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G |
Acrbp |
acrosin binding protein |
increases expression |
ISO |
erastin results in increased expression of ACRBP mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213
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G |
Atg5 |
autophagy related 5 |
increases expression |
EXP |
erastin results in increased expression of ATG5 protein |
CTD |
PMID:32937103 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bgn |
biglycan |
multiple interactions decreases expression |
ISO |
BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form] erastin results in decreased expression of BGN mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
multiple interactions increases expression |
ISO |
GW 506033X inhibits the reaction [erastin results in increased expression of CHAC1 mRNA] |
CTD |
PMID:30817950 |
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NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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G |
Col1a2 |
collagen type I alpha 2 chain |
increases expression |
ISO |
erastin results in increased expression of COL1A2 mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol] |
CTD |
PMID:33017621 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
erastin promotes the reaction [Silicon Dioxide results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [erastin results in increased expression of DDIT3 mRNA] |
CTD |
PMID:30817950 PMID:37075931 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dtl |
denticleless E3 ubiquitin protein ligase homolog |
increases expression |
ISO |
erastin results in increased expression of DTL mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases phosphorylation |
ISO |
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:30817950 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Fancd2 |
FA complementation group D2 |
decreases expression |
EXP |
erastin results in decreased expression of FANCD2 protein |
CTD |
PMID:32937103 |
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NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fh |
fumarate hydratase |
decreases response to substance |
ISO |
FH protein results in decreased susceptibility to erastin |
CTD |
PMID:29917289 |
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NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions increases expression |
EXP ISO |
3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]; Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein] [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein] |
CTD |
PMID:32937103 PMID:37951334 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
ISO |
[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein] |
CTD |
PMID:37951334 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
EXP |
NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] |
CTD |
PMID:32937103 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
EXP |
erastin results in increased expression of GCLM protein NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein] |
CTD |
PMID:32937103 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein] |
CTD |
PMID:34785303 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases expression multiple interactions |
ISO EXP |
erastin results in decreased expression of GPX4 protein astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [erastin results in decreased expression of GPX4 protein]; gap 27 peptide inhibits the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] erastin promotes the reaction [Silicon Dioxide results in decreased expression of GPX4 protein] |
CTD |
PMID:31323261 PMID:32937103 PMID:34785303 PMID:37075931 PMID:37648051 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
erastin results in increased expression of HMOX1 protein |
CTD |
PMID:30817950 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hras |
HRas proto-oncogene, GTPase |
increases response to substance |
ISO |
HRAS protein modified form results in increased susceptibility to erastin |
CTD |
PMID:17568748 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
erastin results in increased expression of HSPA5 protein erastin promotes the reaction [Silicon Dioxide results in increased expression of HSPA5 protein] |
CTD |
PMID:37075931 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
decreases phosphorylation |
EXP |
erastin results in decreased phosphorylation of HSPB1 protein |
CTD |
PMID:32937103 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
EXP |
erastin results in increased expression of MAP1LC3B protein modified form 3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:32937103 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
erastin results in increased phosphorylation of MAPK1 protein GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:30817950 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:30817950 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
erastin results in increased phosphorylation of MAPK8 protein GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:30817950 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression multiple interactions |
ISO |
erastin results in decreased expression of MKI67 protein BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein] |
CTD |
PMID:35234341 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Msh2 |
mutS homolog 2 |
increases expression |
ISO |
erastin results in increased expression of MSH2 mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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G |
Ncoa4 |
nuclear receptor coactivator 4 |
decreases expression multiple interactions |
EXP ISO |
erastin results in decreased expression of NCOA4 protein 3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]; Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein] [PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein] |
CTD |
PMID:32937103 PMID:37951334 |
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NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G |
Nfatc2 |
nuclear factor of activated T-cells 2 |
multiple interactions |
ISO |
erastin promotes the reaction [Silicon Dioxide results in increased expression of NFATC2 protein] |
CTD |
