Gene: GRM2 (glutamate metabotropic receptor 2) Homo sapiens
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Symbol:
GRM2
Name:
glutamate metabotropic receptor 2
Description:
Predicted to have calcium channel regulator activity and group II metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to localize to the integral component of plasma membrane.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
GLUR2; glutamate receptor homolog; glutamate receptor, metabotropic 2; GPRC1B; metabotropic glutamate receptor 2; mGlu2; MGLUR2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Grm2 (glutamate receptor, metabotropic 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Grm2 (glutamate metabotropic receptor 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Grm2 (glutamate metabotropic receptor 2) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
GRM2 (glutamate metabotropic receptor 2) NCBI
Ortholog
Canis lupus familiaris (dog):
GRM2 (glutamate metabotropic receptor 2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Grm2 (glutamate metabotropic receptor 2) NCBI
Ortholog
Sus scrofa (pig):
GRM2 (glutamate metabotropic receptor 2) HGNC
Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
Grm1 (glutamate metabotropic receptor 1) HGNC
OrthoMCL
Rattus norvegicus (Norway rat):
Grm3 (glutamate metabotropic receptor 3) HGNC
OrthoMCL
Rattus norvegicus (Norway rat):
Grm5 (glutamate metabotropic receptor 5) HGNC
OrthoMCL
Rattus norvegicus (Norway rat):
Grm6 (glutamate metabotropic receptor 6) HGNC
OrthoMCL
Rattus norvegicus (Norway rat):
Grm8 (glutamate metabotropic receptor 8) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm8 (glutamate receptor, metabotropic 8) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm1 (glutamate receptor, metabotropic 1) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm5 (glutamate receptor, metabotropic 5) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm6 (glutamate receptor, metabotropic 6) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm3 (glutamate receptor, metabotropic 3) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm4 (glutamate receptor, metabotropic 4) HGNC
OrthoMCL
Mus musculus (house mouse):
Grm7 (glutamate receptor, metabotropic 7) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Grm2 (glutamate metabotropic receptor 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Grm2 (glutamate receptor, metabotropic 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
grm2b (glutamate receptor, metabotropic 2b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
grm2a (glutamate receptor, metabotropic 2a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
mGluR
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
mgl-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 51,707,068 - 51,718,616 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 3 51,741,081 - 51,752,629 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 51,718,004 - 51,727,669 (+) NCBI NCBI36 hg18 NCBI36 Build 34 3 51,718,037 - 51,727,168 NCBI Celera 3 51,718,848 - 51,731,506 (+) NCBI Cytogenetic Map 3 p21.2 NCBI HuRef 3 51,802,839 - 51,816,142 (+) NCBI HuRef CHM1_1 3 51,693,893 - 51,705,447 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-pilocarpine decreases expression ISO RGD:2743 6480464 Pilocarpine results in decreased expression of GRM2 mRNA, Pilocarpine results in decreased expression of GRM2 protein CTD PMID:16793029 more ... 17beta-estradiol increases activity ISO RGD:2743 6480464 Estradiol results in increased activity of GRM2 protein CTD PMID:15901789 2,3,7,8-tetrachlorodibenzodioxine increases methylation ISO RGD:1557983 6480464 Tetrachlorodibenzodioxin results in increased methylation of GRM2 gene CTD PMID:21212295 4,4'-sulfonyldiphenol decreases expression ISO RGD:1557983 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of GRM2 mRNA CTD PMID:30951980 4-amino-2,6-dinitrotoluene affects expression ISO RGD:2743 6480464 4-amino-2, 6-dinitrotoluene affects the expression of GRM2 mRNA CTD PMID:21346803 6-propyl-2-thiouracil decreases expression ISO RGD:2743 6480464 Propylthiouracil results in decreased expression of GRM2 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of GRM2 mRNA CTD PMID:22100608 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of GRM2 mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:2743 6480464 Ammonium Chloride affects the