102-57218522)x4 copy number gain See cases [RCV000137649] Chr4:56248102..57218522 [GRCh38]
Chr4:57114268..58084688 [GRCh37]
Chr4:56809025..57779445 [NCBI36]
Chr4:4q12
uncertain significance
GRCh37/hg19 4q12(chr4:57915534-58084629)x3 copy number gain See cases [RCV000446239] Chr4:57915534..58084629 [GRCh37]
Chr4:4q12
benign
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q13.1(chr4:68345-66440622)x3 copy number gain See cases [RCV000511193] Chr4:68345..66440622 [GRCh37]
Chr4:4p16.3-q13.1
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q12(chr4:57859592-58005459)x3 copy number gain not provided [RCV000743598] Chr4:57859592..58005459 [GRCh37]
Chr4:4q12
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001553.3(IGFBP7):c.703-10T>C single nucleotide variant not provided [RCV000964408] Chr4:57032562 [GRCh38]
Chr4:57898728 [GRCh37]
Chr4:4q12
benign
GRCh37/hg19 4q12-13.1(chr4:57932502-59894298)x3 copy number gain not provided [RCV000848860] Chr4:57932502..59894298 [GRCh37]
Chr4:4q12-13.1
uncertain significance
GRCh37/hg19 4q12(chr4:57067953-57957651)x3 copy number gain not provided [RCV001005548] Chr4:57067953..57957651 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.561G>A (p.Pro187=) single nucleotide variant not provided [RCV000974447] Chr4:57040848 [GRCh38]
Chr4:57907014 [GRCh37]
Chr4:4q12
benign
NM_001553.3(IGFBP7):c.684del (p.Glu228_Val229insTer) deletion Retinal arterial macroaneurysm with supravalvular pulmonic stenosis [RCV001328853] Chr4:57033213 [GRCh38]
Chr4:57899379 [GRCh37]
Chr4:4q12
pathogenic
GRCh38/hg38 4q12-21.1(chr4:51891814-76009719)x1 copy number loss Piebaldism [RCV001420508] Chr4:51891814..76009719 [GRCh38]
Chr4:4q12-21.1
pathogenic
NM_001553.3(IGFBP7):c.585+4T>A single nucleotide variant Familial retinal arterial macroaneurysm [RCV001730169] Chr4:57040820 [GRCh38]
Chr4:57906986 [GRCh37]
Chr4:4q12
benign
NM_001553.3(IGFBP7):c.829G>A (p.Gly277Ser) single nucleotide variant Familial retinal arterial macroaneurysm [RCV001844360] Chr4:57032426 [GRCh38]
Chr4:57898592 [GRCh37]
Chr4:4q12
pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
GRCh37/hg19 4q11-12(chr4:52685685-58104722)x1 copy number loss not provided [RCV001829079] Chr4:52685685..58104722 [GRCh37]
Chr4:4q11-12
pathogenic
GRCh37/hg19 4q11-12(chr4:52685980-59272025)x3 copy number gain not provided [RCV002473779] Chr4:52685980..59272025 [GRCh37]
Chr4:4q11-12
uncertain significance
NM_001553.3(IGFBP7):c.229G>A (p.Gly77Ser) single nucleotide variant Inborn genetic diseases [RCV002687827] Chr4:57110123 [GRCh38]
Chr4:57976289 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.370G>A (p.Gly124Ser) single nucleotide variant Inborn genetic diseases [RCV002993135] Chr4:57109982 [GRCh38]
Chr4:57976148 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.314C>G (p.Pro105Arg) single nucleotide variant Inborn genetic diseases [RCV002865700] Chr4:57110038 [GRCh38]
Chr4:57976204 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.226G>A (p.Ala76Thr) single nucleotide variant Inborn genetic diseases [RCV002782251] Chr4:57110126 [GRCh38]
Chr4:57976292 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.730G>A (p.Gly244Arg) single nucleotide variant Inborn genetic diseases [RCV002830707] Chr4:57032525 [GRCh38]
Chr4:57898691 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.841G>A (p.Glu281Lys) single nucleotide variant Inborn genetic diseases [RCV002709488] Chr4:57031325 [GRCh38]
