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heptachlor - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:heptachlor
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Accession:CHEBI:34785 term browser browse the term
Definition:A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Synonyms:exact_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
 related_synonym: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene;   1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene;   3-chlorochlordene;   Formula=C10H5Cl7;   Heptachlorane;   Heptamul;   InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H;   InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N;   SMILES=ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
 xref: CAS:76-44-8;   KEGG:C14185
 xref_mesh: MESH:D006533
 xref: PMID:24177859;   PMID:24577234;   PPDB:378;   Reaxys:2058523;   Wikipedia:Heptachlor

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heptachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Heptachlor results in increased expression of ABCB1 mRNA CTD PMID:24464585 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) increases expression ISO Heptachlor results in increased expression of ABCC1 mRNA CTD PMID:23153324 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases activity
increases expression 		EXP Heptachlor results in decreased activity of ABCC2 protein
Heptachlor results in increased expression of ABCC2 mRNA 		CTD PMID:24464585 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 decreases expression ISO Heptachlor results in decreased expression of ABCC6 mRNA CTD PMID:23153324 NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) decreases activity EXP Heptachlor results in decreased activity of ABCG2 protein CTD PMID:24464585 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle increases expression EXP Heptachlor results in increased expression of ACTA2 mRNA; Heptachlor results in increased expression of ACTA2 protein CTD PMID:30719927 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ALB albumin decreases expression EXP Heptachlor results in decreased expression of ALB mRNA CTD PMID:22902829 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALCAM activated leukocyte cell adhesion molecule decreases expression ISO Heptachlor results in decreased expression of ALCAM mRNA CTD PMID:23153324 NCBI chr 3:105,366,909...105,576,900
Ensembl chr 3:105,366,909...105,576,900 		JBrowse link
G AQP11 aquaporin 11 decreases expression ISO Heptachlor results in decreased expression of AQP11 mRNA CTD PMID:23153324 NCBI chr11:77,589,953...77,610,356
Ensembl chr11:77,589,391...77,610,356 		JBrowse link
G AQP9 aquaporin 9 decreases expression ISO Heptachlor results in decreased expression of AQP9 mRNA CTD PMID:23153324 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911 		JBrowse link
G AR androgen receptor affects binding
multiple interactions 		ISO
EXP 		Heptachlor binds to AR protein
Heptachlor inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] 		CTD PMID:14565775 PMID:26022396 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATP6V0E2 ATPase H+ transporting V0 subunit e2 decreases expression ISO Heptachlor results in decreased expression of ATP6V0E2 mRNA CTD PMID:23153324 NCBI chr 7:149,872,964...149,880,713
Ensembl chr 7:149,872,968...149,891,204 		JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions EXP [Insecticides results in increased abundance of Heptachlor] which affects the methylation of ATP8B1 gene CTD PMID:34516295 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315 		JBrowse link
G AURKB aurora kinase B increases expression ISO Heptachlor results in increased expression of AURKB mRNA CTD PMID:23153324 NCBI chr17:8,204,731...8,210,575
Ensembl chr17:8,204,733...8,210,600 		JBrowse link
G BCAT1 branched chain amino acid transaminase 1 increases expression ISO Heptachlor results in increased expression of BCAT1 mRNA CTD PMID:23153324 NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression ISO Heptachlor results in increased expression of BCL2 protein CTD PMID:14678745 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G C1QA complement C1q A chain decreases expression ISO Heptachlor results in decreased expression of C1QA mRNA CTD PMID:23153324 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093 		JBrowse link
G CCNB1 cyclin B1 increases expression ISO Heptachlor results in increased expression of CCNB1 mRNA CTD PMID:23153324 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNB2 cyclin B2 increases expression ISO Heptachlor results in increased expression of CCNB2 mRNA CTD PMID:23153324 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045 		JBrowse link
G CDH1 cadherin 1 decreases expression
multiple interactions 		EXP Heptachlor results in decreased expression of CDH1 mRNA; Heptachlor results in decreased expression of CDH1 protein
Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein] 		CTD PMID:22902829 PMID:30719927 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 increases expression ISO Heptachlor results in increased expression of CDKN3 mRNA CTD PMID:23153324 NCBI chr14:54,397,007...54,420,218
Ensembl chr14:54,396,849...54,420,218 		JBrowse link
