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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antidiarrhoeal drug
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Accession:CHEBI:55323 term browser browse the term
Definition:Any drug found useful in the symptomatic treatment of diarrhoea.
Synonyms:related_synonym: antidiarrheal;   antidiarrheal agent;   antidiarrheal agents;   antidiarrheal drug;   antidiarrheal drugs;   antidiarrheals;   antidiarrhoeal;   antidiarrhoeal agent;   antidiarrhoeal agents;   antidiarrhoeal drugs;   antidiarrhoeals;   antiperistaltic;   antiperistaltic agent;   antiperistaltic agents;   antiperistaltic drug;   antiperistaltic drugs;   antiperistaltics


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diphenoxylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO Diphenoxylate affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
kaolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11 coagulation factor XI decreases activity ISO Kaolin results in decreased activity of F11 protein CTD PMID:6604052 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G F12 coagulation factor XII increases activity ISO Kaolin results in increased activity of F12 protein CTD PMID:6343536 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Loperamide results in decreased expression of ABCB11 mRNA CTD PMID:35926757 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
affects response to substance
increases transport
multiple interactions
decreases expression		 ISO Loperamide binds to ABCB1 protein
ABCB1A protein affects the susceptibility to Loperamide
ABCB1 protein results in increased transport of Loperamide
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
Loperamide results in decreased expression of ABCB1 mRNA		 CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Loperamide results in decreased expression of ABCC2 mRNA CTD PMID:35926757 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Loperamide results in decreased expression of ABCG5 mRNA CTD PMID:35926757 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions		 ISO Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]		 CTD PMID:37375548 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA		 CTD PMID:34719826 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]		 CTD PMID:34719826 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions		 ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate		 CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Loperamide results in increased expression of CH25H mRNA CTD PMID:35926757 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Loperamide results in increased expression of CYP7A1 mRNA CTD PMID:35926757 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Loperamide results in increased expression of FABP6 mRNA CTD PMID:35926757 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Loperamide results in increased expression of FDPS mRNA CTD PMID:35926757 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
decreases expression		 ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA] CTD PMID:37375548 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Loperamide results in increased expression of IDI1 mRNA CTD PMID:35926757 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Lss lanosterol synthase increases expression ISO Loperamide results in increased expression of LSS mRNA CTD PMID:35926757 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions		 ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]		 CTD PMID:34719826 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression		 ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA		 CTD PMID:34719826 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mvk mevalonate kinase increases expression ISO Loperamide results in increased expression of MVK mRNA CTD PMID:35926757 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Mylk myosin light chain kinase decreases expression
multiple interactions		 ISO Loperamide results in decreased expression of MYLK mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]		 CTD PMID:37375548 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression		 ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein] CTD PMID:37375548 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Ryr3 ryanodine receptor 3 decreases expression
multiple interactions		 ISO Loperamide results in decreased expression of RYR3 mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]		 CTD PMID:37375548 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Loperamide results in increased expression of SLC51A mRNA CTD PMID:35926757 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Loperamide results in increased expression of SQLE mRNA CTD PMID:35926757 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 multiple interactions
decreases expression		 ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein] CTD PMID:37375548 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190 		JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
decreases activity		 ISO [tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to tectochrysin		 CTD PMID:37259354 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            gastrointestinal drug 377
              antidiarrhoeal drug 46
                bicozamycin 0
                difenoxin + 1
                difenoxin hydrochloride 0
                diphenoxylate + 1
                diphenoxylate hydrochloride 0
                isovanillin 0
                kaolin 2
                loperamide 42
                loperamide hydrochloride 0
                morphine hydrochloride trihydrate 0
                pectin + 0
                tectochrysin 2
paths to the root