PICK1 (protein interacting with PRKCA 1) - Rat Genome Database

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Gene: PICK1 (protein interacting with PRKCA 1) Homo sapiens
Analyze
Symbol: PICK1
Name: protein interacting with PRKCA 1
RGD ID: 69496
HGNC Page HGNC
Description: Enables several functions, including identical protein binding activity; membrane curvature sensor activity; and protein C-terminus binding activity. Involved in monoamine transport; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of insulin secretion. Located in cytosol and presynaptic membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC15204; PICK; PRKCA-binding protein; PRKCABP; protein interacting with C kinase 1; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with c kinase 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2238,056,311 - 38,075,701 (+)EnsemblGRCh38hg38GRCh38
GRCh382238,056,311 - 38,075,704 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,453,262 - 38,471,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,783,208 - 36,801,654 (+)NCBINCBI36hg18NCBI36
Build 342236,777,902 - 36,796,207NCBI
Celera2222,255,002 - 22,273,457 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,417,897 - 21,436,386 (+)NCBIHuRef
CHM1_12238,411,992 - 38,430,442 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7844141   PMID:8125298   PMID:9405395   PMID:9883737   PMID:10027300   PMID:10340301   PMID:10591208   PMID:10623590   PMID:10839360   PMID:11007882   PMID:11237868   PMID:11278603  
PMID:11343649   PMID:11641419   PMID:11739374   PMID:11802773   PMID:11891216   PMID:12065412   PMID:12138111   PMID:12399460   PMID:12477932   PMID:12508107   PMID:12529303   PMID:12578970  
PMID:12597860   PMID:12826667   PMID:12941441   PMID:14550765   PMID:14702039   PMID:15304526   PMID:15305146   PMID:15458844   PMID:15461802   PMID:15489334   PMID:15811349   PMID:16055064  
PMID:16314870   PMID:16712791   PMID:16713569   PMID:17367885   PMID:17553932   PMID:17606663   PMID:17914463   PMID:18692513   PMID:18755154   PMID:19086053   PMID:19219857   PMID:20018661  
PMID:20384629   PMID:20385472   PMID:20562896   PMID:21653829   PMID:21690291   PMID:21873635   PMID:21949352   PMID:21988832   PMID:22232691   PMID:22275068   PMID:22303009   PMID:22436349  
PMID:22710801   PMID:24358315   PMID:24723684   PMID:24749734   PMID:24937449   PMID:25023278   PMID:25640309   PMID:25657323   PMID:26073603   PMID:26186194   PMID:26466675   PMID:28404816  
PMID:28507309   PMID:28514442   PMID:28697177   PMID:28855251   PMID:29471107   PMID:29743604   PMID:29768204   PMID:29987020   PMID:30419043   PMID:30561431   PMID:31740529   PMID:32296183  
PMID:32814053  


Genomics

Comparative Map Data
PICK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2238,056,311 - 38,075,701 (+)EnsemblGRCh38hg38GRCh38
GRCh382238,056,311 - 38,075,704 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,453,262 - 38,471,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,783,208 - 36,801,654 (+)NCBINCBI36hg18NCBI36
Build 342236,777,902 - 36,796,207NCBI
Celera2222,255,002 - 22,273,457 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,417,897 - 21,436,386 (+)NCBIHuRef
CHM1_12238,411,992 - 38,430,442 (+)NCBICHM1_1
Pick1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,113,373 - 79,133,666 (+)NCBIGRCm39mm39
GRCm39 Ensembl1579,113,373 - 79,133,684 (+)Ensembl
GRCm381579,229,140 - 79,249,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,229,173 - 79,249,484 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,059,604 - 79,079,896 (+)NCBIGRCm37mm9NCBIm37
MGSCv361579,057,068 - 79,076,715 (+)NCBImm8
Celera1581,348,804 - 81,369,231 (+)NCBICelera
Cytogenetic Map15E1NCBI
Pick1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27110,796,623 - 110,816,850 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7110,797,117 - 110,816,848 (+)Ensembl
Rnor_6.07120,465,472 - 120,484,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,465,130 - 120,484,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,459,118 - 120,478,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,213,299 - 117,232,651 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17117,247,528 - 117,266,879 (+)NCBI
Celera7107,131,151 - 107,150,407 (+)NCBICelera
