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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314683
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFBP7
Name: insulin like growth factor binding protein 7
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP7affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of IGFBP7 promoterPMID:27901495
IGFBP7increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IGFBP7 mRNAPMID:20106945 PMID:21632981 PMID:22316170 PMID:32234424
IGFBP7decreases expressionISOIgfbp7 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGFBP7 mRNAPMID:15034205
IGFBP7increases expressionISOIgfbp7 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of IGFBP7 mRNAPMID:22228805
IGFBP7multiple interactionsISOIgfbp7 (Mus musculus)6480464CTDAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGFBP7 mRNA]PMID:15034205
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