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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions decreases expression |
ISO |
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA fludioxonil results in decreased expression of ACOX1 mRNA |
CTD |
PMID:33575850 |
|
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acox2 |
acyl-CoA oxidase 2 |
multiple interactions decreases expression |
ISO |
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA; [propiconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA fludioxonil results in decreased expression of ACOX2 mRNA |
CTD |
PMID:33575850 |
|
NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
fludioxonil binds to and results in increased activity of AHR protein |
CTD |
PMID:23436777 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Anxa10 |
annexin A10 |
increases expression |
ISO |
fludioxonil results in increased expression of ANXA10 mRNA |
CTD |
PMID:32194361 |
|
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
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G |
Ar |
androgen receptor |
multiple interactions affects binding |
ISO |
fludioxonil inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; fludioxonil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] fludioxonil binds to AR protein |
CTD |
PMID:21310686 PMID:23436777 PMID:33049310 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arg1 |
arginase 1 |
decreases expression |
ISO |
fludioxonil results in decreased expression of ARG1 mRNA |
CTD |
PMID:32194361 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression decreases expression multiple interactions |
ISO |
fludioxonil results in increased expression of BCL2 mRNA fludioxonil results in decreased expression of BCL2 protein MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein] |
CTD |
PMID:23052036 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO |
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA fludioxonil results in increased expression of CASP3 mRNA |
CTD |
PMID:22880100 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
affects binding |
ISO |
fludioxonil binds to CAT protein |
CTD |
PMID:32278787 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression increases expression |
ISO |
ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein] fludioxonil results in increased expression of CCND1 mRNA; fludioxonil results in increased expression of CCND1 protein |
CTD |
PMID:23052036 PMID:23436777 PMID:27539251 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
increases expression multiple interactions |
ISO |
fludioxonil results in increased expression of CCNE1 protein fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein] |
CTD |
PMID:27539251 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdh1 |
cadherin 1 |
decreases expression multiple interactions |
ISO |
fludioxonil results in decreased expression of CDH1 protein [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in decreased expression of CDH1 protein; Fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein] |
CTD |
PMID:27539251 PMID:34503147 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein] |
CTD |
PMID:27539251 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions decreases expression |
ISO |
fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDKN1A protein] |
CTD |
PMID:27539251 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ctsd |
cathepsin D |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein] |
CTD |
PMID:27539251 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
fludioxonil results in increased expression of CYP1A1 mRNA; fludioxonil results in increased expression of CYP1A1 protein [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA |
CTD |
PMID:32194361 PMID:33575850 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
fludioxonil results in increased expression of CYP1A2 mRNA [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA |
CTD |
PMID:33575850 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions increases expression |
ISO |
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA; [propiconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA; [tebuconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA fludioxonil results in increased expression of CYP2B6 mRNA |
CTD |
PMID:33575850 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases expression |
ISO |
fludioxonil results in decreased expression of CYP2C19 protein |
CTD |
PMID:32194361 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO |
fludioxonil results in decreased activity of CYP3A4 protein [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25028461 PMID:33575850 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression |
ISO |
fludioxonil results in decreased expression of CYP7A1 protein |
CTD |
PMID:32194361 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
affects binding |
ISO |
fludioxonil binds to ERBB2 protein |
CTD |
PMID:32278787 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression increases activity |
ISO |
[fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; fludioxonil binds to and results in increased activity of ESR1 protein; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein] fludioxonil results in decreased expression of ESR1 mRNA fludioxonil results in increased activity of ESR1 protein |
CTD |
PMID:20143881 PMID:23052036 PMID:23436777 PMID:26812056 PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions increases expression decreases expression increases activity |
ISO |
[fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; fludioxonil binds to and results in increased activity of ESR2 protein; fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA] fludioxonil results in increased expression of ESR2 mRNA fludioxonil results in decreased expression of ESR2 mRNA fludioxonil results in increased activity of ESR2 protein |
CTD |
PMID:23052036 PMID:23436777 PMID:26812056 PMID:33049310 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
fludioxonil results in decreased expression of G6PC1 mRNA |
CTD |
PMID:32194361 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
ISO |
fludioxonil results in increased expression of GPX1 mRNA [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA |
CTD |
PMID:22880100 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of H2AX protein fludioxonil results in increased phosphorylation of H2AX protein |
CTD |
PMID:22389207 PMID:34503147 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
increases activity |
ISO |
fludioxonil results in increased activity of HSD11B2 protein |
CTD |
PMID:31927052 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Mir200a |
microRNA 200a |
increases expression |
ISO |
fludioxonil results in increased expression of MIR200A mRNA |
CTD |
PMID:23052036 |
|
NCBI chr 5:166,648,494...166,648,582
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|
G |
Mir21 |
microRNA 21 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] |
CTD |
PMID:23052036 |
|
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir22 |
microRNA 22 |
decreases expression |
ISO |
fludioxonil results in decreased expression of MIR22 mRNA |
CTD |
PMID:23052036 |
|
NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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G |
Mlxipl |
MLX interacting protein-like |
decreases expression multiple interactions |
ISO |
fludioxonil results in decreased expression of MLXIPL mRNA [difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA |
CTD |
PMID:33575850 |
|
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions decreases expression |
ISO |
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; fludioxonil binds to and results in increased activity of NR1I2 protein fludioxonil results in decreased expression of NR1I2 mRNA |
CTD |
PMID:25028461 PMID:33049310 PMID:33575850 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
decreases expression multiple interactions |
ISO |
fludioxonil results in decreased expression of NR1I3 mRNA [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA; [propiconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA; [tebuconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA |
CTD |
PMID:33575850 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nrf1 |
nuclear respiratory factor 1 |
increases expression |
ISO |
fludioxonil results in increased expression of NRF1 mRNA |
CTD |
PMID:23436777 |
|
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
fludioxonil results in increased expression of PARP1 protein |
CTD |
PMID:23052036 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
fludioxonil results in increased expression of PCNA protein |
CTD |
PMID:27539251 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdcd4 |
programmed cell death 4 |
decreases expression multiple interactions |
ISO |
fludioxonil results in decreased expression of PDCD4 mRNA; fludioxonil results in decreased expression of PDCD4 protein MIR21 mRNA mutant form inhibits the reaction [fludioxonil results in decreased expression of PDCD4 protein] |
CTD |
PMID:23052036 |
|
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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G |
Pgr |
progesterone receptor |
increases expression decreases expression multiple interactions |
ISO |
fludioxonil results in increased expression of PGR mRNA fludioxonil results in decreased expression of PGR mRNA Estradiol inhibits the reaction [fludioxonil results in increased expression of PGR mRNA] |
CTD |
PMID:23052036 PMID:23436777 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
fludioxonil binds to and results in increased activity of PPARG protein |
CTD |
PMID:33049310 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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|
G |
Pten |
phosphatase and tensin homolog |
decreases expression |
ISO |
fludioxonil results in decreased expression of PTEN mRNA |
CTD |
PMID:23052036 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[fludioxonil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 |
CTD |
PMID:26359731 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rarb |
retinoic acid receptor, beta |
decreases expression |
ISO |
fludioxonil results in decreased expression of RARB mRNA |
CTD |
PMID:23436777 |
|
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rxrb |
retinoid X receptor beta |
increases activity |
ISO |
fludioxonil results in increased activity of RXRB protein |
CTD |
PMID:20143881 |
|
NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein] |
CTD |
PMID:27539251 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
fludioxonil binds to and results in increased activity of THRA protein |
CTD |
PMID:33049310 |
|
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] affects the expression of TP53BP1 protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] affects the expression of TP53BP1 protein |
CTD |
PMID:34503147 |
|
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Vmp1 |
vacuole membrane protein 1 |
multiple interactions |
ISO |
[Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA |
CTD |
PMID:23052036 |
|
NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
|
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