Cytogenetic Map7q34NCBI
Pick1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,383,130 - 24,399,196 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,383,130 - 24,399,092 (+)NCBIChiLan1.0ChiLan1.0
LOC100972387
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12236,796,053 - 36,814,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,796,015 - 36,814,469 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02218,868,872 - 18,988,918 (+)NCBIMhudiblu_PPA_v0panPan3
PICK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,595,301 - 26,614,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,595,768 - 26,613,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,550,611 - 26,569,400 (-)NCBI
ROS_Cfam_1.01027,387,103 - 27,406,123 (-)NCBI
UMICH_Zoey_3.11027,107,123 - 27,126,143 (-)NCBI
UNSW_CanFamBas_1.01027,418,687 - 27,437,706 (-)NCBI
UU_Cfam_GSD_1.01027,595,780 - 27,614,797 (-)NCBI
Pick1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,087,798 - 10,105,588 (-)NCBI
SpeTri2.0NW_0049364923,098,196 - 3,115,921 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PICK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,808,450 - 9,889,930 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,808,444 - 9,829,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,208,317 - 7,225,652 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PICK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,758,199 - 20,778,210 (+)NCBI
ChlSab1.1 Ensembl1920,759,960 - 20,779,514 (+)Ensembl
Vero_WHO_p1.0NW_023666045104,992,571 - 105,011,487 (-)NCBI
Pick1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247529,880,773 - 9,895,270 (-)NCBI

Position Markers
G18158  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372238,456,569 - 38,456,709UniSTSGRCh37
Build 362236,786,515 - 36,786,655RGDNCBI36
Celera2222,258,311 - 22,258,451RGD
Cytogenetic Map22q13.1UniSTS
HuRef2221,421,206 - 21,421,346UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4827
Count of miRNA genes:1046
Interacting mature miRNAs:1337
Transcripts:ENST00000356976, ENST00000404072, ENST00000424694, ENST00000426258, ENST00000432756, ENST00000435166, ENST00000437453, ENST00000445628, ENST00000466374, ENST00000468288, ENST00000469819, ENST00000472724, ENST00000476157, ENST00000484021, ENST00000494434
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2379 2400 1581 491 1129 332 4297 2002 3456 347 1425 1560 173 1 1178 2772 5 2
Low 60 591 145 133 817 133 60 194 278 72 34 52 2 26 16 1
Below cutoff 3 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001039584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006724379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006724380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011530517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002958727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB026491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF231710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB141073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN482899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000356976   ⟹   ENSP00000349465
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,404 - 38,075,701 (+)Ensembl
RefSeq Acc Id: ENST00000404072   ⟹   ENSP00000385205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,200 - 38,075,701 (+)Ensembl
RefSeq Acc Id: ENST00000424694   ⟹   ENSP00000398141
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,228 - 38,072,608 (+)Ensembl
RefSeq Acc Id: ENST00000426258   ⟹   ENSP00000413962
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,404 - 38,070,891 (+)Ensembl
RefSeq Acc Id: ENST00000432756   ⟹   ENSP00000387861
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,656 - 38,071,728 (+)Ensembl
RefSeq Acc Id: ENST00000435166   ⟹   ENSP00000397588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,653 - 38,069,085 (+)Ensembl
RefSeq Acc Id: ENST00000437453   ⟹   ENSP00000410793
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,395 - 38,068,114 (+)Ensembl
RefSeq Acc Id: ENST00000445628   ⟹   ENSP00000416487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,056,311 - 38,059,306 (+)Ensembl
RefSeq Acc Id: ENST00000466374
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,483 - 38,068,085 (+)Ensembl