G CENPE centromere protein E increases expression ISO Heptachlor results in increased expression of CENPE mRNA CTD PMID:23153324 NCBI chr 4:103,105,811...103,198,343
Ensembl chr 4:103,105,349...103,198,445 		JBrowse link
G CFD complement factor D decreases expression ISO Heptachlor results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884 		JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit decreases expression ISO Heptachlor results in decreased expression of CHRNA1 mRNA CTD PMID:23153324 NCBI chr 2:174,747,592...174,764,472
Ensembl chr 2:174,747,592...174,787,935 		JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression EXP Heptachlor results in increased expression of COL1A1 mRNA CTD PMID:22902829 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COX5B cytochrome c oxidase subunit 5B decreases expression ISO Heptachlor results in decreased expression of COX5B mRNA CTD PMID:23153324 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions
increases expression 		EXP Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]
Heptachlor results in increased expression of CTNNB1 protein 		CTD PMID:22902829 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein] CTD PMID:14678745 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity EXP Heptachlor results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G E2F8 E2F transcription factor 8 increases expression ISO Heptachlor results in increased expression of E2F8 mRNA CTD PMID:23153324 NCBI chr11:19,224,063...19,241,655
Ensembl chr11:19,224,063...19,241,620 		JBrowse link
G ECT2 epithelial cell transforming 2 increases expression ISO Heptachlor results in increased expression of ECT2 mRNA CTD PMID:23153324 NCBI chr 3:172,750,726...172,829,265
Ensembl chr 3:172,750,682...172,821,474 		JBrowse link
G ELOVL7 ELOVL fatty acid elongase 7 increases expression ISO Heptachlor results in increased expression of ELOVL7 mRNA CTD PMID:23153324 NCBI chr 5:60,751,791...60,844,269
Ensembl chr 5:60,751,791...60,844,274 		JBrowse link
G ESR1 estrogen receptor 1 increases activity
multiple interactions
increases expression 		EXP
ISO 		Heptachlor results in increased activity of ESR1 protein
Heptachlor inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
Heptachlor results in increased expression of ESR1 		CTD PMID:26022396 PMID:26139245 PMID:27240701 PMID:28531659 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 increases activity EXP Heptachlor results in increased activity of ESR2 protein CTD PMID:15064155 PMID:26139245 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G EXOC5 exocyst complex component 5 multiple interactions EXP [Insecticides results in increased abundance of Heptachlor] which affects the methylation of EXOC5 gene CTD PMID:34516295 NCBI chr14:57,200,507...57,268,905
Ensembl chr14:57,200,507...57,268,905 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression ISO Heptachlor results in increased expression of EZH2 mRNA CTD PMID:23153324 NCBI chr 7:148,807,383...148,884,291
Ensembl chr 7:148,807,257...148,884,321 		JBrowse link
G FAAH fatty acid amide hydrolase decreases expression ISO Heptachlor results in decreased expression of FAAH mRNA CTD PMID:23153324 NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848 		JBrowse link
G FMNL2 formin like 2 increases expression ISO Heptachlor results in increased expression of FMNL2 mRNA CTD PMID:23153324 NCBI chr 2:152,335,174...152,649,826
Ensembl chr 2:152,335,174...152,649,826 		JBrowse link
G FN1 fibronectin 1 increases expression
decreases expression 		EXP
ISO 		Heptachlor results in increased expression of FN1 protein
Heptachlor results in decreased expression of FN1 mRNA 		CTD PMID:22902829 PMID:23153324 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G GAP43 growth associated protein 43 multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA] CTD PMID:28385489 NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490 		JBrowse link
G GJA1 gap junction protein alpha 1 decreases expression EXP Heptachlor results in decreased expression of GJA1 protein CTD PMID:8738476 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 decreases expression ISO Heptachlor results in decreased expression of HIPK2 mRNA CTD PMID:23153324 NCBI chr 7:139,561,570...139,777,998
Ensembl chr 7:139,561,570...139,777,998 		JBrowse link
G HK2 hexokinase 2 increases expression ISO Heptachlor results in increased expression of HK2 mRNA CTD PMID:23153324 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G HRAS HRas proto-oncogene, GTPase decreases expression EXP Heptachlor results in decreased expression of HRAS mRNA CTD PMID:1771636 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO Heptachlor results in decreased expression of IGF1 mRNA CTD PMID:23153324 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL13RA1 interleukin 13 receptor subunit alpha 1 decreases expression ISO Heptachlor results in decreased expression of IL13RA1 mRNA CTD PMID:23153324 NCBI chr  X:118,727,606...118,805,228