Chr4:57897491 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.233G>A (p.Arg78Lys) single nucleotide variant Inborn genetic diseases [RCV002955198] Chr4:57110119 [GRCh38]
Chr4:57976285 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.255G>A (p.Met85Ile) single nucleotide variant Inborn genetic diseases [RCV002748262] Chr4:57110097 [GRCh38]
Chr4:57976263 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.487G>C (p.Val163Leu) single nucleotide variant Inborn genetic diseases [RCV003008822] Chr4:57040922 [GRCh38]
Chr4:57907088 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.167C>T (p.Ala56Val) single nucleotide variant Inborn genetic diseases [RCV002936405] Chr4:57110185 [GRCh38]
Chr4:57976351 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.250G>A (p.Gly84Ser) single nucleotide variant Inborn genetic diseases [RCV002656237] Chr4:57110102 [GRCh38]
Chr4:57976268 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.310G>A (p.Gly104Ser) single nucleotide variant Inborn genetic diseases [RCV002724651] Chr4:57110042 [GRCh38]
Chr4:57976208 [GRCh37]
Chr4:4q12
uncertain significance
NM_001553.3(IGFBP7):c.723A>C (p.Glu241Asp) single nucleotide variant Inborn genetic diseases [RCV003204402] Chr4:57032532 [GRCh38]
Chr4:57898698 [GRCh37]
Chr4:4q12
likely benign
GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 copy number gain Neurodevelopmental disorder [RCV003327613] Chr4:85624..57073230 [GRCh38]
Chr4:4p16.3-q12
pathogenic
GRCh37/hg19 4q12-13.3(chr4:57584845-72430996)x1 copy number loss not provided [RCV003485417] Chr4:57584845..72430996 [GRCh37]
Chr4:4q12-13.3
pathogenic
GRCh37/hg19 4q11-13.1(chr4:52685685-61903883)x1 copy number loss not provided [RCV003485416] Chr4:52685685..61903883 [GRCh37]
Chr4:4q11-13.1
pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2
pathogenic
NM_001553.3(IGFBP7):c.431G>A (p.Gly144Glu) single nucleotide variant IGFBP7-related condition [RCV003959577] Chr4:57109921 [GRCh38]
Chr4:57976087 [GRCh37]
Chr4:4q12
likely benign
NM_001553.3(IGFBP7):c.101C>A (p.Pro34His) single nucleotide variant IGFBP7-related condition [RCV003942147] Chr4:57110251 [GRCh38]
Chr4:57976417 [GRCh37]
Chr4:4q12
likely benign
NM_001553.3(IGFBP7):c.403G>A (p.Ala135Thr) single nucleotide variant IGFBP7-related condition [RCV003934310] Chr4:57109949 [GRCh38]
Chr4:57976115 [GRCh37]
Chr4:4q12
benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:419
Count of miRNA genes:270
Interacting mature miRNAs:301
Transcripts:ENST00000295666, ENST00000537922
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-60117  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,946,353 - 57,946,518UniSTSGRCh37
Build 36457,641,110 - 57,641,275RGDNCBI36
Celera455,451,340 - 55,451,505RGD
Cytogenetic Map4q12UniSTS
HuRef453,899,949 - 53,900,114UniSTS
TNG Radiation Hybrid Map431767.0UniSTS
SHGC-12841  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,897,272 - 57,897,495UniSTSGRCh37
Build 36457,592,029 - 57,592,252RGDNCBI36
Celera455,402,296 - 55,402,519RGD
Cytogenetic Map4q12UniSTS
HuRef453,850,846 - 53,851,069UniSTS
TNG Radiation Hybrid Map431905.0UniSTS
GeneMap99-G3 RH Map43362.0UniSTS
SHGC-67219  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,935,091 - 57,935,341UniSTSGRCh37
Build 36457,629,848 - 57,630,098RGDNCBI36
Celera455,440,098 - 55,440,344RGD
Cytogenetic Map4q12UniSTS
HuRef453,888,703 - 53,888,949UniSTS
TNG Radiation Hybrid Map443696.0UniSTS