RefSeq Acc Id: ENST00000468288
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,404 - 38,070,891 (+)Ensembl
RefSeq Acc Id: ENST00000469819
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,407 - 38,065,226 (+)Ensembl
RefSeq Acc Id: ENST00000472724
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,065,113 - 38,072,007 (+)Ensembl
RefSeq Acc Id: ENST00000476157
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,404 - 38,058,158 (+)Ensembl
RefSeq Acc Id: ENST00000484021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,057,255 - 38,075,693 (+)Ensembl
RefSeq Acc Id: ENST00000494434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2238,067,477 - 38,072,534 (+)Ensembl
RefSeq Acc Id: NM_001039583   ⟹   NP_001034672
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,255 - 38,075,701 (+)NCBI
GRCh372238,453,262 - 38,471,708 (+)ENTREZGENE
Build 362236,783,208 - 36,801,654 (+)NCBI Archive
HuRef2221,417,897 - 21,436,386 (+)ENTREZGENE
CHM1_12238,411,992 - 38,430,442 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001039584   ⟹   NP_001034673
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,255 - 38,075,701 (+)NCBI
GRCh372238,453,262 - 38,471,708 (+)ENTREZGENE
Build 362236,783,208 - 36,801,654 (+)NCBI Archive
HuRef2221,417,897 - 21,436,386 (+)ENTREZGENE
CHM1_12238,411,992 - 38,430,442 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012407   ⟹   NP_036539
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,404 - 38,075,701 (+)NCBI
GRCh372238,453,262 - 38,471,708 (+)ENTREZGENE
Build 362236,783,208 - 36,801,654 (+)NCBI Archive
HuRef2221,417,897 - 21,436,386 (+)ENTREZGENE
CHM1_12238,411,992 - 38,430,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006724379   ⟹   XP_006724442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,402 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006724380   ⟹   XP_006724443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,385 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011530517   ⟹   XP_011528819
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,396 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017029090   ⟹   XP_016884579
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,417 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017029091   ⟹   XP_016884580
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,056,311 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017029092   ⟹   XP_016884581
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,829 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017029093   ⟹   XP_016884582
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,404 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017029094   ⟹   XP_016884583
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,056,334 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958723
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,396 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958724
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,402 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958725
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,402 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958726
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,056,311 - 38,075,704 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002958727
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,056,311 - 38,075,704 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001034672 (Get FASTA)   NCBI Sequence Viewer  
  NP_001034673 (Get FASTA)   NCBI Sequence Viewer  
  NP_036539 (Get FASTA)   NCBI Sequence Viewer  
  XP_006724442 (Get FASTA)   NCBI Sequence Viewer  
  XP_006724443 (Get FASTA)   NCBI Sequence Viewer  
  XP_011528819 (Get FASTA)   NCBI Sequence Viewer  
  XP_016884579 (Get FASTA)   NCBI Sequence Viewer  
  XP_016884580 (Get FASTA)   NCBI Sequence Viewer  
  XP_016884581 (Get FASTA)   NCBI Sequence Viewer  
  XP_016884582 (Get FASTA)   NCBI Sequence Viewer  
  XP_016884583 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF97502 (Get FASTA)   NCBI Sequence Viewer  
  AAH17561 (Get FASTA)   NCBI Sequence Viewer  
  BAA89294 (Get FASTA)   NCBI Sequence Viewer  
  BAD96360 (Get FASTA)   NCBI Sequence Viewer  