Ensembl chr  X:118,727,133...118,794,535 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough affects secretion ISO Heptachlor affects the secretion of INS1 protein CTD PMID:31923579 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G ITGA5 integrin subunit alpha 5 increases expression EXP Heptachlor results in increased expression of ITGA5 mRNA CTD PMID:22902829 NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Heptachlor results in increased phosphorylation of JUN protein CTD PMID:15888667 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KIF18B kinesin family member 18B increases expression ISO Heptachlor results in increased expression of KIF18B mRNA CTD PMID:23153324 NCBI chr17:44,924,711...44,947,773
Ensembl chr17:44,924,709...44,947,773 		JBrowse link
G LINC00881 long intergenic non-protein coding RNA 881 multiple interactions EXP [Insecticides results in increased abundance of Heptachlor] which affects the methylation of LINC00881 gene CTD PMID:34516295 NCBI chr 3:157,089,881...157,101,135
Ensembl chr 3:157,089,634...157,381,265 		JBrowse link
G LRRC1 leucine rich repeat containing 1 increases expression ISO Heptachlor results in increased expression of LRRC1 mRNA CTD PMID:23153324 NCBI chr 6:53,795,005...53,924,125
Ensembl chr 6:53,794,497...53,924,125 		JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 increases expression ISO Heptachlor results in increased expression of MAD2L1 mRNA CTD PMID:23153324 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858 		JBrowse link
G MAOB monoamine oxidase B decreases expression ISO Heptachlor results in decreased expression of MAOB mRNA CTD PMID:23153324 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions EXP Heptachlor promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions
decreases expression 		EXP Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein
Heptachlor results in decreased expression of MAP2K1 protein 		CTD PMID:9704902 PMID:15888667 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 multiple interactions EXP Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 decreases expression EXP Heptachlor results in decreased expression of MAP3K1 protein CTD PMID:9704902 NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
multiple interactions 		EXP
ISO 		Heptachlor results in decreased expression of MAPK1 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein] 		CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases expression
multiple interactions 		EXP
ISO 		Heptachlor results in decreased expression of MAPK3 protein
calphostin C inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; Heptachlor results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein] 		CTD PMID:9704902 PMID:14678745 PMID:15888667 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMD monocyte to macrophage differentiation associated increases expression ISO Heptachlor results in increased expression of MMD mRNA CTD PMID:23153324 NCBI chr17:55,392,622...55,421,835
Ensembl chr17:55,392,622...55,421,924 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression ISO Heptachlor results in increased expression of MMP9 mRNA CTD PMID:23153324 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NANOG Nanog homeobox multiple interactions EXP Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA] CTD PMID:32949729 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146 		JBrowse link
G NGF nerve growth factor multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of GAP43 mRNA]; Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NNT nicotinamide nucleotide transhydrogenase decreases expression ISO Heptachlor results in decreased expression of NNT mRNA CTD PMID:23153324 NCBI chr 5:43,602,675...43,707,396
Ensembl chr 5:43,602,692...43,707,405 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO
EXP 		Heptachlor binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Heptachlor results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G NT5DC2 5'-nucleotidase domain containing 2 increases expression ISO Heptachlor results in increased expression of NT5DC2 mRNA CTD PMID:23153324 NCBI chr 3:52,524,387...52,535,027
Ensembl chr 3:52,524,385...52,535,054 		JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 decreases expression ISO Heptachlor results in decreased expression of ORAI1 mRNA CTD PMID:23153324 NCBI chr12:121,626,530...121,643,109
Ensembl chr12:121,626,509...121,643,218 		JBrowse link
G P2RX4 purinergic receptor P2X 4 decreases expression ISO Heptachlor results in decreased expression of P2RX4 mRNA CTD PMID:23153324 NCBI chr12:121,210,129...121,234,106
Ensembl chr12:121,210,065...121,234,106 		JBrowse link
G PAX6 paired box 6 multiple interactions EXP Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 decreases expression ISO Heptachlor results in decreased expression of PDK4 mRNA CTD PMID:23153324 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
G PGR progesterone receptor increases expression
multiple interactions 		ISO
EXP 		Heptachlor results in increased expression of PGR
Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] 		CTD PMID:26022396 PMID:27240701 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PI4KA phosphatidylinositol 4-kinase alpha decreases activity
increases activity 		EXP Heptachlor results in decreased activity of PI4KA protein
Heptachlor results in increased activity of PI4KA protein 		CTD PMID:14994277 NCBI chr22:20,707,691...20,858,811
Ensembl chr22:20,707,691...20,859,417 		JBrowse link
