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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:erastin
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Accession:CHEBI:94287 term browser browse the term
Definition:A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Synonyms:exact_synonym: 2-(1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
 related_synonym: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone;   Formula=C30H31ClN4O4;   InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3;   InChIKey=BKQFRNYHFIQEKN-UHFFFAOYSA-N;   SMILES=CCOC1=CC=CC=C1N1C(=O)C2=CC=CC=C2N=C1C(C)N1CCN(CC1)C(=O)COC1=CC=C(Cl)C=C1
 xref: CAS:571203-78-6;   Chemspider:9390002;   KEGG:C21478;   LINCS:LSM-4914
 xref_mesh: MESH:C477224
 xref: PMID:12676586;   PMID:17568748;   PMID:22832321;   PMID:26231156;   PMID:30522056;   PMID:31273299;   PMID:31464035;   PMID:31921655;   PMID:31974380;   PMID:31997820;   PMID:32089268;   PMID:32209255;   PMID:32606760;   PMID:32608563;   PMID:32642794;   PMID:32793311;   PMID:32893325;   PMID:32945484;   PMID:32979793;   PMID:33245979;   PMID:33333051;   PMID:33378529;   PMID:33609745;   PMID:33649848;   PMID:33675143;   PMID:33681481;   PMID:33864570;   PMID:33882617;   PMID:34012798;   Wikipedia:Erastin



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erastin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acrbp acrosin binding protein increases expression ISO erastin results in increased expression of ACRBP mRNA alternative form CTD PMID:35234341 NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213
JBrowse link
G Atg5 autophagy related 5 increases expression EXP erastin results in increased expression of ATG5 protein CTD PMID:32937103 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bgn biglycan multiple interactions
decreases expression
ISO BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form]
erastin results in decreased expression of BGN mRNA alternative form
CTD PMID:35234341 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression
ISO GW 506033X inhibits the reaction [erastin results in increased expression of CHAC1 mRNA] CTD PMID:30817950 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO erastin results in increased expression of COL1A2 mRNA alternative form CTD PMID:35234341 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol] CTD PMID:33017621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO GW 506033X inhibits the reaction [erastin results in increased expression of DDIT3 mRNA] CTD PMID:30817950 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression ISO erastin results in increased expression of DTL mRNA alternative form CTD PMID:35234341 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation
ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of ERN1 protein] CTD PMID:30817950 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fancd2 FA complementation group D2 decreases expression EXP erastin results in decreased expression of FANCD2 protein CTD PMID:32937103 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fh fumarate hydratase decreases response to substance ISO FH protein results in decreased susceptibility to erastin CTD PMID:29917289 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
EXP 3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]; Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein] CTD PMID:32937103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] CTD PMID:32937103 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
EXP erastin results in increased expression of GCLM protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]
CTD PMID:32937103 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein] CTD PMID:34785303 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions
ISO
EXP
erastin results in decreased expression of GPX4 protein
gap 27 peptide inhibits the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein]
CTD PMID:31323261 PMID:32937103 PMID:34785303 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO erastin results in increased expression of HMOX1 protein CTD PMID:30817950 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance ISO HRAS protein modified form results in increased susceptibility to erastin CTD PMID:17568748 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases phosphorylation EXP erastin results in decreased phosphorylation of HSPB1 protein CTD PMID:32937103 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
EXP erastin results in increased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]
CTD PMID:32937103 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO erastin results in increased phosphorylation of MAPK1 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK1 protein]
CTD PMID:30817950 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK3 protein] CTD PMID:30817950 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO erastin results in increased phosphorylation of MAPK8 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK8 protein]
CTD PMID:30817950 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions
ISO erastin results in decreased expression of MKI67 protein
BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]
CTD PMID:35234341 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Msh2 mutS homolog 2 increases expression ISO erastin results in increased expression of MSH2 mRNA alternative form CTD PMID:35234341 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 decreases expression
multiple interactions
EXP erastin results in decreased expression of NCOA4 protein
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]; Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
CTD PMID:32937103 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO
EXP
NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
CTD PMID:31323261 PMID:32937103 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP
ISO
erastin results in increased expression of PTGS2 mRNA
Vitamin E inhibits the reaction [erastin analog results in increased expression of PTGS2 mRNA]
erastin analog results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 mRNA
CTD PMID:24439385 PMID:32937103 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO erastin results in increased expression of SC5D mRNA alternative form CTD PMID:35234341 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] CTD PMID:31323261 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of SESN2 mRNA; erastin results in increased expression of SESN2 protein
Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein]; Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA]; Deferoxamine inhibits the reaction [erastin results in increased expression of SESN2 protein]; diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein]; ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP erastin results in increased expression of SLC11A2 protein CTD PMID:32937103 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
increases expression
EXP
ISO
erastin results in decreased expression of SLC40A1 protein
erastin results in increased expression of SLC40A1 protein
CTD PMID:31323261 PMID:32937103 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
decreases expression
multiple interactions
EXP
ISO
erastin results in increased expression of SLC7A11 mRNA
erastin results in decreased expression of SLC7A11 protein
gap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]
NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
CTD PMID:32937103 PMID:34785303 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A decreases expression ISO erastin results in decreased expression of TAF1A mRNA alternative form CTD PMID:35234341 NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087
JBrowse link
G Tf transferrin increases expression EXP erastin results in increased expression of TF protein CTD PMID:32937103 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor increases expression EXP
ISO
erastin results in increased expression of TFRC protein CTD PMID:31323261 PMID:32937103 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression ISO erastin results in decreased expression of TIMP1 mRNA alternative form CTD PMID:35234341 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Vdac2 voltage-dependent anion channel 2 decreases expression
affects binding
increases degradation
ISO
EXP
erastin results in decreased expression of VDAC2 protein
erastin analog binds to VDAC2 protein
erastin results in increased degradation of VDAC2 protein
CTD PMID:17568748 PMID:32937103 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
G Vdac3 voltage-dependent anion channel 3 increases degradation
decreases expression
affects response to substance
EXP
ISO
erastin results in increased degradation of VDAC3 protein
erastin results in decreased expression of VDAC3 protein
VDAC3 protein affects the susceptibility to erastin
CTD PMID:17568748 PMID:32937103 NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471
JBrowse link
G Wdr41 WD repeat domain 41 decreases expression ISO erastin results in decreased expression of WDR41 mRNA alternative form CTD PMID:35234341 NCBI chr 2:26,222,797...26,273,840
Ensembl chr 2:26,224,495...26,273,836
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          ferroptosis inducer 15693
            erastin 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic acid 18409
                                        carboacyl group 17570
                                          univalent carboacyl group 17599
                                            carbamoyl group 17407
                                              carboxamide 17407
                                                tertiary carboxamide 224
                                                  erastin 41
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