expression of GRM2 mRNA CTD PMID:16483693 arsane affects methylation EXP 6480464 Arsenic affects the methylation of GRM2 gene CTD PMID:25304211 arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of GRM2 gene CTD PMID:25304211 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:2743 6480464 Diethylhexyl Phthalate results in decreased expression of GRM2 mRNA CTD PMID:15620428 bisphenol A decreases expression ISO RGD:2743 6480464 bisphenol A results in decreased expression of GRM2 mRNA CTD PMID:25181051 , PMID:25812946 bisphenol A decreases expression ISO RGD:1557983 6480464 bisphenol A results in decreased expression of GRM2 mRNA CTD PMID:30951980 bisphenol F decreases expression ISO RGD:1557983 6480464 bisphenol F results in decreased expression of GRM2 mRNA CTD PMID:30951980 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of GRM2 mRNA CTD PMID:25979313 chlorpyrifos increases expression ISO RGD:2743 6480464 Chlorpyrifos results in increased expression of GRM2 mRNA CTD PMID:17452286 cocaine increases activity ISO RGD:2743 6480464 Cocaine results in increased activity of GRM2 protein CTD PMID:20416862 cocaine affects expression ISO RGD:2743 6480464 Cocaine affects the expression of GRM2 protein CTD PMID:19105975 cocaine decreases activity ISO RGD:2743 6480464 Cocaine results in decreased activity of GRM2 protein CTD PMID:18673447 curcumin decreases expression ISO RGD:1557983 6480464 Curcumin results in decreased expression of GRM2 protein CTD PMID:25406541 diazinon increases expression ISO RGD:2743 6480464 Diazinon results in increased expression of GRM2 mRNA CTD PMID:17452286 entinostat decreases expression EXP 6480464 entinostat results in decreased expression of GRM2 mRNA CTD PMID:27188386 ethanol affects expression ISO RGD:1557983 6480464 Ethanol affects the expression of GRM2 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1557983 6480464 Ethanol results in increased expression of GRM2 mRNA CTD PMID:30319688 fonofos increases methylation EXP 6480464 Fonofos results in increased methylation of GRM2 promoter CTD PMID:22847954 haloperidol increases expression ISO RGD:2743 6480464 Haloperidol results in increased expression of GRM2 mRNA CTD PMID:18923069 mescaline multiple interactions ISO RGD:1557983 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Mescaline CTD PMID:21366332 methamphetamine increases response to substance EXP 6480464 GRM2 gene SNP results in increased susceptibility to Methamphetamine CTD PMID:20211215 methamphetamine multiple interactions ISO RGD:1557983 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Methamphetamine CTD PMID:21366332 N-acetyl-L-cysteine increases activity EXP 6480464 Acetylcysteine results in increased activity of GRM2 protein CTD PMID:19136971 Nonylphenol decreases expression ISO RGD:2743 6480464 nonylphenol results in decreased expression of GRM2 mRNA CTD PMID:15620428 paraquat affects expression ISO RGD:2743 6480464 Paraquat affects the expression of GRM2 mRNA CTD PMID:15206577 parathion increases methylation EXP 6480464 Parathion results in increased methylation of GRM2 promoter CTD PMID:22847954 piperidines multiple interactions ISO RGD:1557983 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Mescaline, [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Methamphetamine CTD PMID:21366332 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of GRM2 mRNA CTD PMID:29955902 sodium arsenite decreases expression ISO RGD:1557983 6480464 sodium arsenite results in decreased expression of GRM2 protein CTD PMID:29748927 Soman decreases expression ISO RGD:2743 6480464 Soman results in decreased expression of GRM2 mRNA CTD PMID:19281266 terbufos increases methylation EXP 6480464 terbufos results in increased methylation of GRM2 promoter CTD PMID:22847954 titanium dioxide decreases expression ISO RGD:1557983 6480464 titanium dioxide results in decreased expression of GRM2 mRNA, titanium dioxide results in decreased expression of GRM2 protein CTD PMID:25411160 triclosan increases expression EXP 6480464 Triclosan results in increased expression of GRM2 mRNA CTD PMID:30510588 tunicamycin increases expression ISO RGD:1557983 6480464 Tunicamycin results in increased expression of GRM2 mRNA CTD PMID:17127020 valproic acid affects expression ISO RGD:1557983 6480464 Valproic Acid affects the expression of GRM2 mRNA CTD PMID:17963808 
Gene-Chemical Interaction Annotations
