Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc7a11
Name: solute carrier family 7 member 11
Acc ID: CHEBI:94287
Term: erastin
Definition: A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Chemical ID: MESH:C477224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc7a11increases expressionEXP 6480464CTDerastin results in increased expression of SLC7A11 mRNAPMID:32937103
Slc7a11multiple interactionsEXP 6480464CTDNFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]PMID:32937103
Slc7a11decreases expressionISOSLC7A11 (Homo sapiens)6480464CTDerastin results in decreased expression of SLC7A11 proteinPMID:34785303
Slc7a11decreases expressionISOSlc7a11 (Mus musculus)6480464CTDerastin results in decreased expression of SLC7A11 proteinPMID:37075931
Slc7a11multiple interactionsISOSLC7A11 (Homo sapiens)6480464CTDgap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]PMID:34785303
Slc7a11multiple interactionsISOSlc7a11 (Mus musculus)6480464CTDerastin promotes the reaction [Silicon Dioxide results in decreased expression of SLC7A11 protein]PMID:37075931
Go Back to source page   Continue to Ontology report