PMID:37075931 |
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NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO EXP |
NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein] NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA] erastin results in increased expression of NFE2L2 protein |
CTD |
PMID:31323261 PMID:32937103 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Prkd2 |
protein kinase D2 |
affects response to substance multiple interactions |
ISO |
PRKD2 protein affects the susceptibility to erastin [PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1] |
CTD |
PMID:37951334 |
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NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions decreases expression |
EXP ISO |
erastin results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 protein erastin analog results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 mRNA Vitamin E inhibits the reaction [erastin analog results in increased expression of PTGS2 mRNA] erastin results in decreased expression of PTGS2 protein Quercetin inhibits the reaction [erastin results in increased expression of PTGS2 protein]; Quercetin promotes the reaction [erastin results in decreased expression of PTGS2 protein] |
CTD |
PMID:24439385 PMID:32937103 PMID:37230155 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
ISO |
erastin results in increased expression of SC5D mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Sesn1 |
sestrin 1 |
multiple interactions |
ISO |
SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] |
CTD |
PMID:31323261 |
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NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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G |
Sesn2 |
sestrin 2 |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein] erastin results in increased expression of SESN2 mRNA; erastin results in increased expression of SESN2 protein Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein]; Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA]; Deferoxamine inhibits the reaction [erastin results in increased expression of SESN2 protein]; diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein]; ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein] |
CTD |
PMID:31323261 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Slc11a2 |
solute carrier family 11 member 2 |
increases expression |
EXP |
erastin results in increased expression of SLC11A2 protein |
CTD |
PMID:32937103 |
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NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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G |
Slc40a1 |
solute carrier family 40 member 1 |
decreases expression increases expression |
EXP ISO |
erastin results in decreased expression of SLC40A1 protein erastin results in increased expression of SLC40A1 protein |
CTD |
PMID:31323261 PMID:32937103 |
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NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression multiple interactions decreases expression |
EXP ISO |
erastin results in increased expression of SLC7A11 mRNA NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA] gap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein] erastin promotes the reaction [Silicon Dioxide results in decreased expression of SLC7A11 protein] |
CTD |
PMID:32937103 PMID:34785303 PMID:37075931 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Taf1a |
TATA-box binding protein associated factor, RNA polymerase I subunit A |
decreases expression |
ISO |
erastin results in decreased expression of TAF1A mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087
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G |
Tf |
transferrin |
increases expression multiple interactions |
EXP |
erastin results in increased expression of TF mRNA; erastin results in increased expression of TF protein Quercetin inhibits the reaction [erastin results in increased expression of TF mRNA]; Quercetin inhibits the reaction [erastin results in increased expression of TF protein] |
CTD |
PMID:32937103 PMID:37230155 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tfrc |
transferrin receptor |
increases expression |
EXP ISO |
erastin results in increased expression of TFRC protein |
CTD |
PMID:31323261 PMID:32937103 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
decreases expression |
ISO |
erastin results in decreased expression of TIMP1 mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Vdac2 |
voltage-dependent anion channel 2 |
decreases expression increases degradation affects binding |
ISO EXP |
erastin results in decreased expression of VDAC2 protein erastin results in increased degradation of VDAC2 protein erastin analog binds to VDAC2 protein |
CTD |
PMID:17568748 PMID:32937103 |
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NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
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G |
Vdac3 |
voltage-dependent anion channel 3 |
increases degradation affects response to substance decreases expression |
EXP ISO |
erastin results in increased degradation of VDAC3 protein VDAC3 protein affects the susceptibility to erastin erastin results in decreased expression of VDAC3 protein |
CTD |
PMID:17568748 PMID:32937103 |
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NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471
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G |
Wdr41 |
WD repeat domain 41 |
decreases expression |
ISO |
erastin results in decreased expression of WDR41 mRNA alternative form |
CTD |
PMID:35234341 |
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NCBI chr 2:26,222,797...26,273,849
Ensembl chr 2:26,224,495...26,273,836
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G |
Wnt5a |
Wnt family member 5A |
multiple interactions increases expression |
ISO |
erastin promotes the reaction [Silicon Dioxide results in increased expression of WNT5A protein] erastin results in increased expression of WNT5A protein |
CTD |
PMID:37075931 |
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NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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