RH103252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,906,160 - 57,906,346UniSTSGRCh37
Build 36457,600,917 - 57,601,103RGDNCBI36
Celera455,411,175 - 55,411,361RGD
Cytogenetic Map4q12UniSTS
HuRef453,859,788 - 53,859,974UniSTS
GeneMap99-GB4 RH Map4353.17UniSTS
SHGC-24442  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,968,100 - 57,968,200UniSTSGRCh37
Build 36457,662,857 - 57,662,957RGDNCBI36
Celera455,473,065 - 55,473,165RGD
Cytogenetic Map4q12UniSTS
HuRef453,921,630 - 53,921,730UniSTS
TNG Radiation Hybrid Map431752.0UniSTS
STS-AA005396  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,935,092 - 57,935,263UniSTSGRCh37
Build 36457,629,849 - 57,630,020RGDNCBI36
Celera455,440,099 - 55,440,266RGD
Cytogenetic Map4q12UniSTS
HuRef453,888,704 - 53,888,871UniSTS
GeneMap99-GB4 RH Map4353.86UniSTS
SHGC-50868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,967,996 - 57,968,200UniSTSGRCh37
Build 36457,662,753 - 57,662,957RGDNCBI36
Celera455,472,961 - 55,473,165RGD
Cytogenetic Map4q12UniSTS
HuRef453,921,526 - 53,921,730UniSTS
TNG Radiation Hybrid Map431730.0UniSTS
STS-H49911  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,906,179 - 57,906,308UniSTSGRCh37
Build 36457,600,936 - 57,601,065RGDNCBI36
Celera455,411,194 - 55,411,323RGD
Cytogenetic Map4q12UniSTS
HuRef453,859,807 - 53,859,936UniSTS
TNG Radiation Hybrid Map431785.0UniSTS
GeneMap99-GB4 RH Map4353.74UniSTS
SHGC-8252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,967,923 - 57,968,016UniSTSGRCh37
Build 36457,662,680 - 57,662,773RGDNCBI36
Celera455,472,888 - 55,472,981RGD
Cytogenetic Map4q12UniSTS
HuRef453,921,453 - 53,921,546UniSTS
G16771  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,946,541 - 57,946,679UniSTSGRCh37
Build 36457,641,298 - 57,641,436RGDNCBI36
Celera455,451,528 - 55,451,666RGD
Cytogenetic Map4q12UniSTS
HuRef453,900,137 - 53,900,275UniSTS
MARC_7319-7320:996687770:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37457,898,677 - 57,899,399UniSTSGRCh37
Build 36457,593,434 - 57,594,156RGDNCBI36
Celera455,403,701 - 55,404,423RGD
HuRef453,852,251 - 53,852,973UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 127 1402 603 18 23 19 1317 76 386 178 220 715 475 1027
Medium 2205 1419 1106 597 1182 436 2905 2084 3291 230 1190 774 170 729 1761 1
Low 32 163 9 7 291 7 126 16 24 6 33 71 3 1 3 1
Below cutoff 59 6 4 2 251 3 5 15 26 4 13 41 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_031877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI761388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY518539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS138158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S75725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000295666   ⟹   ENSP00000295666
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,030,773 - 57,110,385 (-)Ensembl
RefSeq Acc Id: ENST00000512512
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,030,773 - 57,065,603 (-)Ensembl
RefSeq Acc Id: ENST00000514062   ⟹   ENSP00000486293
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl457,032,038 - 57,110,385 (-)Ensembl
RefSeq Acc Id: NM_001253835   ⟹   NP_001240764
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38457,032,259 - 57,110,385 (-)NCBI
GRCh37457,897,237 - 57,976,551 (-)NCBI
HuRef453,850,811 - 53,930,091 (-)NCBI
CHM1_1457,934,260 - 58,012,367 (-)NCBI
T2T-CHM13v2.0460,523,696 - 60,601,772 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001553   ⟹   NP_001544
