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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:erastin
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Accession:CHEBI:94287 term browser browse the term
Definition:A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Synonyms:exact_synonym: 2-(1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
 related_synonym: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone;   Formula=C30H31ClN4O4;   InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3;   InChIKey=BKQFRNYHFIQEKN-UHFFFAOYSA-N;   SMILES=CCOC1=CC=CC=C1N1C(=O)C2=CC=CC=C2N=C1C(C)N1CCN(CC1)C(=O)COC1=CC=C(Cl)C=C1
 xref: CAS:571203-78-6;   Chemspider:9390002;   KEGG:C21478;   LINCS:LSM-4914
 xref_mesh: MESH:C477224
 xref: PMID:12676586;   PMID:17568748;   PMID:22832321;   PMID:26231156;   PMID:30522056;   PMID:31273299;   PMID:31464035;   PMID:31921655;   PMID:31974380;   PMID:31997820;   PMID:32089268;   PMID:32209255;   PMID:32606760;   PMID:32608563;   PMID:32642794;   PMID:32793311;   PMID:32893325;   PMID:32945484;   PMID:32979793;   PMID:33245979;   PMID:33333051;   PMID:33378529;   PMID:33609745;   PMID:33649848;   PMID:33675143;   PMID:33681481;   PMID:33864570;   PMID:33882617;   PMID:34012798;   Wikipedia:Erastin


show annotations for term's descendants           Sort by:
erastin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acrbp acrosin binding protein increases expression ISO erastin results in increased expression of ACRBP mRNA alternative form CTD PMID:35234341 NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression
multiple interactions 		ISO erastin results in increased expression of ACSL4 protein
leonurine inhibits the reaction [erastin results in increased expression of ACSL4 protein] 		CTD PMID:38670420 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance 		ISO AHR protein affects the reaction [[indol-3-yl pyruvic acid co-treated with erastin] results in increased expression of SLC7A11 protein]; AHR protein affects the reaction [erastin results in increased expression of SLC7A11 mRNA]; AHR protein affects the reaction [erastin results in increased expression of SLC7A11 protein]
AHR protein affects the susceptibility to erastin 		CTD PMID:38641223 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor affects response to substance ISO AR protein affects the susceptibility to erastin CTD PMID:39309439 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arid3a AT-rich interaction domain 3A multiple interactions
increases expression 		ISO Doxycycline promotes the reaction [erastin results in increased expression of ARID3A mRNA] CTD PMID:38115220 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression 		ISO leonurine inhibits the reaction [erastin results in increased expression of ATF4 protein] CTD PMID:38670420 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atg5 autophagy related 5 increases expression EXP erastin results in increased expression of ATG5 protein CTD PMID:32937103 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bgn biglycan multiple interactions
decreases expression 		ISO BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form]
erastin results in decreased expression of BGN mRNA alternative form 		CTD PMID:35234341 NCBI chr  X:156,348,633...156,360,797
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage 		ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [erastin results in increased cleavage of CASP3 protein] CTD PMID:38641223 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression
multiple interactions 		ISO erastin results in increased expression of CEBPD mRNA
Doxycycline promotes the reaction [erastin results in increased expression of CEBPD mRNA] 		CTD PMID:38115220 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression 		ISO GW 506033X inhibits the reaction [erastin results in increased expression of CHAC1 mRNA]
leonurine inhibits the reaction [erastin results in increased expression of CHAC1 protein] 		CTD PMID:30817950 PMID:38670420 NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 increases expression
multiple interactions 		ISO erastin results in increased expression of CHST4 mRNA
Doxycycline promotes the reaction [erastin results in increased expression of CHST4 mRNA] 		CTD PMID:38115220 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of CITED2 mRNA CTD PMID:38115220 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO erastin results in increased expression of COL1A2 mRNA alternative form CTD PMID:35234341 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol] CTD PMID:33017621 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO erastin promotes the reaction [Silicon Dioxide results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [erastin results in increased expression of DDIT3 mRNA]
leonurine inhibits the reaction [erastin results in increased expression of DDIT3 protein] 		CTD PMID:30817950 PMID:37075931 PMID:38670420 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression ISO erastin results in increased expression of DTL mRNA alternative form CTD PMID:35234341 NCBI chr13:105,646,908...105,685,921
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO erastin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein; leonurine inhibits the reaction [erastin results in increased expression of EIF2AK3 protein] CTD PMID:38670420 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO erastin results in increased expression of and results in increased phosphorylation of EIF2S1 protein; leonurine inhibits the reaction [erastin results in increased expression of and results in increased phosphorylation of EIF2S1 protein] CTD PMID:38670420 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation 		ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of ERN1 protein] CTD PMID:30817950 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fancd2 FA complementation group D2 decreases expression EXP erastin results in decreased expression of FANCD2 protein CTD PMID:32937103 NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fasn fatty acid synthase affects response to substance
decreases expression 		ISO FASN protein affects the susceptibility to erastin
erastin results in decreased expression of FASN protein 		CTD PMID:39309439 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fh fumarate hydratase decreases response to substance ISO FH protein results in decreased susceptibility to erastin CTD PMID:29917289 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression 		EXP
