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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nimodipine
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Accession:CHEBI:7575 term browser browse the term
Definition:A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Synonyms:exact_synonym: 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester;   BAY e 9736;   Formula=C21H26N2O7;   InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3;   InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N;   Nimotop;   Periplum;   SMILES=COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C;   isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;   isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;   nimodipino;   nimodipinum
 xref: CAS:66085-59-4;   DrugBank:DB00393;   Drug_Central:1937;   KEGG:C07267;   KEGG:D00438;   LINCS:LSM-1659
 xref_mesh: MESH:D009553
 xref: PMID:12137606;   PMID:16180362;   PMID:17110283;   PMID:21869451;   PMID:22262041;   PMID:22300914;   PMID:8519001;   Patent:DE2117571;   Patent:US3799934;   Reaxys:459792;   Wikipedia:Nimodipine


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nimodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 decreases activity ISO Nimodipine results in decreased activity of ANO1 protein CTD PMID:33872679 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:12383957 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor decreases activity ISO Nimodipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Nimodipine results in increased expression of BAX protein
Nimodipine inhibits the reaction [Sevoflurane results in increased expression of BAX protein]		 CTD PMID:17490525 PMID:33171207 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Nimodipine results in decreased expression of BCL2 protein
Nimodipine inhibits the reaction [Sevoflurane results in decreased expression of BCL2 protein]		 CTD PMID:17490525 PMID:33171207 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] CTD PMID:30776390 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased expression of BIRC5 protein] CTD PMID:33336902 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Nimodipine inhibits the reaction [Potassium results in increased secretion of CALCA protein] CTD PMID:18178321 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein]
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP3 protein modified form]		 CTD PMID:22700542 PMID:30776390 PMID:33171207 PMID:33336902 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP9 protein modified form] CTD PMID:33171207 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein] CTD PMID:16115668 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Nimodipine results in increased activity of CFTR protein]; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein] CTD PMID:33872679 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CGA mRNA] CTD PMID:28731686 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Clu clusterin multiple interactions ISO Nimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]; Nimodipine inhibits the reaction [Zinc results in increased expression of CLU protein] CTD PMID:19288494 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] CTD PMID:27095094 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] CTD PMID:30776390 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CYCS protein] CTD PMID:33171207 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA] CTD PMID:28731686 PMID:35931855 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein] CTD PMID:12186780 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein] CTD PMID:12186780 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Nimodipine inhibits the reaction [Zinc results in increased expression of EGR1 protein] CTD PMID:10428039 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP
ISO		 Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]
Nimodipine results in increased expression of FOS mRNA		 CTD PMID:12730611 PMID:17913375 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of FSHB protein] CTD PMID:28731686 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] CTD PMID:27095094 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein] CTD PMID:36925031 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Nimodipine inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] CTD PMID:16300829 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of LHB protein] CTD PMID:28731686 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein] CTD PMID:16635102 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein] CTD PMID:29149324 PMID:30776390 PMID:33336902 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein] CTD PMID:29149324 PMID:30776390 PMID:33336902 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] CTD PMID:27095094 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nppc natriuretic peptide C multiple interactions EXP Nimodipine inhibits the reaction [NPPC protein results in increased uptake of Calcium] CTD PMID:18222015 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity		 ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nimodipine results in decreased activity of NR1H4 protein
Nimodipine results in increased activity of NR1H4 protein		 CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Nimodipine results in increased activity of NR1I2 protein CTD PMID:21068194 PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein] CTD PMID:36925031 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:29149324 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] CTD PMID:27095094 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of STAR mRNA] CTD PMID:28731686 PMID:35931855 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] CTD PMID:27095094 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein] CTD PMID:30776390 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        solvent 17245
          2-methoxyethanol 378
            2-methoxyethyl ester 56
              nimodipine 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      monocarboxylic acid 18028
                                        fatty acid 16848
                                          fatty acid derivative 8985
                                            fatty alcohol 6132
                                              secondary fatty alcohol 803
                                                propan-2-ol 803
                                                  isopropyl ester 777
                                                    nimodipine 46
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