G POU5F1 POU class 5 homeobox 1 multiple interactions EXP Heptachlor inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731 		JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Heptachlor affects the localization of and results in increased activity of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein] CTD PMID:14678745 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PRKCD protein kinase C delta multiple interactions ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Heptachlor affects the localization of and results in increased activity of PRKCD protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] CTD PMID:14678745 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 decreases expression ISO Heptachlor results in decreased expression of PSMB9 mRNA CTD PMID:23153324 NCBI chr 6:32,854,192...32,859,851
Ensembl chr 6:32,844,136...32,860,734 		JBrowse link
G PTGER3 prostaglandin E receptor 3 decreases expression ISO Heptachlor results in decreased expression of PTGER3 mRNA CTD PMID:23153324 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
G PTTG1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Heptachlor results in increased expression of PTTG1 mRNA CTD PMID:23153324 NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP Heptachlor results in increased phosphorylation of and results in increased activity of RAF1 protein CTD PMID:15888667 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP Heptachlor results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RFC4 replication factor C subunit 4 increases expression ISO Heptachlor results in increased expression of RFC4 mRNA CTD PMID:23153324 NCBI chr 3:186,789,900...186,806,482
Ensembl chr 3:186,789,880...186,807,058 		JBrowse link
G SGMS1 sphingomyelin synthase 1 decreases expression ISO Heptachlor results in decreased expression of SGMS1 mRNA CTD PMID:23153324 NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,163 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression EXP
ISO 		Heptachlor results in decreased expression of SLC10A1 mRNA CTD PMID:23153324 PMID:24464585 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 decreases expression ISO Heptachlor results in decreased expression of SLC16A1 mRNA CTD PMID:23153324 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593 		JBrowse link
G SLC16A4 solute carrier family 16 member 4 decreases expression ISO Heptachlor results in decreased expression of SLC16A4 mRNA CTD PMID:23153324 NCBI chr 1:110,362,857...110,391,026
Ensembl chr 1:110,362,851...110,391,082 		JBrowse link
G SLC16A7 solute carrier family 16 member 7 decreases expression ISO Heptachlor results in decreased expression of SLC16A7 mRNA CTD PMID:23153324 NCBI chr12:59,596,029...59,789,841
Ensembl chr12:59,596,029...59,789,855 		JBrowse link
G SLC17A2 solute carrier family 17 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC17A2 mRNA CTD PMID:23153324 NCBI chr 6:25,912,754...25,930,691
Ensembl chr 6:25,912,754...25,930,691 		JBrowse link
G SLC17A3 solute carrier family 17 member 3 decreases expression ISO Heptachlor results in decreased expression of SLC17A3 mRNA CTD PMID:23153324 NCBI chr 6:25,844,856...25,874,243
Ensembl chr 6:25,833,066...25,882,286 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 increases expression ISO Heptachlor results in increased expression of SLC18A2 mRNA; Heptachlor results in increased expression of SLC18A2 protein CTD PMID:10499361 PMID:16112329 PMID:18577399 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
G SLC19A2 solute carrier family 19 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC19A2 mRNA CTD PMID:23153324 NCBI chr 1:169,463,909...169,485,970
Ensembl chr 1:169,463,909...169,485,944 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 decreases activity EXP Heptachlor results in decreased activity of SLC22A1 protein CTD PMID:24464585 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC25A1 solute carrier family 25 member 1 decreases expression ISO Heptachlor results in decreased expression of SLC25A1 mRNA CTD PMID:23153324 NCBI chr22:19,175,581...19,178,736
Ensembl chr22:19,175,581...19,178,739 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) decreases expression ISO Heptachlor results in decreased expression of SLC29A1 mRNA CTD PMID:23153324 NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC2A2 mRNA CTD PMID:23153324 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression ISO Heptachlor results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC30A5 solute carrier family 30 member 5 decreases expression ISO Heptachlor results in decreased expression of SLC30A5 mRNA CTD PMID:23153324 NCBI chr 5:69,094,014...69,131,069
Ensembl chr 5:69,093,991...69,131,069 		JBrowse link
G SLC31A2 solute carrier family 31 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC31A2 mRNA CTD PMID:23153324 NCBI chr 9:113,151,007...113,164,140
Ensembl chr 9:113,150,976...113,164,140 		JBrowse link
G SLC34A2 solute carrier family 34 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC34A2 mRNA CTD PMID:23153324 NCBI chr 4:25,655,851...25,678,748
Ensembl chr 4:25,648,011...25,678,748 		JBrowse link
G SLC37A4 solute carrier family 37 member 4 decreases expression ISO Heptachlor results in decreased expression of SLC37A4 mRNA CTD PMID:23153324 NCBI chr11:119,024,112...119,030,877