ISO 		3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]; Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]
[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein] 		CTD PMID:32937103 PMID:37951334 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein] CTD PMID:37951334 NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression
multiple interactions 		ISO erastin results in increased expression of GABARAPL1 mRNA
Doxycycline promotes the reaction [erastin results in increased expression of GABARAPL1 mRNA] 		CTD PMID:38115220 NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression 		EXP NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] CTD PMID:32937103 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions 		EXP erastin results in increased expression of GCLM protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein] 		CTD PMID:32937103 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein] CTD PMID:34785303 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions 		ISO
EXP 		erastin results in decreased expression of GPX4 protein
astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [erastin results in decreased expression of GPX4 protein]; gap 27 peptide inhibits the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein]
erastin promotes the reaction [Silicon Dioxide results in decreased expression of GPX4 protein] 		CTD PMID:31323261 PMID:32937103 PMID:34785303 PMID:37075931 PMID:37648051 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression 		ISO cordycepin inhibits the reaction [erastin results in increased expression of GSK3B protein] CTD PMID:38014886 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]] CTD PMID:39053875 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions
increases expression 		ISO Doxycycline promotes the reaction [erastin results in increased expression of HMGA2 mRNA] CTD PMID:38115220 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
increases response to substance 		ISO erastin results in increased expression of HMOX1 protein
erastin results in increased expression of HMOX1 mRNA; erastin results in increased expression of HMOX1 protein
Doxycycline promotes the reaction [erastin results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased susceptibility to erastin 		CTD PMID:30817950 PMID:38115220 PMID:38641223 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance ISO HRAS protein modified form results in increased susceptibility to erastin CTD PMID:17568748 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO erastin results in increased expression of HSPA5 protein
erastin promotes the reaction [Silicon Dioxide results in increased expression of HSPA5 protein] 		CTD PMID:37075931 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases phosphorylation EXP erastin results in decreased phosphorylation of HSPB1 protein CTD PMID:32937103 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]] CTD PMID:39053875 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of IL6 mRNA]] CTD PMID:39053875 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Krt5 keratin 5 multiple interactions
increases expression 		ISO Doxycycline promotes the reaction [erastin results in increased expression of KRT5 mRNA] CTD PMID:38115220 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions 		EXP erastin results in increased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form] 		CTD PMID:32937103 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO erastin results in increased phosphorylation of MAPK1 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK1 protein] 		CTD PMID:30817950 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK3 protein] CTD PMID:30817950 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions 		ISO erastin results in increased phosphorylation of MAPK8 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK8 protein] 		CTD PMID:30817950 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mb myoglobin multiple interactions
increases expression
increases response to substance 		ISO Doxycycline promotes the reaction [erastin results in increased expression of MB mRNA]
MB protein results in increased susceptibility to erastin 		CTD PMID:38115220 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions 		ISO erastin results in decreased expression of MKI67 protein
BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]
Butyric Acid promotes the reaction [erastin results in decreased expression of MKI67 protein] 		CTD PMID:35234341 PMID:37341073 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Msh2 mutS homolog 2 increases expression ISO erastin results in increased expression of MSH2 mRNA alternative form CTD PMID:35234341 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 decreases expression
multiple interactions 		EXP
ISO 		erastin results in decreased expression of NCOA4 protein
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]; Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein] 		CTD PMID:32937103 PMID:37951334 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO erastin promotes the reaction [Silicon Dioxide results in increased expression of NFATC2 protein] CTD PMID:37075931 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
decreases expression
affects response to substance 		ISO
EXP 		NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
erastin results in increased expression of NFE2L2 protein
cordycepin inhibits the reaction [erastin results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
NFE2L2 protein affects the susceptibility to erastin 		CTD PMID:31323261 PMID:32937103 PMID:38014886 PMID:38636790 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ntn1 netrin 1 multiple interactions ISO erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of NTN1 mRNA]] CTD PMID:39053875 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions 		ISO erastin results in increased cleavage of PARP1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [erastin results in increased cleavage of PARP1 protein] 		CTD PMID:38641223 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkd2 protein kinase D2 affects response to substance
multiple interactions 		ISO PRKD2 protein affects the susceptibility to erastin
[PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1] 		CTD PMID:37951334 NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases expression 		EXP
