Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	620360
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Nfe2l2
Name:	NFE2 like bZIP transcription factor 2

Acc ID:	CHEBI:94287
Term:	erastin
Definition:	A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Chemical ID:	MESH:C477224

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Nfe2l2	increases expression	EXP		6480464	CTD	erastin results in increased expression of NFE2L2 protein	PMID:32937103
Nfe2l2	multiple interactions	EXP		6480464	CTD	NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]	PMID:32937103
Nfe2l2	multiple interactions	ISO	NFE2L2 (Homo sapiens)	6480464	CTD	NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]	PMID:31323261
Nfe2l2	multiple interactions	ISO	Nfe2l2 (Mus musculus)	6480464	CTD	NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]	PMID:31323261

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