Ensembl chr11:119,023,751...119,030,906 		JBrowse link
G SLC38A1 solute carrier family 38 member 1 increases expression ISO Heptachlor results in increased expression of SLC38A1 mRNA CTD PMID:23153324 NCBI chr12:46,183,063...46,269,043
Ensembl chr12:46,183,063...46,270,017 		JBrowse link
G SLC5A6 solute carrier family 5 member 6 decreases expression ISO Heptachlor results in decreased expression of SLC5A6 mRNA CTD PMID:23153324 NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions
increases expression 		ISO Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Heptachlor results in increased expression of SLC6A3 mRNA; Heptachlor results in increased expression of SLC6A3 protein 		CTD PMID:10499361 PMID:11294980 PMID:11719704 PMID:12428726 PMID:16112329 More... NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SLC7A2 solute carrier family 7 member 2 decreases expression ISO Heptachlor results in decreased expression of SLC7A2 mRNA CTD PMID:23153324 NCBI chr 8:17,494,069...17,570,566
Ensembl chr 8:17,497,088...17,570,573 		JBrowse link
G SLC7A6 solute carrier family 7 member 6 decreases expression ISO Heptachlor results in decreased expression of SLC7A6 mRNA CTD PMID:23153324 NCBI chr16:68,264,526...68,301,819
Ensembl chr16:68,264,516...68,301,823 		JBrowse link
G SMAD2 SMAD family member 2 increases expression EXP Heptachlor results in increased expression of SMAD2 mRNA; Heptachlor results in increased expression of SMAD2 protein modified form CTD PMID:30719927 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 increases expression EXP Heptachlor results in increased expression of SMAD3 mRNA; Heptachlor results in increased expression of SMAD3 protein modified form CTD PMID:30719927 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO Heptachlor results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 decreases expression ISO Heptachlor results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression 		ISO
EXP 		Heptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein]
Heptachlor results in increased expression of TGFB1 mRNA 		CTD PMID:14678745 PMID:30719927 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGM2 transglutaminase 2 decreases expression ISO Heptachlor results in decreased expression of TGM2 mRNA CTD PMID:23153324 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
G TH tyrosine hydroxylase increases expression ISO Heptachlor results in increased expression of TH protein CTD PMID:16112329 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TP53 tumor protein p53 decreases expression EXP Heptachlor results in decreased expression of TP53 protein CTD PMID:9544696 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 increases expression ISO Heptachlor results in increased expression of TRIP13 mRNA CTD PMID:23153324 NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357 		JBrowse link
G TSPO translocator protein increases expression ISO Heptachlor results in increased expression of TSPO CTD PMID:14699885 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242 		JBrowse link
G TUBB3 tubulin beta 3 class III multiple interactions ISO Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA] CTD PMID:28385489 NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761 		JBrowse link
G UQCRH ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Heptachlor results in decreased expression of UQCRH mRNA CTD PMID:23153324 NCBI chr 1:46,303,698...46,316,776
Ensembl chr 1:46,303,698...46,316,776 		JBrowse link
G VIM vimentin increases expression EXP Heptachlor results in increased expression of VIM mRNA; Heptachlor results in increased expression of VIM protein CTD PMID:22902829 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G WFDC2 WAP four-disulfide core domain 2 decreases expression ISO Heptachlor results in decreased expression of WFDC2 mRNA CTD PMID:23153324 NCBI chr20:45,469,753...45,481,532
Ensembl chr20:45,469,753...45,481,532 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26798
    role 26626
      application 25640
        agrochemical 18580
          heptachlor 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 26798
    subatomic particle 26774
      composite particle 26774
        hadron 26774
          baryon 26774
            nucleon 26774
              atomic nucleus 26774
                atom 26774
                  main group element atom 26525
                    main group molecular entity 26525
                      s-block molecular entity 25560
                        hydrogen molecular entity 24987
                          hydrides 23128
                            organic hydride 22052
                              organic fundamental parent 22052
                                hydrocarbon 21494
                                  cyclic hydrocarbon 20061
                                    arene 20042
                                      polycyclic arene 19729
                                        ortho-fused polycyclic arene 10383
                                          ortho-fused bicyclic arene 2420
                                            1H-indene 123
                                              heptachlor 121
paths to the root