ISO 		erastin results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 protein
erastin analog results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 mRNA
Vitamin E inhibits the reaction [erastin analog results in increased expression of PTGS2 mRNA]
erastin results in decreased expression of PTGS2 protein
Quercetin inhibits the reaction [erastin results in increased expression of PTGS2 protein]; Quercetin promotes the reaction [erastin results in decreased expression of PTGS2 protein] 		CTD PMID:24439385 PMID:32937103 PMID:37230155 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rnasel ribonuclease L increases expression
multiple interactions 		ISO erastin results in increased expression of RNASEL mRNA
Doxycycline promotes the reaction [erastin results in increased expression of RNASEL mRNA] 		CTD PMID:38115220 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Rnf38 ring finger protein 38 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of RNF38 mRNA CTD PMID:38115220 NCBI chr 5:63,154,507...63,263,138
Ensembl chr 5:58,361,976...58,467,446 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO erastin results in increased expression of SC5D mRNA alternative form CTD PMID:35234341 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] CTD PMID:31323261 NCBI chr20:46,876,918...46,970,010
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression 		ISO NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of SESN2 mRNA; erastin results in increased expression of SESN2 protein
Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein]; Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA]; Deferoxamine inhibits the reaction [erastin results in increased expression of SESN2 protein]; diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein]; ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein] 		CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP erastin results in increased expression of SLC11A2 protein CTD PMID:32937103 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
increases expression 		EXP
ISO 		erastin results in decreased expression of SLC40A1 protein
erastin results in increased expression of SLC40A1 protein 		CTD PMID:31323261 PMID:32937103 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions
decreases expression 		EXP
ISO 		erastin results in increased expression of SLC7A11 mRNA
NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[indol-3-yl pyruvic acid co-treated with erastin] results in increased expression of SLC7A11 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [erastin results in increased expression of SLC7A11 protein]; [indol-3-yl pyruvic acid co-treated with erastin] results in increased expression of SLC7A11 protein; AHR protein affects the reaction [[indol-3-yl pyruvic acid co-treated with erastin] results in increased expression of SLC7A11 protein]; AHR protein affects the reaction [erastin results in increased expression of SLC7A11 mRNA]; AHR protein affects the reaction [erastin results in increased expression of SLC7A11 protein]; gap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]
erastin promotes the reaction [Silicon Dioxide results in decreased expression of SLC7A11 protein]
erastin results in increased expression of SLC7A11 mRNA; erastin results in increased expression of SLC7A11 protein 		CTD PMID:32937103 PMID:34785303 PMID:37075931 PMID:38641223 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions
increases expression 		ISO Doxycycline promotes the reaction [erastin results in increased expression of SLPI mRNA] CTD PMID:38115220 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO erastin results in decreased expression of SREBF1 protein CTD PMID:39309439 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A decreases expression ISO erastin results in decreased expression of TAF1A mRNA alternative form CTD PMID:35234341 NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087 		JBrowse link
G Tf transferrin increases expression
multiple interactions 		EXP erastin results in increased expression of TF mRNA; erastin results in increased expression of TF protein
Quercetin inhibits the reaction [erastin results in increased expression of TF mRNA]; Quercetin inhibits the reaction [erastin results in increased expression of TF protein] 		CTD PMID:32937103 PMID:37230155 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor increases expression EXP
ISO 		erastin results in increased expression of TFRC protein CTD PMID:31323261 PMID:32937103 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression ISO erastin results in decreased expression of TIMP1 mRNA alternative form CTD PMID:35234341 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of TNF mRNA]]; erastin inhibits the reaction [Quercetin inhibits the reaction [ochratoxin A results in increased expression of TNF protein]] CTD PMID:39053875 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 affects response to substance ISO TXNRD1 protein affects the susceptibility to erastin CTD PMID:38636790 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 decreases expression
increases degradation
affects binding 		ISO
EXP 		erastin results in decreased expression of VDAC2 protein
erastin results in increased degradation of VDAC2 protein
erastin analog binds to VDAC2 protein 		CTD PMID:17568748 PMID:32937103 NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 increases degradation
affects response to substance
decreases expression 		EXP
ISO 		erastin results in increased degradation of VDAC3 protein
VDAC3 protein affects the susceptibility to erastin
erastin results in decreased expression of VDAC3 protein 		CTD PMID:17568748 PMID:32937103 NCBI chr16:76,137,489...76,153,933
Ensembl chr16:69,435,005...69,451,471 		JBrowse link
G Wdr41 WD repeat domain 41 decreases expression ISO erastin results in decreased expression of WDR41 mRNA alternative form CTD PMID:35234341 NCBI chr 2:26,222,797...26,273,849
Ensembl chr 2:26,224,495...26,273,836 		JBrowse link
G Wnt5a Wnt family member 5A multiple interactions
increases expression 		ISO erastin promotes the reaction [Silicon Dioxide results in increased expression of WNT5A protein]
erastin results in increased expression of WNT5A protein 		CTD PMID:37075931 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          ferroptosis inducer 15995
            erastin 74
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              tertiary carboxamide 862
                                                erastin 74
paths to the root