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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:loperamide
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Accession:CHEBI:6532 term browser browse the term
Definition:A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Synonyms:exact_synonym: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
 related_synonym: Formula=C29H33ClN2O2;   InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3;   InChIKey=RDOIQAHITMMDAJ-UHFFFAOYSA-N;   SMILES=CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1;   loperamida;   loperamidum
 xref: Beilstein:1558273;   CAS:53179-11-6;   DrugBank:DB00836;   Drug_Central:1599;   HMDB:HMDB0004999;   KEGG:C07080;   KEGG:D08144;   LINCS:LSM-3365
 xref_mesh: MESH:D008139
 xref: PMID:15900907;   PMID:19034106;   PMID:24398461;   Patent:FR2100711;   Patent:US3714159;   Reaxys:1558273;   Wikipedia:Loperamide
 cyclic_relationship: is_conjugate_base_of CHEBI:86969



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loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Loperamide results in decreased expression of ABCB11 mRNA CTD PMID:35926757 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
multiple interactions
increases transport
affects response to substance
ISO Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide
CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Loperamide results in decreased expression of ABCC2 mRNA CTD PMID:35926757 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Loperamide results in decreased expression of ABCG5 mRNA CTD PMID:35926757 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA
CTD PMID:34719826 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:34719826 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions
ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate
CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Loperamide results in increased expression of CH25H mRNA CTD PMID:35926757 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Loperamide results in increased expression of CYP7A1 mRNA CTD PMID:35926757 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Loperamide results in increased expression of FABP6 mRNA CTD PMID:35926757 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Loperamide results in increased expression of FDPS mRNA CTD PMID:35926757 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Loperamide results in increased expression of IDI1 mRNA CTD PMID:35926757 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lss lanosterol synthase increases expression ISO Loperamide results in increased expression of LSS mRNA CTD PMID:35926757 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]
CTD PMID:34719826 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA
CTD PMID:34719826 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mvk mevalonate kinase increases expression ISO Loperamide results in increased expression of MVK mRNA CTD PMID:35926757 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO Loperamide results in increased expression of SLC51A mRNA CTD PMID:35926757 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Sqle squalene epoxidase increases expression ISO Loperamide results in increased expression of SQLE mRNA CTD PMID:35926757 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        antimicrobial agent 17945
          antiviral agent 10808
            anticoronaviral agent 9346
              loperamide 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        carboacyl group 17687
                                          univalent carboacyl group 17687
                                            carbamoyl group 17531
                                              carboxamide 17531
                                                monocarboxylic acid amide 15585
                                                  loperamide 36
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