  BAG50834 (Get FASTA)   NCBI Sequence Viewer  
  BAG52614 (Get FASTA)   NCBI Sequence Viewer  
  BAG61591 (Get FASTA)   NCBI Sequence Viewer  
  CAB41082 (Get FASTA)   NCBI Sequence Viewer  
  CAG30436 (Get FASTA)   NCBI Sequence Viewer  
  EAW60207 (Get FASTA)   NCBI Sequence Viewer  
  EAW60208 (Get FASTA)   NCBI Sequence Viewer  
  EAW60209 (Get FASTA)   NCBI Sequence Viewer  
  EAW60210 (Get FASTA)   NCBI Sequence Viewer  
  EAW60211 (Get FASTA)   NCBI Sequence Viewer  
  EAW60212 (Get FASTA)   NCBI Sequence Viewer  
  EAW60213 (Get FASTA)   NCBI Sequence Viewer  
  Q9NRD5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036539   ⟸   NM_012407
- UniProtKB: Q9NRD5 (UniProtKB/Swiss-Prot),   A0A024R1J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001034672   ⟸   NM_001039583
- UniProtKB: Q9NRD5 (UniProtKB/Swiss-Prot),   A0A024R1J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001034673   ⟸   NM_001039584
- UniProtKB: Q9NRD5 (UniProtKB/Swiss-Prot),   A0A024R1J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006724443   ⟸   XM_006724380
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006724442   ⟸   XM_006724379
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011528819   ⟸   XM_011530517
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016884580   ⟸   XM_017029091
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016884583   ⟸   XM_017029094
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016884582   ⟸   XM_017029093
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016884579   ⟸   XM_017029090
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016884581   ⟸   XM_017029092
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000398141   ⟸   ENST00000424694
RefSeq Acc Id: ENSP00000413962   ⟸   ENST00000426258
RefSeq Acc Id: ENSP00000385205   ⟸   ENST00000404072
RefSeq Acc Id: ENSP00000416487   ⟸   ENST00000445628
RefSeq Acc Id: ENSP00000387861   ⟸   ENST00000432756
RefSeq Acc Id: ENSP00000349465   ⟸   ENST00000356976
RefSeq Acc Id: ENSP00000397588   ⟸   ENST00000435166
RefSeq Acc Id: ENSP00000410793   ⟸   ENST00000437453
Protein Domains
AH   PDZ

Promoters
RGD ID:6800218
Promoter ID:HG_KWN:42764
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:NM_001039584,   NM_012407,   OTTHUMT00000321569,   OTTHUMT00000321609,   OTTHUMT00000321611,   OTTHUMT00000321612,   OTTHUMT00000321613,   OTTHUMT00000321614,   OTTHUMT00000321615,   OTTHUMT00000321616,   OTTHUMT00000321617,   OTTHUMT00000321618,   OTTHUMT00000321619,   OTTHUMT00000321622,   OTTHUMT00000321623,   UC003AUT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362236,782,959 - 36,783,459 (+)MPROMDB
RGD ID:6850784
Promoter ID:EP73186
Type:multiple initiation site
Name:HS_PRKCABP
Description:Protein kinase C, alpha binding protein.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362236,783,360 - 36,783,420EPD
RGD ID:13604028
Promoter ID:EPDNEW_H28198
Type:initiation region
Name:PICK1_1
Description:protein interacting with PRKCA 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382238,057,404 - 38,057,464EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q12.3-13.1(chr22:35333993-38900177)x1 copy number loss See cases [RCV000051364] Chr22:35333993..38900177 [GRCh38]
Chr22:35729986..39296182 [GRCh37]
Chr22:34059986..37626128 [NCBI36]
Chr22:22q12.3-13.1
pathogenic
GRCh38/hg38 22q12.3-13.1(chr22:36859030-39236985)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051366]|See cases [RCV000051366] Chr22:36859030..39236985 [GRCh38]
Chr22:37255072..39632990 [GRCh37]
Chr22:35585018..37962936 [NCBI36]
Chr22:22q12.3-13.1
pathogenic
GRCh38/hg38 22q13.1(chr22:37721777-38886664)x1 copy number loss See cases [RCV000051367] Chr22:37721777..38886664 [GRCh38]
Chr22:38117784..39282669 [GRCh37]
Chr22:36447730..37612615 [NCBI36]
Chr22:22q13.1
pathogenic
GRCh38/hg38 22q13.1(chr22:37994092-38066784)x1 copy number loss See cases [RCV000051368] Chr22:37994092..38066784 [GRCh38]
Chr22:38390099..38462791 [GRCh37]
Chr22:36720045..36792737 [NCBI36]
Chr22:22q13.1
pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:37061769-50738932)x3 copy number gain See cases [RCV000051684] Chr22:37061769..50738932 [GRCh38]
Chr22:37457809..51177360 [GRCh37]
