Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:loperamide
go back to main search page
Accession:CHEBI:6532 term browser browse the term
Definition:A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Synonyms:exact_synonym: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
 related_synonym: Formula=C29H33ClN2O2;   InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3;   InChIKey=RDOIQAHITMMDAJ-UHFFFAOYSA-N;   SMILES=CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1;   loperamida;   loperamidum
 xref: Beilstein:1558273 "Beilstein";   CAS:53179-11-6 "ChemIDplus";   CAS:53179-11-6 "KEGG COMPOUND";   DrugBank:DB00836;   Drug_Central:1599 "DrugCentral";   HMDB:HMDB0004999;   KEGG:C07080;   KEGG:D08144;   LINCS:LSM-3365
 xref_mesh: MESH:D008139
 xref: PMID:15900907 "Europe PMC";   PMID:19034106 "Europe PMC";   PMID:24398461 "Europe PMC";   Patent:FR2100711;   Patent:US3714159;   Reaxys:1558273 "Reaxys";   Wikipedia:Loperamide
 cyclic_relationship: is_conjugate_base_of CHEBI:86969


show annotations for term's descendants       view all columns           Sort by:
 
loperamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B JBrowse link 4 22,225,123 22,307,577 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Ckb creatine kinase B JBrowse link 6 136,142,956 136,145,838 RGD:6480464
G Ckm creatine kinase, M-type JBrowse link 1 80,321,507 80,331,841 RGD:6480464
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:6480464
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tnni3 troponin I3, cardiac type JBrowse link 1 72,882,806 72,886,490 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        pharmacological role 18680
          agonist 18011
            opioid receptor agonist 639
              mu-opioid receptor agonist 632
                loperamide 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  loperamide 18
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.