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38457,030,773 - 57,110,385 (-)NCBI
GRCh37457,897,237 - 57,976,551 (-)NCBI
Build 36457,592,001 - 57,671,296 (-)NCBI Archive
HuRef453,850,811 - 53,930,091 (-)NCBI
CHM1_1457,933,093 - 58,012,367 (-)NCBI
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001544   ⟸   NM_001553
- Peptide Label: isoform 1 precursor
- UniProtKB: Q53YE6 (UniProtKB/Swiss-Prot),   Q07822 (UniProtKB/Swiss-Prot),   B7Z9W7 (UniProtKB/Swiss-Prot),   B4E1N2 (UniProtKB/Swiss-Prot),   Q9UCA8 (UniProtKB/Swiss-Prot),   Q16270 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240764   ⟸   NM_001253835
- Peptide Label: isoform 2 precursor
- UniProtKB: Q16270 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000295666   ⟸   ENST00000295666
RefSeq Acc Id: ENSP00000486293   ⟸   ENST00000514062
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q16270-F1-model_v2 AlphaFold Q16270 1-282 view protein structure

Promoters
RGD ID:6867544
Promoter ID:EPDNEW_H6937
Type:initiation region
Name:IGFBP7_1
Description:insulin like growth factor binding protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6938  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38457,110,385 - 57,110,445EPDNEW
RGD ID:6867546
Promoter ID:EPDNEW_H6938
Type:initiation region
Name:IGFBP7_2
Description:insulin like growth factor binding protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6937  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38457,110,543 - 57,110,603EPDNEW
RGD ID:6852276
Promoter ID:EP73944
Type:multiple initiation site
Name:HS_IGFBP7
Description:Insulin-like growth factor binding protein 7.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,671,308 - 57,671,368EPD
RGD ID:6802378
Promoter ID:HG_KWN:48321
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:OTTHUMT00000250693
Position:
Human AssemblyChrPosition (strand)Source
Build 36457,671,366 - 57,671,867 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5476 AgrOrtholog
COSMIC IGFBP7 COSMIC
Ensembl Genes ENSG00000163453 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000295666 ENTREZGENE
  ENST00000295666.6 UniProtKB/Swiss-Prot
  ENST00000514062 ENTREZGENE
  ENST00000514062.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.30.60.30 UniProtKB/Swiss-Prot
  4.10.40.20 UniProtKB/Swiss-Prot
GTEx ENSG00000163453 GTEx
HGNC ID HGNC:5476 ENTREZGENE
Human Proteome Map IGFBP7 Human Proteome Map
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_rP_mac25 UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3490 UniProtKB/Swiss-Prot
NCBI Gene 3490 ENTREZGENE
OMIM 602867 OMIM
PANTHER INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 UniProtKB/Swiss-Prot
  PTHR14186 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  IGFBP UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
PharmGKB PA29709 PharmGKB
PIRSF IGFBP_rP_mac25 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt B4E1N2 ENTREZGENE
  B7Z9W7 ENTREZGENE
  IBP7_HUMAN UniProtKB/Swiss-Prot
  Q07822 ENTREZGENE
  Q16270 ENTREZGENE
  Q53YE6 ENTREZGENE
  Q9UCA8 ENTREZGENE
UniProt Secondary B4E1N2 UniProtKB/Swiss-Prot
  B7Z9W7 UniProtKB/Swiss-Prot
  Q07822 UniProtKB/Swiss-Prot
  Q53YE6 UniProtKB/Swiss-Prot
  Q9UCA8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 IGFBP7  insulin like growth factor binding protein 7  IGFBP7  insulin-like growth factor binding protein 7  Symbol and/or name change 5135510 APPROVED