Chr22:35787755..49524226 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q13.1-13.2(chr22:37721797-40860953)x3 copy number gain See cases [RCV000051685] Chr22:37721797..40860953 [GRCh38]
Chr22:38117804..41256957 [GRCh37]
Chr22:36447750..39586903 [NCBI36]
Chr22:22q13.1-13.2
pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q13.1(chr22:37447222-39103680)x1 copy number loss See cases [RCV000141783] Chr22:37447222..39103680 [GRCh38]
Chr22:37843259..39499685 [GRCh37]
Chr22:36173205..37829631 [NCBI36]
Chr22:22q13.1
pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:37090025-39601950)x3 copy number gain See cases [RCV000446037] Chr22:37090025..39601950 [GRCh37]
Chr22:22q12.3-13.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3 copy number gain See cases [RCV000240469] Chr22:35728929..51220961 [GRCh37]
Chr22:22q12.3-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q13.1(chr22:38322968-38965458) copy number gain See cases [RCV000447478] Chr22:38322968..38965458 [GRCh37]
Chr22:22q13.1
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q13.1(chr22:37866631-39054815)x1 copy number loss See cases [RCV000511673] Chr22:37866631..39054815 [GRCh37]
Chr22:22q13.1
pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:36877226-38548989)x1 copy number loss See cases [RCV000512008] Chr22:36877226..38548989 [GRCh37]
Chr22:22q12.3-13.1
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:35674826-39466442)x3 copy number gain See cases [RCV000512385] Chr22:35674826..39466442 [GRCh37]
Chr22:22q12.3-13.1
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_012407.4(PICK1):c.1047C>T (p.Tyr349=) single nucleotide variant not provided [RCV000884348] Chr22:38074931 [GRCh38]
Chr22:38470938 [GRCh37]
Chr22:22q13.1
benign
GRCh37/hg19 22q13.1(chr22:38431917-39392250)x1 copy number loss See cases [RCV001007404] Chr22:38431917..39392250 [GRCh37]
Chr22:22q13.1
likely pathogenic
GRCh37/hg19 22q13.1(chr22:38002218-38973070)x1 copy number loss not provided [RCV001007501] Chr22:38002218..38973070 [GRCh37]
Chr22:22q13.1
pathogenic
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_012407.4(PICK1):c.350-6G>A single nucleotide variant not provided [RCV000888266] Chr22:38069027 [GRCh38]
Chr22:38465034 [GRCh37]
Chr22:22q13.1
benign
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q13.1(chr22:38155164-38541997) copy number loss Waardenburg syndrome type 2E [RCV001290182] Chr22:38155164..38541997 [GRCh37]
Chr22:22q13.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9394 AgrOrtholog
COSMIC PICK1 COSMIC
Ensembl Genes ENSG00000100151 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000349465 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387861 UniProtKB/TrEMBL
  ENSP00000397588 UniProtKB/TrEMBL
  ENSP00000398141 UniProtKB/TrEMBL
  ENSP00000410793 UniProtKB/TrEMBL
  ENSP00000413962 UniProtKB/TrEMBL
  ENSP00000416487 UniProtKB/TrEMBL
Ensembl Transcript ENST00000356976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000404072 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000424694 UniProtKB/TrEMBL
  ENST00000426258 UniProtKB/TrEMBL
  ENST00000432756 UniProtKB/TrEMBL
  ENST00000435166 UniProtKB/TrEMBL
  ENST00000437453 UniProtKB/TrEMBL
  ENST00000445628 UniProtKB/TrEMBL
  ENST00000484021 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000100151 GTEx
HGNC ID HGNC:9394 ENTREZGENE
Human Proteome Map PICK1 Human Proteome Map
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arfaptin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PICK1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9463 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9463 ENTREZGENE
OMIM 605926 OMIM
PANTHER PTHR12141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arfaptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33760 PharmGKB
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Arfaptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R1J5 ENTREZGENE, UniProtKB/TrEMBL
  A0A024R1R7_HUMAN UniProtKB/TrEMBL
  E7EX80_HUMAN UniProtKB/TrEMBL
  F6TII1_HUMAN UniProtKB/TrEMBL
  F6V107_HUMAN UniProtKB/TrEMBL
  F6V3V1_HUMAN UniProtKB/TrEMBL
  F6VY12_HUMAN UniProtKB/TrEMBL
  PICK1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B3KS52 UniProtKB/Swiss-Prot
  F2Z3P1 UniProtKB/TrEMBL
  O95906 UniProtKB/Swiss-Prot