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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:substance-induced psychosis
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Accession:DOID:8646 term browser browse the term
Definition:Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms:exact_synonym: Drug Psychoses;   Toxic Psychoses;   substance-induced psychoses
 primary_id: MESH:D011605;   RDO:0006434
 xref: ICD9CM:293.89
For additional species annotation, visit the Alliance of Genome Resources.


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substance-induced psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme EXP CTD Direct Evidence: marker/mechanism CTD PMID:17196621 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ADORA2A adenosine A2a receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G AKT1 AKT serine/threonine kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:17603807 NCBI chr 7:44,217,154...44,326,167
Ensembl chr 7:44,217,150...44,334,577
JBrowse link
G ESR1 estrogen receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19386276 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G GRM2 glutamate metabotropic receptor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr 3:51,707,068...51,718,616
Ensembl chr 3:51,707,068...51,718,613
JBrowse link
G GSTP1 glutathione S-transferase pi 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A EXP CTD Direct Evidence: marker/mechanism CTD PMID:19747927 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,960,356...63,962,507
Ensembl chr 5:63,960,356...63,962,507
JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966
JBrowse link
G NPY1R neuropeptide Y receptor Y1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chr 4:163,323,962...163,344,832
Ensembl chr 4:163,323,962...163,344,832
JBrowse link
G OPRM1 opioid receptor mu 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PHB prohibitin EXP CTD Direct Evidence: marker/mechanism CTD PMID:18504422 NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905
Ensembl chr17:49,404,049...49,414,905
JBrowse link
G PICK1 protein interacting with PRKCA 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr22:38,056,311...38,075,704
Ensembl chr22:38,056,311...38,075,701
JBrowse link
G RGS9 regulator of G protein signaling 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17318883 NCBI chr17:65,137,370...65,227,703
Ensembl chr17:65,100,812...65,227,703
JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SNCA synuclein alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:15542733 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD2 superoxide dismutase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16807759 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member EXP CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G FOXO4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:71,095,851...71,103,534
Ensembl chr  X:71,095,851...71,103,532
JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
drug psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 ISO RGD PMID:26174132 RGD:11534754 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490
JBrowse link
G APOE apolipoprotein E ISO RGD PMID:15007105 RGD:12904641 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G BPIFA1 BPI fold containing family A member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr20:33,235,996...33,243,306
Ensembl chr20:33,235,995...33,243,311
JBrowse link
G CAT catalase EXP CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B treatment ISO RGD PMID:22037411, PMID:23763370 RGD:13210751, RGD:13432044 NCBI chr12:13,537,337...13,982,012
Ensembl chr12:13,437,942...13,982,002
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G NOS1 nitric oxide synthase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G PTEN phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 1:26,529,761...26,575,028
Ensembl chr 1:26,529,761...26,575,030
JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOA ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:24814703 RGD:10047100 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:22959208 RGD:7204702 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment IDA human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IREB2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr15:78,437,431...78,501,453
Ensembl chr15:78,437,431...78,501,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18952
    Chemically-Induced Disorders 1178
      substance-related disorder 548
        substance-induced psychosis 36
          alcohol-induced mental disorder + 14
          alcoholic psychosis 0
          drug-induced mental disorder + 1
          subacute delirium + 4
Path 2
Term Annotations click to browse term
  disease 18952
    disease of anatomical entity 17438
      nervous system disease 13527
        central nervous system disease 11589
          brain disease 10775
            disease of mental health 8268
              cognitive disorder 2689
                psychotic disorder 1919
                  substance-induced psychosis 36
                    alcohol-induced mental disorder + 14
                    alcoholic psychosis 0
                    drug-induced mental disorder + 1
                    subacute delirium + 4
paths to the root